Lineage tracing reveals metastatic dynamics.

TitleLineage tracing reveals metastatic dynamics.
Publication TypeJournal Article
Year of Publication2021
AuthorsLee, E, Kang, Y
JournalCancer Cell
Volume39
Issue8
Pagination1050-1052
Date Published2021 Aug 09
ISSN1878-3686
Abstract

<p>Combining single-cell lineage tracing with RNA sequencing has provided unprecedented opportunities to prospectively explore metastatic dynamics in vivo. In this issue of Cancer Cell, Simeonov et al. developed the macsGESTALT lineage recording system to reveal that hybrid EMT states and S100 expression are associated with elevated metastatic abilities in a pancreatic cancer model.</p>

DOI10.1016/j.ccell.2021.06.005
Alternate JournalCancer Cell
PubMed ID34171265