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Virulence

  • 1.
    Zhao A, Bodine S, Xie Q, Wang B, Ram G, Novick R, Muir T. Reconstitution of the quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesis. Proc Natl Acad Sci U S A. 2022;119(33):e2202661119. PMCID: PMC9388083
    Reference Link
  • 1.
    Simanek K, Taylor I, Richael E, Lasek-Nesselquist E, Bassler B, Paczkowski J. The PqsE-RhlR Interaction Regulates RhlR DNA Binding to Control Virulence Factor Production in . Microbiol Spectr. 2022;10(1):e0210821. PMCID: PMC8754118
    Reference Link
  • 1.
    Behnke M, Khan A, Lauron E, Jimah J, Wang Q, Tolia N, Sibley D. Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii. PLoS Genet. 2015;11(8):e1005434. PMCID: PMC4546408
    Reference Link
  • 1.
    Ellison C, Dalia T, Klancher C, Shaevitz J, Gitai Z, Dalia A. Acinetobacter baylyi regulates type IV pilus synthesis by employing two extension motors and a motor protein inhibitor. Nat Commun. 2021;12(1):3744. PMCID: PMC8213720
    Reference Link
  • 1.
    Scheffler R, Sugimoto Y, Bratton B, Ellison C, Koch M, Donia M, Gitai Z. Pseudomonas aeruginosa detachment from surfaces via a self-made small molecule. J Biol Chem. 2021;296:100279. PMCID: PMC7949062
    Reference Link
  • 1.
    Mashruwala A, Bassler B. The Vibrio cholerae Quorum-Sensing Protein VqmA Integrates Cell Density, Environmental, and Host-Derived Cues into the Control of Virulence. mBio. 2020;11(4). PMCID: PMC7387800
    Reference Link
  • 1.
    Mukherjee S, Jemielita M, Stergioula V, Tikhonov M, Bassler B. Photosensing and quorum sensing are integrated to control Pseudomonas aeruginosa collective behaviors. PLoS Biol. 2019;17(12):e3000579. PMCID: PMC6932827
    Reference Link
  • 1.
    Moore G, Gitai Z. Both clinical and environmental Caulobacter species are virulent in the Galleria mellonella infection model. PLoS One. 2020;15(3):e0230006. PMCID: PMC7067423
    Reference Link
  • 1.
    Bridges A, Bassler B. The intragenus and interspecies quorum-sensing autoinducers exert distinct control over Vibrio cholerae biofilm formation and dispersal. PLoS Biol. 2019;17(11):e3000429. PMCID: PMC6872173
    Reference Link
  • 1.
    Silpe J, Bassler B. A Host-Produced Quorum-Sensing Autoinducer Controls a Phage Lysis-Lysogeny Decision. Cell. 2019;176(1-2):268–280.e13. PMCID: PMC6329655
    Reference Link
  • 1.
    Xie Q, Zhao A, Jeffrey P, Kim M, Bassler B, Stone H, Novick R, Muir T. Identification of a Molecular Latch that Regulates Staphylococcal Virulence. Cell Chem Biol. 2019;26(4):548–558.e4. PMCID: PMC6506218
    Reference Link
  • 1.
    Laval K, Vernejoul J, Van Cleemput J, Koyuncu O, Enquist L. Virulent Pseudorabies Virus Infection Induces a Specific and Lethal Systemic Inflammatory Response in Mice. J Virol. 2018;92(24). PMCID: PMC6258956
    Reference Link
  • 1.
    Klaus J, Deay J, Neuenswander B, Hursh W, Gao Z, Bouddhara T, Williams T, Douglas J, Monize K, Martins P, Majerczyk C, Seyedsayamdost M, Peterson B, Rivera M, Chandler J. Malleilactone Is a Burkholderia pseudomallei Virulence Factor Regulated by Antibiotics and Quorum Sensing. J Bacteriol. 2018;200(14). PMCID: PMC6018353
    Reference Link
  • 1.
    Mao D, Bushin L, Moon K, Wu Y, Seyedsayamdost M. Discovery of as a global regulator of secondary metabolism and virulence in E264. Proc Natl Acad Sci U S A. 2017;114(14):E2920-E2928. PMCID: PMC5389298
    Reference Link
  • 1.
    Mukherjee S, Moustafa D, Smith C, Goldberg J, Bassler B. The RhlR quorum-sensing receptor controls Pseudomonas aeruginosa pathogenesis and biofilm development independently of its canonical homoserine lactone autoinducer. PLoS Pathog. 2017;13(7):e1006504. PMCID: PMC5531660
    Reference Link
  • 1.
