Mechanics of Development.

TitleMechanics of Development.
Publication TypeJournal Article
Year of Publication2021
AuthorsGoodwin, K, Nelson, CM
JournalDev Cell
Date Published2021 01 25
KeywordsAnimals, Biomechanical Phenomena, Biophysics, Cell Differentiation, Embryonic Development, Humans, Mechanotransduction, Cellular, Morphogenesis, Signal Transduction

<p>Mechanical forces are integral to development-from the earliest stages of embryogenesis to the construction and differentiation of complex organs. Advances in imaging and biophysical tools have allowed us to delve into the developmental mechanobiology of increasingly complex organs and organisms. Here, we focus on recent work that highlights the diversity and importance of mechanical influences during morphogenesis. Developing tissues experience intrinsic mechanical signals from active forces and changes to tissue mechanical properties as well as extrinsic mechanical signals, including constraint and compression, pressure, and shear forces. Finally, we suggest promising avenues for future work in this rapidly expanding field.</p>

Alternate JournalDev Cell
PubMed ID33321105
PubMed Central IDPMC8177046
Grant ListR01 HD099030 / HD / NICHD NIH HHS / United States
R01 HL120142 / HL / NHLBI NIH HHS / United States
/ HHMI / Howard Hughes Medical Institute / United States