Mechanisms of epitranscriptomic gene regulation.

TitleMechanisms of epitranscriptomic gene regulation.
Publication TypeJournal Article
Year of Publication2021
AuthorsSeo, KW, Kleiner, RE
JournalBiopolymers
Volume112
Issue1
Paginatione23403
Date Published2021 Jan
ISSN1097-0282
Abstract

<p>Chemical modifications on RNA can regulate fundamental biological processes. Recent efforts have illuminated the chemical diversity of posttranscriptional ("epitranscriptomic") modifications on eukaryotic messenger RNA and have begun to elucidate their biological roles. In this review, we discuss our current molecular understanding of epitranscriptomic RNA modifications and their effects on gene expression. In particular, we highlight the role of modifications in mediating RNA-protein interactions, RNA structure, and RNA-RNA base pairing, and how these macromolecular interactions control biological processes in the cell.</p>

DOI10.1002/bip.23403
Alternate JournalBiopolymers
PubMed ID33001446
PubMed Central IDPMC7855325
Grant ListR01 GM132189 / GM / NIGMS NIH HHS / United States
MCB-1942565 / / Division of Molecular and Cellular Biosciences /
R01GM132189 / GM / NIGMS NIH HHS / United States