Title | Machine learning, the kidney, and genotype-phenotype analysis. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Sealfon, RSG, Mariani, LH, Kretzler, M, Troyanskaya, OG |
Journal | Kidney Int |
Volume | 97 |
Issue | 6 |
Pagination | 1141-1149 |
Date Published | 2020 Jun |
ISSN | 1523-1755 |
Keywords | Computational Biology, Genotype, Humans, Kidney, Machine Learning, Phenotype |
Abstract | <p>With biomedical research transitioning into data-rich science, machine learning provides a powerful toolkit for extracting knowledge from large-scale biological data sets. The increasing availability of comprehensive kidney omics compendia (transcriptomics, proteomics, metabolomics, and genome sequencing), as well as other data modalities such as electronic health records, digital nephropathology repositories, and radiology renal images, makes machine learning approaches increasingly essential for analyzing human kidney data sets. Here, we discuss how machine learning approaches can be applied to the study of kidney disease, with a particular focus on how they can be used for understanding the relationship between genotype and phenotype.</p> |
DOI | 10.1016/j.kint.2020.02.028 |
Alternate Journal | Kidney Int |
PubMed ID | 32359808 |
PubMed Central ID | PMC8048707 |
Grant List | K08 DK115891 / DK / NIDDK NIH HHS / United States U24 DK100845 / DK / NIDDK NIH HHS / United States U2C DK114886 / DK / NIDDK NIH HHS / United States UH3 TR002158 / TR / NCATS NIH HHS / United States |