Title | Left-Right Patterning: Breaking Symmetry to Asymmetric Morphogenesis. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Grimes, DT, Burdine, RD |
Journal | Trends Genet |
Volume | 33 |
Issue | 9 |
Pagination | 616-628 |
Date Published | 2017 09 |
ISSN | 0168-9525 |
Keywords | Animals, Body Patterning, Morphogenesis |
Abstract | <p>Vertebrates exhibit striking left-right (L-R) asymmetries in the structure and position of the internal organs. Symmetry is broken by motile cilia-generated asymmetric fluid flow, resulting in a signaling cascade - the Nodal-Pitx2 pathway - being robustly established within mesodermal tissue on the left side only. This pathway impinges upon various organ primordia to instruct their side-specific development. Recently, progress has been made in understanding both the breaking of embryonic L-R symmetry and how the Nodal-Pitx2 pathway controls lateralized cell differentiation, migration, and other aspects of cell behavior, as well as tissue-level mechanisms, that drive asymmetries in organ formation. Proper execution of asymmetric organogenesis is critical to health, making furthering our understanding of L-R development an important concern.</p> |
DOI | 10.1016/j.tig.2017.06.004 |
Alternate Journal | Trends Genet |
PubMed ID | 28720483 |
PubMed Central ID | PMC5764106 |
Grant List | R01 HD048584 / HD / NICHD NIH HHS / United States |