Department of Molecular Biology

Off screen link: Skip to content Off screen link: Skip to search
Princeton University
Home

Main Menu

  • Department
    Department
    • Chair’s Welcome
    • Administration & Staff
    • Associated Programs, Institutes & Departments
    • Grants Submission Policy & Funding Opportunities
    • Open Positions
    • MolBio Retreat 2024
      • MolBio Retreat 2024 Schedule
  • Faculty & Research
    Faculty & Research
    • Faculty
    • Research Areas
      • Biochemistry, Biophysics & Structural Biology
      • Cell Biology, Development & Cancer
      • Genetics & Genomics
      • Microbiology, Virology & Immunology
      • Quantitative & Computational Biology
  • Postdoc
    Postdoc
    • Overview
    • Prospective Postdoc
    • New Postdoc
    • Postdoc Community
    • Career Development
    • Lewis-Sigler Fellows
    • Contacts
  • Graduate
    Graduate
    • Overview
    • Admission & Financial Support
    • Requirements
    • Courses
    • MD/PhD Program
    • MolBio Scholars
    • Outreach Program
    • Faculty Graduate Committee
    • Department Life
      • Life in the Department
      • Graduate Student Committees
      • Career Resources
      • Student Life
      • Incoming Graduate Students
    • Molecular Biology Training Grants
  • Undergraduate
    Undergraduate
    • Overview
    • Teaching Mission
    • Major
      • Major Requirements
      • Departmentals
      • Declare a Major
      • Typical Paths
      • Courses
      • Minor & Certificate Programs
      • Study Abroad
      • Junior Independent Work
      • Senior Thesis
    • Research
      • Current Lab Assignments
      • Summer Research
      • Sophomore Research Course
      • Internship Milestone Credit
      • Undergraduate Publications
    • Career Resources
    • Community
      • Undergraduate Community
      • Important Dates and Deadlines
      • Class Day
    • Contacts
  • Core Facilities
    Core Facilities
    • Overview
    • Shared Imaging Facilities
      • Confocal Microscopy
        • Instruments
        • Fluorescent Dyes
        • ILab Calendar and Service Requests
        • User Training
        • Nikon Center of Excellence
        • Contact
      • Electron Microscopy
        • Equipment
        • Pricing
        • Contacts
      • Imaging & Analysis Center
      • Nikon Center of Excellence
    • Shared Research Facilities
      • Biophysics
      • Drosophila Media
      • Flow Cytometry
        • Facility Use
        • Instruments
        • ILab Calendar and Service Requests
        • Contact
      • Genome Editing Shared Resource (Rutgers-CINJ)
      • Histology
      • Lab Animal Resources
      • Macromolecular Crystallography
      • NMR Facility
      • Proteomics & Mass Spec
        • Proteomics & MS Services
        • Protocols & Guidelines
      • Research Computing
      • Sequencing & Microarray
      • Synseq
    • Other Facilities
      • IT Support
      • Facilities & Maintenance
      • Environmental Health & Safety (EHS)
  • Community
    Community
    • DEI Committee
    • Code of Conduct
  • Apply & Visit
  • Contact
  • People
  • Donors
  • News
  • Events
    • Events Archive

