Mechanics of Development.

Publication Year
2021

Type

Journal Article
Abstract

Mechanical forces are integral to development-from the earliest stages of embryogenesis to the construction and differentiation of complex organs. Advances in imaging and biophysical tools have allowed us to delve into the developmental mechanobiology of increasingly complex organs and organisms. Here, we focus on recent work that highlights the diversity and importance of mechanical influences during morphogenesis. Developing tissues experience intrinsic mechanical signals from active forces and changes to tissue mechanical properties as well as extrinsic mechanical signals, including constraint and compression, pressure, and shear forces. Finally, we suggest promising avenues for future work in this rapidly expanding field.

Journal
Dev Cell
Volume
56
Issue
2
Pages
240-250
Date Published
2021 Jan 25
ISSN Number
1878-1551
Alternate Journal
Dev Cell
PMCID
PMC8177046
PMID
33321105