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Tumor Microenvironment

  • 1.
    Zhao H, Teng D, Yang L, Xu X, Chen J, Jiang T, Feng A, Zhang Y, Frederick D, Gu L, Cai L, Asara J, di Magliano M, Boland G, Flaherty K, Swanson K, Liu D, Rabinowitz J, Zheng B. Myeloid-derived itaconate suppresses cytotoxic CD8 T cells and promotes tumour growth. Nat Metab. 2022;4(12):1660–1673. PMID: 36376563
    Reference Link
  • 1.
    Shen M, Kang Y. Cancer fitness genes: emerging therapeutic targets for metastasis. Trends Cancer. 2023;9(1):69–82. PMID: 36184492
    Reference Link
  • 1.
    Meng J, Jiang Y-Z, Zhao S, Tao Y, Zhang T, Wang X, Zhang Y, Sun K, Yuan M, Chen J, Wei Y, Lan X, Chen M, David C, Chang Z, Guo X, Pan D, Chen M, Shao Z-M, Kang Y, Zheng H. Tumor-derived Jagged1 promotes cancer progression through immune evasion. Cell Rep. 2022;38(10):110492. PMID: 35263601
    Reference Link
  • 1.
    Kang Y, Kuperwasser C. Evolving barcodes shed light into evolving metastases. Dev Cell. 2021;56(8):1077–1079. PMID: 33878297
    Reference Link
  • 1.
    Phan T, Nguyen V, Buettner R, Morales C, Yang L, Wong P, Tsai W, Salazar M, Gil Z, Diamond D, Rabinowitz J, Rosen S, Melstrom L. Inhibition of pyrimidine synthesis augments Gemcitabine induced growth inhibition in an immunocompetent model of pancreatic cancer. Int J Biol Sci. 2021;17(9):2240–2251. PMCID: PMC8241727
    Reference Link
  • 1.
    Rabie E, Zhang S, Dunn C, Nelson C. Substratum stiffness signals through integrin-linked kinase and β1-integrin to regulate midbody proteins and abscission during EMT. Mol Biol Cell. 2021;32(18):1664–1676. PMCID: PMC8684726
    Reference Link
  • 1.
    Chen F, Han Y, Kang Y. Bone marrow niches in the regulation of bone metastasis. Br J Cancer. 2021;124(12):1912–1920. PMCID: PMC8184962
    Reference Link
  • 1.
    Rabie E, Zhang S, Kourouklis A, Kilinc N, Simi A, Radisky D, Tien J, Nelson C. Matrix degradation and cell proliferation are coupled to promote invasion and escape from an engineered human breast microtumor. Integr Biol (Camb). 2021;13(1):17–29. PMCID: PMC7856634
    Reference Link
  • 1.
    Shen M, Kang Y. Stresses in the metastatic cascade: molecular mechanisms and therapeutic opportunities. Genes Dev. 2020;34(23-24):1577–1598. PMCID: PMC7706714
    Reference Link
  • 1.
    Ringel A, Drijvers J, Baker G, Catozzi A, García-Cañaveras J, Gassaway B, Miller B, Juneja V, Nguyen T, Joshi S, Yao C-H, Yoon H, Sage P, LaFleur M, Trombley J, Jacobson C, Maliga Z, Gygi S, Sorger P, Rabinowitz J, Sharpe A, Haigis M. Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell. 2020;183(7):1848–1866.e26. PMCID: PMC8064125
    Reference Link
  • 1.
    Anlas A, Nelson C. Soft Microenvironments Induce Chemoresistance by Increasing Autophagy Downstream of Integrin-Linked Kinase. Cancer Res. 2020;80(19):4103–4113. PMCID: PMC7534696
    Reference Link
  • 1.
    Pham K, Huynh D, Le L, Delitto D, Yang L, Huang J, Kang Y, Steinberg M, Li J, Zhang L, Liu D, Tang M-S, Liu C, Wang H. E-cigarette promotes breast carcinoma progression and lung metastasis: Macrophage-tumor cells crosstalk and the role of CCL5 and VCAM-1. Cancer Lett. 2020;491:132–145. PMCID: PMC9703643
    Reference Link
  • 1.
