Mating and male pheromone kill males through distinct mechanisms.

TitleMating and male pheromone kill males through distinct mechanisms.
Publication TypeJournal Article
Year of Publication2017
AuthorsShi, C, Runnels, AM, Murphy, CT
JournalElife
Volume6
Date Published2017 03 14
ISSN2050-084X
KeywordsAnimals, Caenorhabditis, Longevity, Male, Pheromones, Sexual Behavior, Animal
Abstract

<p>Differences in longevity between sexes is a mysterious yet general phenomenon across great evolutionary distances. To test the roles of responses to environmental cues and sexual behaviors in longevity regulation, we examined male lifespan under solitary, grouped, and mated conditions. We find that neurons and the germline are required for male pheromone-dependent male death. Hermaphrodites with a masculinized nervous system secrete male pheromone and are susceptible to male pheromone killing. Male pheromone-mediated killing is unique to androdioecious , and may reduce the number of males in hermaphroditic populations; neither males nor females of gonochoristic species are susceptible to male pheromone killing. By contrast, mating-induced death, which is characterized by germline-dependent shrinking, glycogen loss, and ectopic vitellogenin expression, utilizes distinct molecular pathways and is shared between the sexes and across species. The study of sex- and species-specific regulation of aging reveals deeply conserved mechanisms of longevity and population structure regulation.</p>

DOI10.7554/eLife.23493
Alternate JournalElife
PubMed ID28290982
PubMed Central IDPMC5378475
Grant ListDP1 GM119167 / GM / NIGMS NIH HHS / United States
R01 AG034446 / AG / NIA NIH HHS / United States
T32 GM007388 / GM / NIGMS NIH HHS / United States
/ HHMI / Howard Hughes Medical Institute / United States