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RNA-Binding Proteins

  • 1.
    Li H, Gavis E. Drosophila FMRP controls miR-276-mediated regulation of nejire mRNA for space-filling dendrite development. G3 (Bethesda). 2022;12(11). PMCID: PMC9635640
    Reference Link
  • 1.
    Chen H, Zhan M, Liu J, Liu Z, Shen M, Yang F, Kang Y, Yin F, Li Z. Structure-Based Design, Optimization, and Evaluation of Potent Stabilized Peptide Inhibitors Disrupting MTDH and SND1 Interaction. J Med Chem. 2022;65(18):12188–12199. PMID: 36044768
    Reference Link
  • 1.
    Roden C, Dai Y, Giannetti C, Seim I, Lee M, Sealfon R, McLaughlin G, Boerneke M, Iserman C, Wey S, Ekena J, Troyanskaya O, Weeks K, You L, Chilkoti A, Gladfelter A. Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures. Nucleic Acids Res. 2022;50(14):8168–8192. PMCID: PMC9371935
    Reference Link
  • 1.
    Peng Y, Gavis E. The Drosophila hnRNP F/H homolog Glorund recruits dFMRP to inhibit nanos translation elongation. Nucleic Acids Res. 2022;50(12):7067–7083. PMCID: PMC9262583
    Reference Link
  • 1.
    Shen M, Wei Y, Kim H, Wan L, Jiang Y-Z, Hang X, Raba M, Remiszewski S, Rowicki M, Wu C-G, Wu S, Zhang L, Lu X, Yuan M, Smith H, Zheng A, Bertino J, Jin J, Xing Y, Shao Z-M, Kang Y. Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis. Nat Cancer. 2022;3(1):43–59. PMCID: PMC8818087
    Reference Link
  • 1.
    Shen M, Smith H, Wei Y, Jiang Y-Z, Zhao S, Wang N, Rowicki M, Tang Y, Hang X, Wu S, Wan L, Shao Z-M, Kang Y. Pharmacological disruption of the MTDH-SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer. Nat Cancer. 2022;3(1):60–74. PMCID: PMC8818088
    Reference Link
  • 1.
    Nilsson-Payant B, tenOever B, Velthuis A. The Host Factor ANP32A Is Required for Influenza A Virus vRNA and cRNA Synthesis. J Virol. 2022;96(4):e0209221. PMCID: PMC8865535
    Reference Link
  • 1.
    Fodor E, Velthuis A. Structure and Function of the Influenza Virus Transcription and Replication Machinery. Cold Spring Harb Perspect Med. 2020;10(9). PMCID: PMC7334866
    Reference Link
  • 1.
    Maerker M, Getwan M, Dowdle M, McSheene J, Gonzalez V, Pelliccia J, Hamilton D, Yartseva V, Vejnar C, Tingler M, Minegishi K, Vick P, Giraldez A, Hamada H, Burdine R, Sheets M, Blum M, Schweickert A. Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5. Nat Commun. 2021;12(1):5482. PMCID: PMC8446035
    Reference Link
  • 1.
    Colonnetta M, Lym L, Wilkins L, Kappes G, Castro E, Ryder P, Schedl P, Lerit D, Deshpande G. Antagonism between and Torso receptor regulates transcriptional quiescence underlying germline/soma distinction. Elife. 2021;10. PMCID: PMC7843132
    Reference Link
  • 1.
    Park C, Zhou J, Wong A, Chen K, Theesfeld C, Darnell R, Troyanskaya O. Genome-wide landscape of RNA-binding protein target site dysregulation reveals a major impact on psychiatric disorder risk. Nat Genet. 2021;53(2):166–173. PMCID: PMC7886016
    Reference Link
  • 1.
    Alizzi R, Xu D, Tenenbaum C, Wang W, Gavis E. The ELAV/Hu protein Found in neurons regulates cytoskeletal and ECM adhesion inputs for space-filling dendrite growth. PLoS Genet. 2020;16(12):e1009235. PMCID: PMC7793258
    Reference Link
  • 1.
