Mechanics of Development. Author Katharine Goodwin, Celeste Nelson Publication Year 2021 Type Journal Article Abstract Mechanical forces are integral to development-from the earliest stages of embryogenesis to the construction and differentiation of complex organs. Advances in imaging and biophysical tools have allowed us to delve into the developmental mechanobiology of increasingly complex organs and organisms. Here, we focus on recent work that highlights the diversity and importance of mechanical influences during morphogenesis. Developing tissues experience intrinsic mechanical signals from active forces and changes to tissue mechanical properties as well as extrinsic mechanical signals, including constraint and compression, pressure, and shear forces. Finally, we suggest promising avenues for future work in this rapidly expanding field. Keywords Animals, Morphogenesis, Biomechanical Phenomena, Humans, Biophysics, Signal Transduction, Embryonic Development, Cell Differentiation, Mechanotransduction, Cellular Journal Dev Cell Volume 56 Issue 2 Pages 240-250 Date Published 2021 Jan 25 ISSN Number 1878-1551 DOI 10.1016/j.devcel.2020.11.025 Alternate Journal Dev Cell PMCID PMC8177046 PMID 33321105 PubMedPubMed CentralGoogle ScholarBibTeXEndNote X3 XML