Mechanisms of epitranscriptomic gene regulation.

Publication Year
2021

Type

Journal Article
Abstract

Chemical modifications on RNA can regulate fundamental biological processes. Recent efforts have illuminated the chemical diversity of posttranscriptional ("epitranscriptomic") modifications on eukaryotic messenger RNA and have begun to elucidate their biological roles. In this review, we discuss our current molecular understanding of epitranscriptomic RNA modifications and their effects on gene expression. In particular, we highlight the role of modifications in mediating RNA-protein interactions, RNA structure, and RNA-RNA base pairing, and how these macromolecular interactions control biological processes in the cell.

Journal
Biopolymers
Volume
112
Issue
1
Pages
e23403
Date Published
2021 Jan
ISSN Number
1097-0282
Alternate Journal
Biopolymers
PMCID
PMC7855325
PMID
33001446