Liquids, Fibers, and Gels: The Many Phases of Neurodegeneration.

TitleLiquids, Fibers, and Gels: The Many Phases of Neurodegeneration.
Publication TypeJournal Article
Year of Publication2015
AuthorsElbaum-Garfinkle, S, Brangwynne, CP
JournalDev Cell
Volume35
Issue5
Pagination531-532
Date Published2015 Dec 07
ISSN1878-1551
KeywordsAmyotrophic Lateral Sclerosis, Animals, Caenorhabditis elegans Proteins, Frontotemporal Lobar Degeneration, Hydrogels, Motor Activity, Phase Transition, RNA, Messenger, RNA-Binding Protein FUS
Abstract

<p>Recent advances suggest that phase transitions of proteins into liquid or hydrogel states could underlie pathological protein aggregation associated with neurodegenerative disease. In a recent issue of Neuron, Murakami et al. (2015) demonstrate that ALS-associated FUS mutations abrogate the reversibility of condensed liquids and/or hydrogels, leading to neurotoxicity in C. elegans.</p>

DOI10.1016/j.devcel.2015.11.014
Alternate JournalDev. Cell
PubMed ID26651288