Mouse Models for Studying HCV Vaccines and Therapeutic Antibodies.

TitleMouse Models for Studying HCV Vaccines and Therapeutic Antibodies.
Publication TypeJournal Article
Year of Publication2019
AuthorsGaska, JM, Ding, Q, Ploss, A
JournalMethods Mol Biol
Volume1911
Pagination481-503
Date Published2019
ISSN1940-6029
KeywordsAnimals, Antibodies, Neutralizing, Disease Models, Animal, Hepacivirus, Hepatitis C, Humans, Immunogenicity, Vaccine, Liver, Liver Transplantation, Mice, Mice, Transgenic, Neutralization Tests, Transplantation Chimera, Treatment Outcome, Viral Envelope Proteins, Viral Hepatitis Vaccines
Abstract

<p>In spite of the immense progress in hepatitis C virus (HCV) research, efforts to prevent infection, such as generating a vaccine, have not yet been successful. The high price tag associated with current treatment options for chronic infection and the spike in new infections concurrent with growing opioid abuse are strong motivators for developing effective immunization and understanding neutralizing antibodies' role in preventing infection. Humanized mice-both human liver chimeras as well as genetically humanized models-are important platforms for testing both possible vaccine candidates as well as antibody-based therapies. This chapter details the variety of ways humanized mouse technology can be employed in pursuit of learning how HCV infection can be prevented.</p>

DOI10.1007/978-1-4939-8976-8_33
Alternate JournalMethods Mol. Biol.
PubMed ID30593647
PubMed Central IDPMC6699619
Grant ListR01 AI079031 / AI / NIAID NIH HHS / United States
R01 AI107301 / AI / NIAID NIH HHS / United States
R21 AI117213 / AI / NIAID NIH HHS / United States
T32 GM007388 / GM / NIGMS NIH HHS / United States