A Map-like Micro-Organization of Grid Cells in the Medial Entorhinal Cortex.

TitleA Map-like Micro-Organization of Grid Cells in the Medial Entorhinal Cortex.
Publication TypeJournal Article
Year of Publication2018
AuthorsGu, Y, Lewallen, S, Kinkhabwala, AA, Domnisoru, C, Yoon, KJ, Gauthier, JL, Fiete, IR, Tank, DW
JournalCell
Volume175
Issue3
Pagination736-750.e30
Date Published2018 10 18
ISSN1097-4172
KeywordsAnimals, Entorhinal Cortex, Grid Cells, Male, Mice, Mice, Inbred C57BL, Nerve Net
Abstract

<p>How the topography of neural circuits relates to their function remains unclear. Although topographic maps exist for sensory and motor variables, they are rarely observed for cognitive variables. Using calcium imaging during virtual navigation, we investigated the relationship between the anatomical organization and functional properties of grid cells, which represent a cognitive code for location during navigation. We found a substantial degree of grid cell micro-organization in mouse medial entorhinal cortex: grid cells and modules all clustered anatomically. Within a module, the layout of grid cells was a noisy two-dimensional lattice in which the anatomical distribution of grid cells largely matched their spatial tuning phases. This micro-arrangement of phases demonstrates the existence of a topographical map encoding a cognitive variable in rodents. It contributes to a foundation for evaluating circuit models of the grid cell network and is consistent with continuous attractor models as the mechanism of grid formation.</p>

DOI10.1016/j.cell.2018.08.066
Alternate JournalCell
PubMed ID30270041
PubMed Central IDPMC6591153
Grant ListR37 NS081242 / NS / NINDS NIH HHS / United States