Measuring the repertoire of age-related behavioral changes in Drosophila melanogaster.

TitleMeasuring the repertoire of age-related behavioral changes in Drosophila melanogaster.
Publication TypeJournal Article
Year of Publication2022
AuthorsOverman, KE, Choi, DM, Leung, K, Shaevitz, JW, Berman, GJ
JournalPLoS Comput Biol
Volume18
Issue2
Paginatione1009867
Date Published2022 02
ISSN1553-7358
KeywordsAging, Animals, Behavior, Animal, Drosophila, Drosophila melanogaster, Longevity
Abstract

<p>Aging affects almost all aspects of an organism-its morphology, its physiology, its behavior. Isolating which biological mechanisms are regulating these changes, however, has proven difficult, potentially due to our inability to characterize the full repertoire of an animal's behavior across the lifespan. Using data from fruit flies (D. melanogaster) we measure the full repertoire of behaviors as a function of age. We observe a sexually dimorphic pattern of changes in the behavioral repertoire during aging. Although the stereotypy of the behaviors and the complexity of the repertoire overall remains relatively unchanged, we find evidence that the observed alterations in behavior can be explained by changing the fly's overall energy budget, suggesting potential connections between metabolism, aging, and behavior.</p>

DOI10.1371/journal.pcbi.1009867
Alternate JournalPLoS Comput Biol
PubMed ID35202388
PubMed Central IDPMC8903287
Grant ListR01 GM098090 / GM / NIGMS NIH HHS / United States
R01 MH115831 / MH / NIMH NIH HHS / United States