Mapping the physiological and molecular markers of stress and SSRI antidepressant treatment in S100a10 corticostriatal neurons.

TitleMapping the physiological and molecular markers of stress and SSRI antidepressant treatment in S100a10 corticostriatal neurons.
Publication TypeJournal Article
Year of Publication2020
AuthorsSargin, D, Chottekalapanda, RU, Perit, KE, Yao, V, Chu, D, Sparks, DW, Kalik, S, Power, SK, Troyanskaya, OG, Schmidt, EF, Greengard, P, Lambe, EK
JournalMol Psychiatry
Volume25
Issue5
Pagination1112-1129
Date Published2020 May
ISSN1476-5578
Abstract

<p>In mood disorders, psychomotor and sensory abnormalities are prevalent, disabling, and intertwined with emotional and cognitive symptoms. Corticostriatal neurons in motor and somatosensory cortex are implicated in these symptoms, yet mechanisms of their vulnerability are unknown. Here, we demonstrate that S100a10 corticostriatal neurons exhibit distinct serotonin responses and have increased excitability, compared with S100a10-negative neurons. We reveal that prolonged social isolation disrupts the specific serotonin response which gets restored by chronic antidepressant treatment. We identify cell-type-specific transcriptional signatures in S100a10 neurons that contribute to serotonin responses and strongly associate with psychomotor and somatosensory function. Our studies provide a strong framework to understand the pathogenesis and create new avenues for the treatment of mood disorders.</p>

DOI10.1038/s41380-019-0473-6
Alternate JournalMol. Psychiatry
PubMed ID31431686
PubMed Central IDPMC7031043
Grant ListPostdoctoral Fellowship / / Alzheimer Society (Société Alzheimer) /
MH090963 / / U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) /
R01 GM071966 / GM / NIGMS NIH HHS / United States
T32 HG003284 / HG / NHGRI NIH HHS / United States
P50 MH090963 / MH / NIMH NIH HHS / United States
R01 NS091722 / NS / NINDS NIH HHS / United States
P30 Center DA035756 / / U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) /
R01NS091722 / / U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) /
R21 NS105047 / NS / NINDS NIH HHS / United States
NARSAD Young Investigator Award / / Brain and Behavior Research Foundation (Brain & Behavior Research Foundation) /