Mouse genomic screen reveals novel host regulator of metastasis.

TitleMouse genomic screen reveals novel host regulator of metastasis.
Publication TypeJournal Article
Year of Publication2017
AuthorsCelià-Terrassa, T, Kang, Y
JournalGenome Biol
Volume18
Issue1
Pagination31
Date Published2017 02 16
ISSN1474-760X
KeywordsAnimals, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, Genome, Genomics, Mice, Models, Biological, Neoplasm Metastasis, Neoplasms
Abstract

<p>Tumor cells have to overcome challenges in the host tissue microenvironment to metastasize successfully to distant organs. In a recent Nature study, a genome-wide functional screen demonstrated that deficiency of the sphingosine-1-phoshate (S1P) transporter gene Spns2 in endothelium increased immune-mediated cell killing by T cells and natural killer (NK) cells, thereby suppressing metastatic colonization.</p>

DOI10.1186/s13059-017-1170-x
Alternate JournalGenome Biol.
PubMed ID28209174
PubMed Central IDPMC5314612
Grant ListR01 CA141062 / CA / NCI NIH HHS / United States