Mechanical Control of Cell Differentiation: Insights from the Early Embryo.

TitleMechanical Control of Cell Differentiation: Insights from the Early Embryo.
Publication TypeJournal Article
Year of Publication2022
AuthorsNelson, CM
JournalAnnu Rev Biomed Eng
Volume24
Pagination307-322
Date Published2022 Jun 06
ISSN1545-4274
KeywordsAnimals, Cell Differentiation, Humans, Mice, Regenerative Medicine, Tissue Engineering
Abstract

<p>Differentiation is the process by which a cell activates the expression of tissue-specific genes, downregulates the expression of potency markers, and acquires the phenotypic characteristics of its mature fate. The signals that regulate differentiation include biochemical and mechanical factors within the surrounding microenvironment. We describe recent breakthroughs in our understanding of the mechanical control mechanisms that regulate differentiation, with a specific emphasis on the differentiation events that build the early mouse embryo. Engineering approaches that reproducibly mimic the mechanical regulation of differentiation will permit new insights into early development and applications in regenerative medicine.</p>

DOI10.1146/annurev-bioeng-060418-052527
Alternate JournalAnnu Rev Biomed Eng
PubMed ID35385680
Grant List / HHMI / Howard Hughes Medical Institute / United States