Molecular architecture of the complete COG tethering complex.

Publication Year
2016

Type

Journal Article
Abstract

The conserved oligomeric Golgi (COG) complex orchestrates vesicular trafficking to and within the Golgi apparatus. Here, we use negative-stain electron microscopy to elucidate the architecture of the hetero-octameric COG complex from Saccharomyces cerevisiae. Intact COG has an intricate shape, with four (or possibly five) flexible legs, that differs strikingly from that of the exocyst complex and appears to be well suited for vesicle capture and fusion.

Journal
Nat Struct Mol Biol
Volume
23
Issue
8
Pages
758-60
Date Published
2016 Aug
ISSN Number
1545-9985
Alternate Journal
Nat Struct Mol Biol
PMCID
PMC4972656
PMID
27428773