Microbial metabolite as icebreaker for immunotherapy.

TitleMicrobial metabolite as icebreaker for immunotherapy.
Publication TypeJournal Article
Year of Publication2022
AuthorsTang, Y, Kang, Y
JournalCell Metab
Volume34
Issue4
Pagination506-507
Date Published2022/04/05
ISSN1932-7420
KeywordsHumans, Immunity, Cellular, Immunotherapy, Triple Negative Breast Neoplasms
Abstract

Immunotherapy has limited success in triple-negative breast cancer (TNBC). In this issue of Cell Metabolism, Wang et al. found that microbial metabolite TMAO boosts CD8 T cell-mediated antitumor immunity by inducing pyroptosis in tumor cells, enhancing the efficacy of immunotherapy in TNBC (Wang et al., 2022).

DOI10.1016/j.cmet.2022.03.003
Alternate JournalCell Metab
PubMed ID35385701