Latent versus productive infection: the alpha herpesvirus switch.

TitleLatent versus productive infection: the alpha herpesvirus switch.
Publication TypeJournal Article
Year of Publication2018
AuthorsKoyuncu, OO, MacGibeny, MA, Enquist, LW
JournalFuture Virol
Volume13
Issue6
Pagination431-443
Date Published2018 May
ISSN1746-0794
Abstract

Alpha herpesviruses are common pathogens of mammals. They establish a productive infection in many cell types, but a life-long latent infection occurs in PNS neurons. A vast majority of the human population has latent HSV-1 infections. Currently, there is no cure to clear latent infections. Even though HSV-1 is among the best studied viral pathogens, regulation of latency and reactivation is not well understood due to several challenges including a lack of animal models that precisely recapitulate latency/reactivation episodes; a difficulty in modeling latency; and a limited understanding of neuronal biology. In this review, we discuss insights gained from latency models with a focus on the neuronal and viral factors that determine the mode of infection.

DOI10.2217/fvl-2018-0023
Alternate JournalFuture Virol
PubMed ID29967651
PubMed Central IDPMC6021814
Grant ListF30 NS090640 / NS / NINDS NIH HHS / United States
R01 NS033506 / NS / NINDS NIH HHS / United States
R01 NS060699 / NS / NINDS NIH HHS / United States
R37 NS033506 / NS / NINDS NIH HHS / United States