    García-Cañaveras J, Chen L, Rabinowitz J. The Tumor Metabolic Microenvironment: Lessons from Lactate. Cancer Res. 2019;79(13):3155–3162. PMCID: PMC6606343
    Reference Link
  • 1.
    Shen M, Kang Y. Complex interplay between tumor microenvironment and cancer therapy. Front Med. 2018;12(4):426–439. PMID: 30097962
    Reference Link
  • 1.
    Shen M, Kang Y. pSTAT3 Reactive Astrocytes Promote Brain Metastasis. Trends Mol Med. 2018;24(9):733–735. PMID: 30029985
    Reference Link
  • 1.
    Celià-Terrassa T, Kang Y. Metastatic niche functions and therapeutic opportunities. Nat Cell Biol. 2018;20(8):868–877. PMCID: 4161226
    Reference Link
  • 1.
    Simi A, Anlas A, Stallings-Mann M, Zhang S, Hsia T, Cichon M, Radisky D, Nelson C. A Soft Microenvironment Protects from Failure of Midbody Abscission and Multinucleation Downstream of the EMT-Promoting Transcription Factor Snail. Cancer Res. 2018;78(9):2277–2289. PMCID: PMC5932229
    Reference Link
  • 1.
    Esposito M, Guise T, Kang Y. The Biology of Bone Metastasis. Cold Spring Harb Perspect Med. 2018;8(6). PMCID: PMC5980796
    Reference Link
  • 1.
    Liu D, Kang Y. Ets2 anchors the prometastatic function of mutant p53 in osteosarcoma. Genes Dev. 2017;31(18):1823–1824. PMCID: PMC5695082
    Reference Link
  • 1.
    Zhang Y, Kurupati R, Liu L, Zhou X, Zhang G, Hudaihed A, Filisio F, Giles-Davis W, Xu X, Karakousis G, Schuchter L, Xu W, Amaravadi R, Xiao M, Sadek N, Krepler C, Herlyn M, Freeman G, Rabinowitz J, Ertl H. Enhancing CD8 T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. Cancer Cell. 2017;32(3):377–391.e9. PMCID: PMC5751418
    Reference Link
  • 1.
    Celià-Terrassa T, Liu D, Choudhury A, Hang X, Wei Y, Zamalloa J, Alfaro-Aco R, Chakrabarti R, Jiang Y-Z, Koh B, Smith H, DeCoste C, Li J-J, Shao Z-M, Kang Y. Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axis. Nat Cell Biol. 2017;19(6):711–723. PMCID: PMC5481166
    Reference Link
  • 1.
    Peinado H, Zhang H, Matei I, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan R, Bromberg J, Kang Y, Bissell M, Cox T, Giaccia A, Erler J, Hiratsuka S, Ghajar C, Lyden D. Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer. 2017;17(5):302–317. PMID: 28303905
    Reference Link
  • 1.
    Ren G, Esposito M, Kang Y. Bone metastasis and the metastatic niche. J Mol Med (Berl). 2015;93(11):1203–12. PMCID: PMC4636917
    Reference Link
  • 1.
    Pang M-F, Siedlik M, Han S, Stallings-Mann M, Radisky D, Nelson C. Tissue Stiffness and Hypoxia Modulate the Integrin-Linked Kinase ILK to Control Breast Cancer Stem-like Cells. Cancer Res. 2016;76(18):5277–87. PMCID: PMC5026611
    Reference Link
  • 1.
    Alečković M, Kang Y. Welcoming Treat: Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis. Cancer Cell. 2015;28(5):554–556. PMID: 26555172
    Reference Link
  • 1.
    Li Z, Kang Y. Emerging therapeutic targets in metastatic progression: A focus on breast cancer. Pharmacol Ther. 2016;161:79–96. PMCID: PMC4851893
    Reference Link

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