Search

S-Adenosylmethionine

  • 1.
    Clark K, Covington B, Seyedsayamdost M. Biosynthesis-guided discovery reveals enteropeptins as alternative sactipeptides containing N-methylornithine. Nat Chem. 2022;14(12):1390–1398. PMID: 36316408
    Reference Link
  • 1.
    Clark K, Seyedsayamdost M. Bioinformatic Atlas of Radical SAM Enzyme-Modified RiPP Natural Products Reveals an Isoleucine-Tryptophan Crosslink. J Am Chem Soc. 2022;144(39):17876–17888. PMID: 36128669
    Reference Link
  • 1.
    Bushin L, Covington B, Clark K, Caruso A, Seyedsayamdost M. Bicyclostreptins are radical SAM enzyme-modified peptides with unique cyclization motifs. Nat Chem Biol. 2022;18(10):1135–1143. PMCID: 6686864
    Reference Link
  • 1.
    Caruso A, Seyedsayamdost M. Radical SAM Enzyme QmpB Installs Two 9-Membered Ring Sactionine Macrocycles during Biogenesis of a Ribosomal Peptide Natural Product. J Org Chem. 2021;86(16):11284–11289. PMID: 34351169
    Reference Link
  • 1.
    Balo A, Caruso A, Tao L, Tantillo D, Seyedsayamdost M, Britt D. Trapping a cross-linked lysine-tryptophan radical in the catalytic cycle of the radical SAM enzyme SuiB. Proc Natl Acad Sci U S A. 2021;118(21). PMCID: PMC8166192
    Reference Link
  • 1.
    Caruso A, Bushin L, Clark K, Martinie R, Seyedsayamdost M. Radical Approach to Enzymatic β-Thioether Bond Formation. J Am Chem Soc. 2019;141(2):990–997. PMID: 30521328
    Reference Link
  • 1.
    Bushin L, Clark K, Pelczer I, Seyedsayamdost M. Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif. J Am Chem Soc. 2018;140(50):17674–17684. PMID: 30398325
    Reference Link
  • 1.
    Caruso A, Martinie R, Bushin L, Seyedsayamdost M. Macrocyclization via an Arginine-Tyrosine Crosslink Broadens the Reaction Scope of Radical -Adenosylmethionine Enzymes. J Am Chem Soc. 2019;141(42):16610–16614. PMID: 31596076
    Reference Link
  • 1.
    Clark K, Bushin L, Seyedsayamdost M. Aliphatic Ether Bond Formation Expands the Scope of Radical SAM Enzymes in Natural Product Biosynthesis. J Am Chem Soc. 2019;141(27):10610–10615. PMID: 31246011
    Reference Link
  • 1.
    Bushin L, Seyedsayamdost M. Guidelines for Determining the Structures of Radical SAM Enzyme-Catalyzed Modifications in the Biosynthesis of RiPP Natural Products. Methods Enzymol. 2018;606:439–460. PMID: 30097102
    Reference Link
  • 1.
    Schramma K, Seyedsayamdost M. Lysine-Tryptophan-Crosslinked Peptides Produced by Radical SAM Enzymes in Pathogenic Streptococci. ACS Chem Biol. 2017;12(4):922–927. PMID: 28191919
    Reference Link
  • 1.
    Davis K, Schramma K, Hansen W, Bacik J, Khare S, Seyedsayamdost M, Ando N. Structures of the peptide-modifying radical SAM enzyme SuiB elucidate the basis of substrate recognition. Proc Natl Acad Sci U S A. 2017;114(39):10420–10425. PMCID: PMC5625900
    Reference Link
  • 1.
    Schauder S, Shokat K, Surette M, Bassler B. The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule. Mol Microbiol. 2001;41(2):463–76. PMID: 11489131
    Reference Link
  • 1.
    Wei Y, Perez L, Ng W-L, Semmelhack M, Bassler B. Mechanism of Vibrio cholerae autoinducer-1 biosynthesis. ACS Chem Biol. 2011;6(4):356–65. PMCID: PMC3077805
    Reference Link

Footer

Connect with Mol Bio

  • Facebook
  • Twitter

Department of Molecular Biology
119 Lewis Thomas Laboratory
Washington Road
Princeton, NJ 08544-1014
Need help? Contact us

Visitor Parking Information

Intranet Login

Privacy Notice

Explore

  • Graduate Program
  • Undergraduate Program
  • Summer Undergraduate Research Program (SURP)
  • Research Areas
  • Molecular Biology Faculty
  • Faculty Research Labs

Core Facilities & Instruments

  • Biophysics
  • Confocal Microscopy
  • Drosophila Media
  • Electron Microscopy
  • Flow Cytometry
  • Histology
  • Imaging Facility at LSI
  • Laboratory Animal Resources
  • Macromolecular Crystallography
  • Nikon Center of Excellence
  • Proteomics & Mass Spectrometry
  • Sequencing & Microarray
  • Synseq

Programs & Institutes

  • Graduate Program in Quantitative and Computational Biology
  • Glenn Laboratories For Aging Research
  • Lewis-Sigler Institute for Integrative Genomics
  • Princeton Neuroscience Institute
  • Diversity & Non-Discrimination
  • Accessibility Help

© 2025 The Trustees of Princeton University

Princeton University