Title | Liquids, Fibers, and Gels: The Many Phases of Neurodegeneration. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Elbaum-Garfinkle, S, Brangwynne, CP |
Journal | Dev Cell |
Volume | 35 |
Issue | 5 |
Pagination | 531-532 |
Date Published | 2015 Dec 07 |
ISSN | 1878-1551 |
Keywords | Amyotrophic Lateral Sclerosis, Animals, Caenorhabditis elegans Proteins, Frontotemporal Lobar Degeneration, Hydrogels, Motor Activity, Phase Transition, RNA, Messenger, RNA-Binding Protein FUS |
Abstract | <p>Recent advances suggest that phase transitions of proteins into liquid or hydrogel states could underlie pathological protein aggregation associated with neurodegenerative disease. In a recent issue of Neuron, Murakami et al. (2015) demonstrate that ALS-associated FUS mutations abrogate the reversibility of condensed liquids and/or hydrogels, leading to neurotoxicity in C. elegans.</p> |
DOI | 10.1016/j.devcel.2015.11.014 |
Alternate Journal | Dev Cell |
PubMed ID | 26651288 |