Location is everything: protein translocations as a viral infection strategy. Author Katelyn Cook, Ileana Cristea Publication Year 2019 Type Journal Article Abstract Protein movement between different subcellular compartments is an essential aspect of biological processes, including transcriptional and metabolic regulation, and immune and stress responses. As obligate intracellular parasites, viruses are master manipulators of cellular composition and organization. Accumulating evidences have highlighted the importance of infection-induced protein translocations between organelles. Both directional and temporal, these translocation events facilitate localization-dependent protein interactions and changes in protein functions that contribute to either host defense or virus replication. The discovery and characterization of protein movement is technically challenging, given the necessity for sensitive detection and subcellular resolution. Here, we discuss infection-induced translocations of host and viral proteins, and the value of integrating quantitative proteomics with advanced microscopy for understanding the biology of human virus infections. Keywords Animals, Humans, Proteomics, Proteins, Virus Replication, Viral Proteins, Host-Pathogen Interactions, Protein Transport, Microscopy, Protein Interaction Maps, Organelles, Virus Diseases Journal Curr Opin Chem Biol Volume 48 Pages 34-43 Date Published 2019 Feb ISSN Number 1879-0402 DOI 10.1016/j.cbpa.2018.09.021 Alternate Journal Curr Opin Chem Biol PMCID PMC6382524 PMID 30339987 PubMedPubMed CentralGoogle ScholarBibTeXEndNote X3 XML