Modeling branching morphogenesis using materials with programmable mechanical instabilities.

TitleModeling branching morphogenesis using materials with programmable mechanical instabilities.
Publication TypeJournal Article
Year of Publication2018
AuthorsKourouklis, AP, Nelson, CM
JournalCurr Opin Biomed Eng
Volume6
Pagination66-73
Date Published2018 Jun
ISSN2468-4511
Abstract

The architectural features of branching morphogenesis demonstrate exquisite reproducibility among various organs and species despite the unique functionality and biochemical differences of their microenvironment. The regulatory networks that drive branching morphogenesis employ cell-generated and passive mechanical forces, which integrate extracellular signals from the microenvironment into morphogenetic movements. Cell-generated forces function locally to remodel the extracellular matrix (ECM) and control interactions among neighboring cells. Passive mechanical forces are the product of mechanical instabilities that trigger out-of-plane buckling and clefting deformations of adjacent tissues. Many of the molecular and physical signals that underlie buckling and clefting morphogenesis remain unclear and require new experimental strategies to be uncovered. Here, we highlight soft material systems that have been engineered to display programmable buckles and creases. Using synthetic materials to model physicochemical and spatiotemporal features of buckling and clefting morphogenesis might facilitate our understanding of the physical mechanisms that drive branching morphogenesis across different organs and species.

DOI10.1016/j.cobme.2018.03.007
Alternate JournalCurr Opin Biomed Eng
PubMed ID30345410
PubMed Central IDPMC6193561
Grant ListU01 CA214292 / CA / NCI NIH HHS / United States
R21 HL110335 / HL / NHLBI NIH HHS / United States
R01 CA187692 / CA / NCI NIH HHS / United States
R21 HL118532 / HL / NHLBI NIH HHS / United States
R01 HL120142 / HL / NHLBI NIH HHS / United States