    Shen M, Xie S, Rowicki M, Michel S, Wei Y, Hang X, Wan L, Lu X, Yuan M, Jin J, Jaschinski F, Zhou T, Klar R, Kang Y. Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis. Cancer Res. 2021;81(4):1014–1025. PMCID: PMC8026491
    Reference Link
  • 1.
    Riback J, Zhu L, Ferrolino M, Tolbert M, Mitrea D, Sanders D, Wei M-T, Kriwacki R, Brangwynne C. Composition-dependent thermodynamics of intracellular phase separation. Nature. 2020;581(7807):209–214. PMCID: PMC7733533
    Reference Link
  • 1.
    Richter F, Morton S, Kim S, Kitaygorodsky A, Wasson L, Chen K, Zhou J, Qi H, Patel N, DePalma S, Parfenov M, Homsy J, Gorham J, Manheimer K, Velinder M, Farrell A, Marth G, Schadt E, Kaltman J, Newburger J, Giardini A, Goldmuntz E, Brueckner M, Kim R, Porter G, Bernstein D, Chung W, Srivastava D, Tristani-Firouzi M, Troyanskaya O, Dickel D, Shen Y, Seidman J, Seidman C, Gelb B. Genomic analyses implicate noncoding de novo variants in congenital heart disease. Nat Genet. 2020;52(8):769–777. PMCID: PMC7415662
    Reference Link
  • 1.
    Arey R, Kaletsky R, Murphy C. Nervous system-wide profiling of presynaptic mRNAs reveals regulators of associative memory. Sci Rep. 2019;9(1):20314. PMCID: PMC6937282
    Reference Link
  • 1.
    Seo K, Kleiner R. YTHDF2 Recognition of N-Methyladenosine (mA)-Modified RNA Is Associated with Transcript Destabilization. ACS Chem Biol. 2020;15(1):132–139. PMCID: PMC7025767
    Reference Link
  • 1.
    Arguello E, Leach R, Kleiner R. Selection with a Site-Specifically Modified RNA Library Reveals the Binding Preferences of N-Methyladenosine Reader Proteins. Biochemistry. 2019;58(31):3386–3395. PMCID: PMC6684389
    Reference Link
  • 1.
    Barr J, Gilmutdinov R, Wang L, Shidlovskii Y ii, Schedl P. The CPEB Protein Orb Specifies Oocyte Fate by a 3’UTR-Dependent Autoregulatory Loop. Genetics. 2019;213(4):1431–1446. PMCID: PMC6893371
    Reference Link
  • 1.
    Kobren S, Singh M. Systematic domain-based aggregation of protein structures highlights DNA-, RNA- and other ligand-binding positions. Nucleic Acids Res. 2019;47(2):582–593. PMCID: PMC6344845
    Reference Link
  • 1.
    Barr J, Charania S, Gilmutdinov R, Yakovlev K, Shidlovskii Y ii, Schedl P. The CPEB translational regulator, Orb, functions together with Par proteins to polarize the Drosophila oocyte. PLoS Genet. 2019;15(3):e1008012. PMCID: PMC6433291
    Reference Link
  • 1.
    Arguello E, Srikumar T, Kleiner R. A Photocrosslinking-Based RNA Chemical Proteomics Approach to Profile m A-Regulated Protein-RNA Interactions. Curr Protoc Nucleic Acid Chem. 2018;75(1):e69. PMID: 30408339
    Reference Link
  • 1.
    Gilbertson S, Federspiel J, Hartenian E, Cristea I, Glaunsinger B. Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription. Elife. 2018;7. PMCID: PMC6203436
    Reference Link
  • 1.
    Adamson B, Smogorzewska A, Sigoillot F, King R, Elledge S. A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nat Cell Biol. 2012;14(3):318–28. PMCID: PMC3290715
    Reference Link
  • 1.
    Niepielko M, Eagle W, Gavis E. Stochastic Seeding Coupled with mRNA Self-Recruitment Generates Heterogeneous Drosophila Germ Granules. Curr Biol. 2018;28(12):1872–1881.e3. PMCID: PMC6008217
    Reference Link
  • 1.
