Lamin post-translational modifications: emerging toggles of nuclear organization and function.

TitleLamin post-translational modifications: emerging toggles of nuclear organization and function.
Publication TypeJournal Article
Year of Publication2021
AuthorsMurray-Nerger, LA, Cristea, IM
JournalTrends Biochem Sci
Volume46
Issue10
Pagination832-847
Date Published2021 10
ISSN0968-0004
KeywordsCell Nucleus, Chromatin, Humans, Lamins, Protein Processing, Post-Translational
Abstract

<p>Nuclear lamins are ancient type V intermediate filaments with diverse functions that include maintaining nuclear shape, mechanosignaling, tethering and stabilizing chromatin, regulating gene expression, and contributing to cell cycle progression. Despite these numerous roles, an outstanding question has been how lamins are regulated. Accumulating work indicates that a range of lamin post-translational modifications (PTMs) control their functions both in homeostatic cells and in disease states such as progeria, muscular dystrophy, and viral infection. Here, we review the current knowledge of the diverse types of PTMs that regulate lamins in a site-specific manner. We highlight methods that can be used to characterize lamin PTMs whose functions are currently unknown and provide a perspective on the future of the lamin PTM field.</p>

DOI10.1016/j.tibs.2021.05.007
Alternate JournalTrends Biochem Sci
PubMed ID34148760
Grant ListT32 GM007388 / GM / NIGMS NIH HHS / United States