    Wang B, Zhao A, Xie Q, Olinares P, Chait B, Novick R, Muir T. Functional Plasticity of the AgrC Receptor Histidine Kinase Required for Staphylococcal Virulence. Cell Chem Biol. 2017;24(1):76–86. PMCID: PMC5697745
    Reference Link
  • 1.
    Paczkowski J, Mukherjee S, McCready A, Cong J-P, Aquino C, Kim H, Henke B, Smith C, Bassler B. Flavonoids Suppress Virulence through Allosteric Inhibition of Quorum-sensing Receptors. J Biol Chem. 2017;292(10):4064–4076. PMCID: PMC5354481
    Reference Link
  • 1.
    Bartlett T, Bratton B, Duvshani A, Miguel A, Sheng Y, Martin N, Nguyen J, Persat A, Desmarais S, VanNieuwenhze M, Huang K, Zhu J, Shaevitz J, Gitai Z. A Periplasmic Polymer Curves Vibrio cholerae and Promotes Pathogenesis. Cell. 2017;168(1-2):172–185.e15. PMCID: PMC5287421
    Reference Link
  • 1.
    Wang B, Muir T. Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles. Cell Chem Biol. 2016;23(2):214–224. PMCID: PMC4847544
    Reference Link
  • 1.
    Inclan Y, Persat A, Greninger A, Von Dollen J, Johnson J, Krogan N, Gitai Z, Engel J. A scaffold protein connects type IV pili with the Chp chemosensory system to mediate activation of virulence signaling in Pseudomonas aeruginosa. Mol Microbiol. 2016;101(4):590–605. PMCID: PMC4980298
    Reference Link
  • 1.
    Wang B, Zhao A, Novick R, Muir T. Key driving forces in the biosynthesis of autoinducing peptides required for staphylococcal virulence. Proc Natl Acad Sci U S A. 2015;112(34):10679–84. PMCID: PMC4553796
    Reference Link
  • 1.
    Joyce E, Bassler B, Wright A. Evidence for a signaling system in Helicobacter pylori: detection of a luxS-encoded autoinducer. J Bacteriol. 2000;182(13):3638–43. PMCID: PMC94532
    Reference Link
  • 1.
    Miller M, Bassler B. Quorum sensing in bacteria. Annu Rev Microbiol. 2001;55:165–99. PMID: 11544353
    Reference Link
  • 1.
    Miller M, Skorupski K, Lenz D, Taylor R, Bassler B. Parallel quorum sensing systems converge to regulate virulence in Vibrio cholerae. Cell. 2002;110(3):303–14. PMID: 12176318
    Reference Link
  • 1.
    Zhu J, Miller M, Vance R, Dziejman M, Bassler B, Mekalanos J. Quorum-sensing regulators control virulence gene expression in Vibrio cholerae. Proc Natl Acad Sci U S A. 2002;99(5):3129–34. PMCID: PMC122484
    Reference Link
  • 1.
    Lenz D, Mok K, Lilley B, Kulkarni R, Wingreen N, Bassler B. The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae. Cell. 2004;118(1):69–82. PMID: 15242645
    Reference Link
  • 1.
    Camilli A, Bassler B. Bacterial small-molecule signaling pathways. Science. 2006;311(5764):1113–6. PMCID: PMC2776824
    Reference Link
  • 1.
    Hammer B, Bassler B. Regulatory small RNAs circumvent the conventional quorum sensing pathway in pandemic Vibrio cholerae. Proc Natl Acad Sci U S A. 2007;104(27):11145–9. PMCID: PMC1888797
    Reference Link
  • 1.
    Hammer B, Bassler B. Distinct sensory pathways in Vibrio cholerae El Tor and classical biotypes modulate cyclic dimeric GMP levels to control biofilm formation. J Bacteriol. 2009;191(1):169–77. PMCID: PMC2612459
    Reference Link
  • 1.
    Chen G, Swem L, Swem D, Stauff D, O’Loughlin C, Jeffrey P, Bassler B, Hughson F. A strategy for antagonizing quorum sensing. Mol Cell. 2011;42(2):199–209. PMCID: PMC3092643
    Reference Link
  • 1.
    Ng W-L, Perez L, Cong J, Semmelhack M, Bassler B. Broad spectrum pro-quorum-sensing molecules as inhibitors of virulence in vibrios. PLoS Pathog. 2012;8(6):e1002767. PMCID: PMC3386246
    Reference Link
  • 1.
    O’Loughlin C, Miller L, Siryaporn A, Drescher K, Semmelhack M, Bassler B. A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation. Proc Natl Acad Sci U S A. 2013;110(44):17981–6. PMCID: PMC3816427
    Reference Link

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