Title | Location is everything: protein translocations as a viral infection strategy. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Cook, KC, Cristea, IM |
Journal | Curr Opin Chem Biol |
Volume | 48 |
Pagination | 34-43 |
Date Published | 2019 02 |
ISSN | 1879-0402 |
Keywords | Animals, Host-Pathogen Interactions, Humans, Microscopy, Organelles, Protein Interaction Maps, Protein Transport, Proteins, Proteomics, Viral Proteins, Virus Diseases, Virus Replication |
Abstract | <p>Protein movement between different subcellular compartments is an essential aspect of biological processes, including transcriptional and metabolic regulation, and immune and stress responses. As obligate intracellular parasites, viruses are master manipulators of cellular composition and organization. Accumulating evidences have highlighted the importance of infection-induced protein translocations between organelles. Both directional and temporal, these translocation events facilitate localization-dependent protein interactions and changes in protein functions that contribute to either host defense or virus replication. The discovery and characterization of protein movement is technically challenging, given the necessity for sensitive detection and subcellular resolution. Here, we discuss infection-induced translocations of host and viral proteins, and the value of integrating quantitative proteomics with advanced microscopy for understanding the biology of human virus infections.</p> |
DOI | 10.1016/j.cbpa.2018.09.021 |
Alternate Journal | Curr Opin Chem Biol |
PubMed ID | 30339987 |
PubMed Central ID | PMC6382524 |
Grant List | R01 GM114141 / GM / NIGMS NIH HHS / United States T32 GM007388 / GM / NIGMS NIH HHS / United States |