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Quorum Sensing

  • 1.
    Silpe J, Duddy O, Bassler B. Natural and synthetic inhibitors of a phage-encoded quorum-sensing receptor affect phage-host dynamics in mixed bacterial communities. Proc Natl Acad Sci U S A. 2022;119(49):e2217813119. PMCID: PMC9894119
    Reference Link
  • 1.
    Prentice J, Bridges A, Bassler B. Synergy between c-di-GMP and Quorum-Sensing Signaling in Vibrio cholerae Biofilm Morphogenesis. J Bacteriol. 2022;204(10):e0024922. PMCID: PMC9578409
    Reference Link
  • 1.
    Mashruwala A, Qin B, Bassler B. Quorum-sensing- and type VI secretion-mediated spatiotemporal cell death drives genetic diversity in Vibrio cholerae. Cell. 2022;185(21):3966–3979.e13. PMCID: PMC9623500
    Reference Link
  • 1.
    Qin B, Bassler B. Quorum-sensing control of matrix protein production drives fractal wrinkling and interfacial localization of Vibrio cholerae pellicles. Nat Commun. 2022;13(1):6063. PMCID: PMC9561665
    Reference Link
  • 1.
    Taylor I, Murray-Nerger L, Greco T, Liu D, Cristea I, Bassler B. Protein Interaction Networks of Catalytically Active and Catalytically Inactive PqsE in Pseudomonas aeruginosa. mBio. 2022;13(5):e0155922. PMCID: PMC9600345
    Reference Link
  • 1.
    Zhao A, Bodine S, Xie Q, Wang B, Ram G, Novick R, Muir T. Reconstitution of the quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesis. Proc Natl Acad Sci U S A. 2022;119(33):e2202661119. PMCID: PMC9388083
    Reference Link
  • 1.
    Taylor I, Jeffrey P, Moustafa D, Goldberg J, Bassler B. The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against . Biochemistry. 2022;61(17):1894–1903. PMCID: PMC9454246
    Reference Link
  • 1.
    Bridges A, Prentice J, Wingreen N, Bassler B. Signal Transduction Network Principles Underlying Bacterial Collective Behaviors. Annu Rev Microbiol. 2022;76:235–257. PMCID: PMC9463083
    Reference Link
  • 1.
    Høyland-Kroghsbo N, Bassler B. Phage Infection Restores PQS Signaling and Enhances Growth of a Pseudomonas aeruginosa Quorum-Sensing Mutant. J Bacteriol. 2022;204(5):e0055721. PMCID: PMC9112912
    Reference Link
  • 1.
    Eickhoff M, Fei C, Cong J-P, Bassler B. LuxT Is a Global Regulator of Low-Cell-Density Behaviors, Including Type III Secretion, Siderophore Production, and Aerolysin Production, in Vibrio harveyi. mBio. 2022;13(1):e0362121. PMCID: PMC8764538
    Reference Link
  • 1.
    Simanek K, Taylor I, Richael E, Lasek-Nesselquist E, Bassler B, Paczkowski J. The PqsE-RhlR Interaction Regulates RhlR DNA Binding to Control Virulence Factor Production in . Microbiol Spectr. 2022;10(1):e0210821. PMCID: PMC8754118
    Reference Link
  • 1.
    Jemielita M, Mashruwala A, Valastyan J, Wingreen N, Bassler B. Secreted Proteases Control the Timing of Aggregative Community Formation in Vibrio cholerae. mBio. 2021;12(6):e0151821. PMCID: PMC8609355
    Reference Link
  • 1.
    Yang J, Sanfilippo J, Abbasi N, Gitai Z, Bassler B, Stone H. Evidence for biosurfactant-induced flow in corners and bacterial spreading in unsaturated porous media. Proc Natl Acad Sci U S A. 2021;118(38). PMCID: PMC8463848
    Reference Link
  • 1.
    Duddy O, Huang X, Silpe J, Bassler B. Mechanism underlying the DNA-binding preferences of the Vibrio cholerae and vibriophage VP882 VqmA quorum-sensing receptors. PLoS Genet. 2021;17(7):e1009550. PMCID: PMC8284805
    Reference Link
  • 1.
    Narla A, Borenstein D, Wingreen N. A biophysical limit for quorum sensing in biofilms. Proc Natl Acad Sci U S A. 2021;118(21). PMCID: PMC8166027
    Reference Link
  • 1.
    Valastyan J, Kraml C, Pelczer I, Ferrante T, Bassler B. Saccharomyces cerevisiae Requires To Produce 4-Hydroxy-5-Methylfuran-3(2H)-One, a Mimic of the Bacterial Quorum-Sensing Autoinducer AI-2. mBio. 2021;12(2). PMCID: PMC8092285
    Reference Link
  • 1.
    Rued B, Covington B, Bushin L, Szewczyk G, Laczkovich I, Seyedsayamdost M, Federle M. Quorum Sensing in Streptococcus mutans Regulates Production of Tryglysin, a Novel RaS-RiPP Antimicrobial Compound. mBio. 2021;12(2). PMCID: PMC8092268
    Reference Link
  • 1.
