A metagenomic strategy for harnessing the chemical repertoire of the human microbiome.

TitleA metagenomic strategy for harnessing the chemical repertoire of the human microbiome.
Publication TypeJournal Article
Year of Publication2019
AuthorsSugimoto, Y, Camacho, FR, Wang, S, Chankhamjon, P, Odabas, A, Biswas, A, Jeffrey, PD, Donia, MS
JournalScience
Volume366
Issue6471
Date Published2019 12 13
ISSN1095-9203
KeywordsHost Microbial Interactions, Humans, Metagenome, Metagenomics, Microbiota, Multigene Family, Polyketides
Abstract

<p>Extensive progress has been made in determining the effects of the microbiome on human physiology and disease, but the underlying molecules and mechanisms governing these effects remain largely unexplored. Here, we combine a new computational algorithm with synthetic biology to access biologically active small molecules encoded directly in human microbiome-derived metagenomic sequencing data. We discover that members of a clinically used class of molecules are widely encoded in the human microbiome and that they exert potent antibacterial activities against neighboring microbes, implying a possible role in niche competition and host defense. Our approach paves the way toward a systematic unveiling of the chemical repertoire encoded by the human microbiome and provides a generalizable platform for discovering molecular mediators of microbiome-host and microbiome-microbiome interactions.</p>

DOI10.1126/science.aax9176
Alternate JournalScience
PubMed ID31582523
Grant ListDP2 AI124441 / AI / NIAID NIH HHS / United States