| Title | Liquids, Fibers, and Gels: The Many Phases of Neurodegeneration. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Elbaum-Garfinkle, S, Brangwynne, CP |
| Journal | Dev Cell |
| Volume | 35 |
| Issue | 5 |
| Pagination | 531-532 |
| Date Published | 2015 Dec 07 |
| ISSN | 1878-1551 |
| Keywords | Amyotrophic Lateral Sclerosis, Animals, Caenorhabditis elegans Proteins, Frontotemporal Lobar Degeneration, Hydrogels, Motor Activity, Phase Transition, RNA, Messenger, RNA-Binding Protein FUS |
| Abstract | <p>Recent advances suggest that phase transitions of proteins into liquid or hydrogel states could underlie pathological protein aggregation associated with neurodegenerative disease. In a recent issue of Neuron, Murakami et al. (2015) demonstrate that ALS-associated FUS mutations abrogate the reversibility of condensed liquids and/or hydrogels, leading to neurotoxicity in C. elegans.</p> |
| DOI | 10.1016/j.devcel.2015.11.014 |
| Alternate Journal | Dev Cell |
| PubMed ID | 26651288 |
