| Title | Mouse genomic screen reveals novel host regulator of metastasis. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Celià-Terrassa, T, Kang, Y |
| Journal | Genome Biol |
| Volume | 18 |
| Issue | 1 |
| Pagination | 31 |
| Date Published | 2017 02 16 |
| ISSN | 1474-760X |
| Keywords | Animals, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, Genome, Genomics, Mice, Models, Biological, Neoplasm Metastasis, Neoplasms |
| Abstract | <p>Tumor cells have to overcome challenges in the host tissue microenvironment to metastasize successfully to distant organs. In a recent Nature study, a genome-wide functional screen demonstrated that deficiency of the sphingosine-1-phoshate (S1P) transporter gene Spns2 in endothelium increased immune-mediated cell killing by T cells and natural killer (NK) cells, thereby suppressing metastatic colonization.</p> |
| DOI | 10.1186/s13059-017-1170-x |
| Alternate Journal | Genome Biol |
| PubMed ID | 28209174 |
| PubMed Central ID | PMC5314612 |
| Grant List | R01 CA141062 / CA / NCI NIH HHS / United States |