    Arguello E, DeLiberto A, Kleiner R. RNA Chemical Proteomics Reveals the N-Methyladenosine (mA)-Regulated Protein-RNA Interactome. J Am Chem Soc. 2017;139(48):17249–17252. PMID: 29140688
    Reference Link
  • 1.
    Morscher R, Ducker G, Li S, Mayer J, Gitai Z, Sperl W, Rabinowitz J. Mitochondrial translation requires folate-dependent tRNA methylation. Nature. 2018;554(7690):128–132. PMCID: PMC6020024
    Reference Link
  • 1.
    Li Q, Yan C, Xu H, Wang Z, Long J, Li W, Wu J, Yin P, Yan N. Examination of the dimerization states of the single-stranded RNA recognition protein pentatricopeptide repeat 10 (PPR10). J Biol Chem. 2014;289(45):31503–12. PMCID: PMC4223348
    Reference Link
  • 1.
    Tamayo J, Teramoto T, Chatterjee S, Hall T, Gavis E. The Drosophila hnRNP F/H Homolog Glorund Uses Two Distinct RNA-Binding Modes to Diversify Target Recognition. Cell Rep. 2017;19(1):150–161. PMCID: PMC5392723
    Reference Link
  • 1.
    Pritykin Y, Brito T, Schüpbach T, Singh M, Pane A. Integrative analysis unveils new functions for the Cutoff protein in noncoding RNA biogenesis and gene regulation. RNA. 2017;23(7):1097–1109. PMCID: PMC5473144
    Reference Link
  • 1.
    Li Y, Banerjee S, Goldstein S, Dong B, Gaughan C, Rath S, Donovan J, Korennykh A, Silverman R, Weiss S. Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line. Elife. 2017;6. PMCID: PMC5404912
    Reference Link
  • 1.
    Wang Q, Taliaferro M, Klibaite U, Hilgers V, Shaevitz J, Rio D. The PSI-U1 snRNP interaction regulates male mating behavior in Drosophila. Proc Natl Acad Sci U S A. 2016;113(19):5269–74. PMCID: PMC4868454
    Reference Link
  • 1.
    Hung G, Flint S. Normal human cell proteins that interact with the adenovirus type 5 E1B 55kDa protein. Virology. 2017;504:12–24. PMCID: PMC5337154
    Reference Link
  • 1.
    Bhogal B, Plaza-Jennings A, Gavis E. Nanos-mediated repression of hid protects larval sensory neurons after a global switch in sensitivity to apoptotic signals. Development. 2016;143(12):2147–59. PMCID: PMC4920170
    Reference Link
  • 1.
    Viktorovskaya O, Greco T, Cristea I, Thompson S. Identification of RNA Binding Proteins Associated with Dengue Virus RNA in Infected Cells Reveals Temporally Distinct Host Factor Requirements. PLoS Negl Trop Dis. 2016;10(8):e0004921. PMCID: PMC4996428
    Reference Link
  • 1.
    Zhang H, Elbaum-Garfinkle S, Langdon E, Taylor N, Occhipinti P, Bridges A, Brangwynne C, Gladfelter A. RNA Controls PolyQ Protein Phase Transitions. Mol Cell. 2015;60(2):220–30. PMCID: PMC5221516
    Reference Link
  • 1.
    Little S, Sinsimer K, Lee J, Wieschaus E, Gavis E. Independent and coordinate trafficking of single Drosophila germ plasm mRNAs. Nat Cell Biol. 2015;17(5):558–68. PMCID: PMC4417036
    Reference Link
  • 1.
    Petry S, Vale R. A new cap for kinetochore fibre minus ends. Nat Cell Biol. 2011;13(12):1389–91. PMCID: PMC3532025
    Reference Link
  • 1.
    Olesnicky E, Killian D, Garcia E, Morton M, Rathjen A, Sola I, Gavis E. Extensive use of RNA-binding proteins in Drosophila sensory neuron dendrite morphogenesis. G3 (Bethesda). 2014;4(2):297–306. PMCID: PMC3931563
    Reference Link

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