Department of Molecular Biology

Off screen link: Skip to content Off screen link: Skip to search
Princeton University
Home

Main Menu

  • Department
    Department
    • Chair’s Welcome
    • Administration & Staff
    • Associated Programs, Institutes & Departments
    • Grants Submission Policy & Funding Opportunities
    • Open Positions
    • MolBio Retreat 2024
      • MolBio Retreat 2024 Schedule
  • Faculty & Research
    Faculty & Research
    • Faculty
    • Research Areas
      • Biochemistry, Biophysics & Structural Biology
      • Cell Biology, Development & Cancer
      • Genetics & Genomics
      • Microbiology, Virology & Immunology
      • Quantitative & Computational Biology
  • Postdoc
    Postdoc
    • Overview
    • Prospective Postdoc
    • New Postdoc
    • Postdoc Community
    • Career Development
    • Lewis-Sigler Fellows
    • Contacts
  • Graduate
    Graduate
    • Overview
    • Admission & Financial Support
    • Requirements
    • Courses
    • MD/PhD Program
    • MolBio Scholars
    • Outreach Program
    • Faculty Graduate Committee
    • Department Life
      • Life in the Department
      • Graduate Student Committees
      • Career Resources
      • Student Life
      • Incoming Graduate Students
    • Molecular Biology Training Grants
  • Undergraduate
    Undergraduate
    • Overview
    • Teaching Mission
    • Major
      • Major Requirements
      • Departmentals
      • Declare a Major
      • Typical Paths
      • Courses
      • Minor & Certificate Programs
      • Study Abroad
      • Junior Independent Work
      • Senior Thesis
    • Research
      • Current Lab Assignments
      • Summer Research
      • Sophomore Research Course
      • Internship Milestone Credit
      • Undergraduate Publications
    • Career Resources
    • Community
      • Undergraduate Community
      • Important Dates and Deadlines
      • Class Day
    • Contacts
  • Core Facilities
    Core Facilities
    • Overview
    • Shared Imaging Facilities
      • Confocal Microscopy
        • Instruments
        • Fluorescent Dyes
        • ILab Calendar and Service Requests
        • User Training
        • Nikon Center of Excellence
        • Contact
      • Electron Microscopy
        • Equipment
        • Pricing
        • Contacts
      • Imaging & Analysis Center
      • Nikon Center of Excellence
    • Shared Research Facilities
      • Biophysics
      • Drosophila Media
      • Flow Cytometry
        • Facility Use
        • Instruments
        • ILab Calendar and Service Requests
        • Contact
      • Genome Editing Shared Resource (Rutgers-CINJ)
      • Histology
      • Lab Animal Resources
      • Macromolecular Crystallography
      • NMR Facility
      • Proteomics & Mass Spec
        • Proteomics & MS Services
        • Protocols & Guidelines
      • Research Computing
      • Sequencing & Microarray
      • Synseq
    • Other Facilities
      • IT Support
      • Facilities & Maintenance
      • Environmental Health & Safety (EHS)
  • Community
    Community
    • DEI Committee
    • Code of Conduct
  • Apply & Visit
  • Contact
  • People
  • Donors
  • News
  • Events
    • Events Archive