    Taylor I, Paczkowski J, Jeffrey P, Henke B, Smith C, Bassler B. Inhibitor Mimetic Mutations in the PqsE Enzyme Reveal a Protein-Protein Interaction with the Quorum-Sensing Receptor RhlR That Is Vital for Virulence Factor Production. ACS Chem Biol. 2021;16(4):740–752. PMCID: PMC8056388
    Reference Link
  • 1.
    Eickhoff M, Fei C, Huang X, Bassler B. LuxT controls specific quorum-sensing-regulated behaviors in Vibrionaceae spp. via repression of qrr1, encoding a small regulatory RNA. PLoS Genet. 2021;17(4):e1009336. PMCID: PMC8043402
    Reference Link
  • 1.
    Wong G, Antani J, Lele P, Chen J, Nan B, Kühn M, Persat A, Bru J-L, Høyland-Kroghsbo N, Siryaporn A, Conrad J, Carrara F, Yawata Y, Stocker R, Brun Y, Whitfield G, Lee C, de Anda J, Schmidt W, Golestanian R, O’Toole G, Floyd K, Yildiz F, Yang S, Jin F, Toyofuku M, Eberl L, Nomura N, Zacharoff L, El-Naggar M, Yalcin S, Malvankar N, Rojas-Andrade M, Hochbaum A, Yan J, Stone H, Wingreen N, Bassler B, Wu Y, Xu H, Drescher K, Dunkel J. Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation. Phys Biol. 2021;18(5). PMCID: PMC8506656
    Reference Link
  • 1.
    Duddy O, Bassler B. Quorum sensing across bacterial and viral domains. PLoS Pathog. 2021;17(1):e1009074. PMCID: PMC7790227
    Reference Link
  • 1.
    Vrla G, Esposito M, Zhang C, Kang Y, Seyedsayamdost M, Gitai Z. Cytotoxic alkyl-quinolones mediate surface-induced virulence in Pseudomonas aeruginosa. PLoS Pathog. 2020;16(9):e1008867. PMCID: PMC7515202
    Reference Link
  • 1.
    Xie Q, Wiedmann M, Zhao A, Pagan I, Novick R, Suga H, Muir T. Discovery of quorum quenchers targeting the membrane-embedded sensor domain of the receptor histidine kinase, AgrC. Chem Commun (Camb). 2020;56(76):11223–11226. PMCID: PMC7530097
    Reference Link
  • 1.
    Mashruwala A, Bassler B. The Vibrio cholerae Quorum-Sensing Protein VqmA Integrates Cell Density, Environmental, and Host-Derived Cues into the Control of Virulence. mBio. 2020;11(4). PMCID: PMC7387800
    Reference Link
  • 1.
    Mukherjee S, Jemielita M, Stergioula V, Tikhonov M, Bassler B. Photosensing and quorum sensing are integrated to control Pseudomonas aeruginosa collective behaviors. PLoS Biol. 2019;17(12):e3000579. PMCID: PMC6932827
    Reference Link
  • 1.
    Jemielita M, Wingreen N, Bassler B. Quorum sensing controls multicellular aggregate formation. Elife. 2018;7. PMCID: PMC6351105
    Reference Link
  • 1.
    McCready A, Paczkowski J, Henke B, Bassler B. Structural determinants driving homoserine lactone ligand selection in the LasR quorum-sensing receptor. Proc Natl Acad Sci U S A. 2019;116(1):245–254. PMCID: PMC6320529
    Reference Link
  • 1.
    Rossine F, Martinez-Garcia R, Sgro A, Gregor T, Tarnita C. Eco-evolutionary significance of "loners". PLoS Biol. 2020;18(3):e3000642. PMCID: PMC7081983
    Reference Link
  • 1.
    Silpe J, Bridges A, Huang X, Coronado D, Duddy O, Bassler B. Separating Functions of the Phage-Encoded Quorum-Sensing-Activated Antirepressor Qtip. Cell Host Microbe. 2020;27(4):629–641.e4. PMCID: PMC7148176
    Reference Link
  • 1.
    Huang X, Duddy O, Silpe J, Paczkowski J, Cong J, Henke B, Bassler B. Mechanism underlying autoinducer recognition in the DPO-VqmA quorum-sensing pathway. J Biol Chem. 2020;295(10):2916–2931. PMCID: PMC7062168
    Reference Link
  • 1.
    Bushin L, Clark K, Pelczer I, Seyedsayamdost M. Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif. J Am Chem Soc. 2018;140(50):17674–17684. PMID: 30398325
    Reference Link
  • 1.
    Bridges A, Bassler B. The intragenus and interspecies quorum-sensing autoinducers exert distinct control over Vibrio cholerae biofilm formation and dispersal. PLoS Biol. 2019;17(11):e3000429. PMCID: PMC6872173
    Reference Link
  • 1.
    Silpe J, Bassler B. A Host-Produced Quorum-Sensing Autoinducer Controls a Phage Lysis-Lysogeny Decision. Cell. 2019;176(1-2):268–280.e13. PMCID: PMC6329655
    Reference Link
  • 1.
