Modeling Syndromic Congenital Heart Defects in Zebrafish.

TitleModeling Syndromic Congenital Heart Defects in Zebrafish.
Publication TypeJournal Article
Year of Publication2017
AuthorsGrant, MG, Patterson, VL, Grimes, DT, Burdine, RD
JournalCurr Top Dev Biol
Date Published2017
KeywordsAnimals, Disease Models, Animal, Heart, Heart Defects, Congenital, Humans, Models, Biological, Syndrome, Zebrafish

<p>Cardiac development is a dynamic process regulated by spatial and temporal cues that are integrated to effect molecular, cellular, and tissue-level events that form the adult heart. Disruption of these highly orchestrated events can be devastating for cardiac form and function. Aberrations in heart development result in congenital heart defects (CHDs), which affect 1 in 100 infants in the United States each year. Zebrafish have proven informative as a model organism to understand both heart development and the mechanisms associated with CHDs due to the similarities in heart morphogenesis among vertebrates, as well as their genetic tractability and amenability to live imaging. In this review, we discuss the mechanisms of zebrafish heart development and the utility of zebrafish for understanding syndromic CHDs, those cardiac abnormalities that occur in the context of multisystem disorders. We conclude with avenues of zebrafish research that will potentially inform future therapeutic approaches for the treatment of CHDs.</p>

Alternate JournalCurr Top Dev Biol
PubMed ID28335857
Grant ListR01 GM086537 / GM / NIGMS NIH HHS / United States
R01 HD048584 / HD / NICHD NIH HHS / United States