Lnc-ing ROR1-HER3 and Hippo signalling in metastasis.

Publication Year
2017

Type

Journal Article
Abstract

Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1-HER3 and Hippo-YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.

Journal
Nat Cell Biol
Volume
19
Issue
2
Pages
81-83
Date Published
2017 Jan 31
ISSN Number
1476-4679
Alternate Journal
Nat Cell Biol
PMID
28139652