    Chuang S, Vrla G, Fröhlich K, Gitai Z. Surface association sensitizes Pseudomonas aeruginosa to quorum sensing. Nat Commun. 2019;10(1):4118. PMCID: PMC6739362
    Reference Link
  • 1.
    McCready A, Paczkowski J, Cong J-P, Bassler B. An autoinducer-independent RhlR quorum-sensing receptor enables analysis of RhlR regulation. PLoS Pathog. 2019;15(6):e1007820. PMCID: PMC6564026
    Reference Link
  • 1.
    Mukherjee S, Bassler B. Bacterial quorum sensing in complex and dynamically changing environments. Nat Rev Microbiol. 2019;17(6):371–382. PMCID: PMC6615036
    Reference Link
  • 1.
    Xie Q, Zhao A, Jeffrey P, Kim M, Bassler B, Stone H, Novick R, Muir T. Identification of a Molecular Latch that Regulates Staphylococcal Virulence. Cell Chem Biol. 2019;26(4):548–558.e4. PMCID: PMC6506218
    Reference Link
  • 1.
    Paczkowski J, McCready A, Cong J-P, Li Z, Jeffrey P, Smith C, Henke B, Hughson F, Bassler B. An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor. ACS Chem Biol. 2019;14(3):378–389. PMCID: PMC6601336
    Reference Link
  • 1.
    Mukherjee S, Moustafa D, Stergioula V, Smith C, Goldberg J, Bassler B. The PqsE and RhlR proteins are an autoinducer synthase-receptor pair that control virulence and biofilm development in . Proc Natl Acad Sci U S A. 2018;115(40):E9411-E9418. PMCID: PMC6176596
    Reference Link
  • 1.
    Eickhoff M, Bassler B. SnapShot: Bacterial Quorum Sensing. Cell. 2018;174(5):1328–1328.e1. PMID: 30142348
    Reference Link
  • 1.
    McRose D, Baars O, Seyedsayamdost M, Morel F. Quorum sensing and iron regulate a two-for-one siderophore gene cluster in . Proc Natl Acad Sci U S A. 2018;115(29):7581–7586. PMCID: PMC6055174
    Reference Link
  • 1.
    Klaus J, Deay J, Neuenswander B, Hursh W, Gao Z, Bouddhara T, Williams T, Douglas J, Monize K, Martins P, Majerczyk C, Seyedsayamdost M, Peterson B, Rivera M, Chandler J. Malleilactone Is a Burkholderia pseudomallei Virulence Factor Regulated by Antibiotics and Quorum Sensing. J Bacteriol. 2018;200(14). PMCID: PMC6018353
    Reference Link
  • 1.
    Wang R, Gallant Étienne, Seyedsayamdost M. Investigation of the Genetics and Biochemistry of Roseobacticide Production in the Roseobacter Clade Bacterium Phaeobacter inhibens. mBio. 2016;7(2):e02118. PMCID: PMC4807370
    Reference Link
  • 1.
    Mukherjee S, Moustafa D, Smith C, Goldberg J, Bassler B. The RhlR quorum-sensing receptor controls Pseudomonas aeruginosa pathogenesis and biofilm development independently of its canonical homoserine lactone autoinducer. PLoS Pathog. 2017;13(7):e1006504. PMCID: PMC5531660
    Reference Link
  • 1.
    Hurley A, Bassler B. Asymmetric regulation of quorum-sensing receptors drives autoinducer-specific gene expression programs in Vibrio cholerae. PLoS Genet. 2017;13(5):e1006826. PMCID: PMC5467912
    Reference Link
  • 1.
    Kim M, Zhao A, Wang A, Brown Z, Muir T, Stone H, Bassler B. Surface-attached molecules control Staphylococcus aureus quorum sensing and biofilm development. Nat Microbiol. 2017;2:17080. PMCID: PMC5526357
    Reference Link
  • 1.
    Papenfort K, Silpe J, Schramma K, Cong J-P, Seyedsayamdost M, Bassler B. A Vibrio cholerae autoinducer-receptor pair that controls biofilm formation. Nat Chem Biol. 2017;13(5):551–557. PMCID: PMC5391282
    Reference Link
  • 1.
    Wang B, Zhao A, Xie Q, Olinares P, Chait B, Novick R, Muir T. Functional Plasticity of the AgrC Receptor Histidine Kinase Required for Staphylococcal Virulence. Cell Chem Biol. 2017;24(1):76–86. PMCID: PMC5697745
    Reference Link
  • 1.
    Høyland-Kroghsbo N, Paczkowski J, Mukherjee S, Broniewski J, Westra E, Bondy-Denomy J, Bassler B. Quorum sensing controls the Pseudomonas aeruginosa CRISPR-Cas adaptive immune system. Proc Natl Acad Sci U S A. 2017;114(1):131–135. PMCID: PMC5224376
    Reference Link
  • 1.
    Paczkowski J, Mukherjee S, McCready A, Cong J-P, Aquino C, Kim H, Henke B, Smith C, Bassler B. Flavonoids Suppress Virulence through Allosteric Inhibition of Quorum-sensing Receptors. J Biol Chem. 2017;292(10):4064–4076. PMCID: PMC5354481
    Reference Link

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