Title | Mouse Models for Studying HCV Vaccines and Therapeutic Antibodies. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Gaska, JM, Ding, Q, Ploss, A |
Journal | Methods Mol Biol |
Volume | 1911 |
Pagination | 481-503 |
Date Published | 2019 |
ISSN | 1940-6029 |
Keywords | Animals, Antibodies, Neutralizing, Disease Models, Animal, Hepacivirus, Hepatitis C, Humans, Immunogenicity, Vaccine, Liver, Liver Transplantation, Mice, Mice, Transgenic, Neutralization Tests, Transplantation Chimera, Treatment Outcome, Viral Envelope Proteins, Viral Hepatitis Vaccines |
Abstract | <p>In spite of the immense progress in hepatitis C virus (HCV) research, efforts to prevent infection, such as generating a vaccine, have not yet been successful. The high price tag associated with current treatment options for chronic infection and the spike in new infections concurrent with growing opioid abuse are strong motivators for developing effective immunization and understanding neutralizing antibodies' role in preventing infection. Humanized mice-both human liver chimeras as well as genetically humanized models-are important platforms for testing both possible vaccine candidates as well as antibody-based therapies. This chapter details the variety of ways humanized mouse technology can be employed in pursuit of learning how HCV infection can be prevented.</p> |
DOI | 10.1007/978-1-4939-8976-8_33 |
Alternate Journal | Methods Mol Biol |
PubMed ID | 30593647 |
PubMed Central ID | PMC6699619 |
Grant List | R01 AI079031 / AI / NIAID NIH HHS / United States R01 AI107301 / AI / NIAID NIH HHS / United States R21 AI117213 / AI / NIAID NIH HHS / United States T32 GM007388 / GM / NIGMS NIH HHS / United States |