| Title | Mechanisms of epitranscriptomic gene regulation. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Seo, KW, Kleiner, RE |
| Journal | Biopolymers |
| Volume | 112 |
| Issue | 1 |
| Pagination | e23403 |
| Date Published | 2021 Jan |
| ISSN | 1097-0282 |
| Keywords | Adenosine, Base Pairing, Cytidine, Gene Expression Regulation, RNA, RNA Processing, Post-Transcriptional, RNA, Messenger |
| Abstract | <p>Chemical modifications on RNA can regulate fundamental biological processes. Recent efforts have illuminated the chemical diversity of posttranscriptional ("epitranscriptomic") modifications on eukaryotic messenger RNA and have begun to elucidate their biological roles. In this review, we discuss our current molecular understanding of epitranscriptomic RNA modifications and their effects on gene expression. In particular, we highlight the role of modifications in mediating RNA-protein interactions, RNA structure, and RNA-RNA base pairing, and how these macromolecular interactions control biological processes in the cell.</p> |
| DOI | 10.1002/bip.23403 |
| Alternate Journal | Biopolymers |
| PubMed ID | 33001446 |
| PubMed Central ID | PMC7855325 |
| Grant List | R01 GM132189 / GM / NIGMS NIH HHS / United States MCB-1942565 / / Division of Molecular and Cellular Biosciences / R01GM132189 / GM / NIGMS NIH HHS / United States |
