| Title | Lnc-ing ROR1-HER3 and Hippo signalling in metastasis. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Zhuo, W, Kang, Y |
| Journal | Nat Cell Biol |
| Volume | 19 |
| Issue | 2 |
| Pagination | 81-83 |
| Date Published | 2017 Jan 31 |
| ISSN | 1476-4679 |
| Abstract | <p>Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1-HER3 and Hippo-YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.</p> |
| DOI | 10.1038/ncb3467 |
| Alternate Journal | Nat Cell Biol |
| PubMed ID | 28139652 |
