Title | Mechanisms of action of ribosomally synthesized and posttranslationally modified peptides (RiPPs). |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Cao, L, Do, T, A Link, J |
Journal | J Ind Microbiol Biotechnol |
Volume | 48 |
Issue | 3-4 |
Date Published | 2021 Jun 04 |
ISSN | 1476-5535 |
Keywords | Biological Products, Humans, Peptides, Protein Biosynthesis, Protein Processing, Post-Translational, Ribosomes |
Abstract | <p>Natural products remain a critical source of medicines and drug leads. One of the most rapidly growing superclasses of natural products is RiPPs: ribosomally synthesized and posttranslationally modified peptides. RiPPs have rich and diverse bioactivities. This review highlights examples of the molecular mechanisms of action that underly those bioactivities. Particular emphasis is placed on RiPP/target interactions for which there is structural information. This detailed mechanism of action work is critical toward the development of RiPPs as therapeutics and can also be used to prioritize hits in RiPP genome mining studies.</p> |
DOI | 10.1093/jimb/kuab005 |
Alternate Journal | J Ind Microbiol Biotechnol |
PubMed ID | 33928382 |
PubMed Central ID | PMC8183687 |
Grant List | R01 GM107036 / GM / NIGMS NIH HHS / United States |