Search

Phosphorylation

  • 1.
    Farahani P, Lemke S, Dine E, Uribe G, Toettcher J, Nelson C. Substratum stiffness regulates Erk signaling dynamics through receptor-level control. Cell Rep. 2021;37(13):110181. PMCID: PMC8756379
    Reference Link
  • 1.
    Justice J, Kennedy M, Hutton J, Liu D, Song B, Phelan B, Cristea I. Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity. Sci Adv. 2021;7(25). PMCID: PMC8213230
    Reference Link
  • 1.
    Dine E, Reed E, Toettcher J. Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch. Cell Rep. 2021;35(12):109280. PMCID: PMC8292983
    Reference Link
  • 1.
    Schild T, McReynolds M, Shea C, Low V, Schaffer B, Asara J, Piskounova E, Dephoure N, Rabinowitz J, Gomes A, Blenis J. NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma. Cell Rep. 2021;35(11):109238. PMID: 34133937
    Reference Link
  • 1.
    Song B, Liu D, Greco T, Cristea I. Post-translational modification control of viral DNA sensors and innate immune signaling. Adv Virus Res. 2021;109:163–199. PMCID: PMC8489191
    Reference Link
  • 1.
    Zhang Y, Hughson F. Chaperoning SNARE Folding and Assembly. Annu Rev Biochem. 2021;90:581–603. PMCID: PMC8900292
    Reference Link
  • 1.
    Marmion R, Yang L, Goyal Y, Jindal G, Wetzel J, Singh M, Schüpbach T, Shvartsman S. Molecular mechanisms underlying cellular effects of human MEK1 mutations. Mol Biol Cell. 2021;32(9):974–983. PMCID: PMC8108529
    Reference Link
  • 1.
    Wong S, Hepowit N, Port S, Yau R, Peng Y, Azad N, Habib A, Harpaz N, Schuldiner M, Hughson F, MacGurn J, Weisman L. Cargo Release from Myosin V Requires the Convergence of Parallel Pathways that Phosphorylate and Ubiquitylate the Cargo Adaptor. Curr Biol. 2020;30(22):4399–4412.e7. PMCID: PMC8025699
    Reference Link
  • 1.
    Montalbán-López M, Scott T, Ramesh S, Rahman I, van Heel A, Viel J, Bandarian V, Dittmann E, Genilloud O, Goto Y, Burgos M, Hill C, Kim S, Koehnke J, Latham J, Link J, Martínez B, Nair S, Nicolet Y, Rebuffat S, Sahl H-G, Sareen D, Schmidt E, Schmitt L, Severinov K, Süssmuth R, Truman A, Wang H, Weng J-K, van Wezel G, Zhang Q, Zhong J, Piel J, Mitchell D, Kuipers O, van der Donk W. New developments in RiPP discovery, enzymology and engineering. Nat Prod Rep. 2021;38(1):130–239. PMCID: PMC7864896
    Reference Link
  • 1.
    Ledo J, Zhang R, Mesin L, Mourão-Sá D, Azevedo E, Troyanskaya O, Bustos V, Greengard P. Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development. PLoS One. 2020;15(8):e0237773. PMCID: PMC7444478
    Reference Link
  • 1.
    Ledo J, Liebmann T, Zhang R, Chang J, Azevedo E, Wong E, Silva H, Troyanskaya O, Bustos V, Greengard P. Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia. Mol Psychiatry. 2021;26(10):5620–5635. PMCID: PMC7881060
    Reference Link
  • 1.
    Mukherjee S, Jemielita M, Stergioula V, Tikhonov M, Bassler B. Photosensing and quorum sensing are integrated to control Pseudomonas aeruginosa collective behaviors. PLoS Biol. 2019;17(12):e3000579. PMCID: PMC6932827
    Reference Link
  • 1.
    Tareen A, Wingreen N, Mukhopadhyay R. Asymmetry between Activators and Deactivators in Functional Protein Networks. Sci Rep. 2020;10(1):10131. PMCID: PMC7311538
    Reference Link
  • 1.
    Song B, Greco T, Lum K, Taber C, Cristea I. The DNA Sensor cGAS is Decorated by Acetylation and Phosphorylation Modifications in the Context of Immune Signaling. Mol Cell Proteomics. 2020;19(7):1193–1208. PMCID: PMC7338091
    Reference Link
  • 1.
    Kinoshita N, Hashimoto Y, Yasue N, Suzuki M, Cristea I, Ueno N. Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis. Cell Rep. 2020;30(11):3875–3888.e3. PMID: 32187556
    Reference Link
  • 1.
    Goglia A, Wilson M, Jena S, Silbert J, Basta L, Devenport D, Toettcher J. A Live-Cell Screen for Altered Erk Dynamics Reveals Principles of Proliferative Control. Cell Syst. 2020;10(3):240–253.e6. PMCID: PMC7540725
    Reference Link
  • 1.
    Yeung E, McFann S, Marsh L, Dufresne E, Filippi S, Harrington H, Shvartsman S, Wühr M. Inference of Multisite Phosphorylation Rate Constants and Their Modulation by Pathogenic Mutations. Curr Biol. 2020;30(5):877–882.e6. PMCID: PMC7085240
    Reference Link
  • 1.
    Paul S, Yang L, Mattingly H, Goyal Y, Shvartsman S, Veraksa A. Activation-induced substrate engagement in ERK signaling. Mol Biol Cell. 2020;31(4):235–243. PMCID: PMC7183763
    Reference Link
  • 1.
    Albig C, Wang C, Dann G, Wojcik F, Schauer T, Krause S, Maenner S, Cai W, Li Y, Girton J, Muir T, Johansen J, Johansen K, Becker P, Regnard C. JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila. Nat Commun. 2019;10(1):5343. PMCID: PMC6877644
    Reference Link
  • 1.
    Patel A, Yeung E, McGuire S, Wu A, Toettcher J, Burdine R, Shvartsman S. Optimizing photoswitchable MEK. Proc Natl Acad Sci U S A. 2019;116(51):25756–25763. PMCID: PMC6926043
    Reference Link
  • 1.
    Chen S, Shenk T, Nogalski M. P2Y2 purinergic receptor modulates virus yield, calcium homeostasis, and cell motility in human cytomegalovirus-infected cells. Proc Natl Acad Sci U S A. 2019;116(38):18971–18982. PMCID: PMC6754545
    Reference Link
  • 1.
    Kachaev Z, Lebedeva L, Shaposhnikov A, Moresco J, Yates J, Schedl P, Shidlovskii Y. Paip2 cooperates with Cbp80 at an active promoter and participates in RNA Polymerase II phosphorylation in Drosophila. FEBS Lett. 2019;593(10):1102–1112. PMCID: PMC6538421
    Reference Link
  • 1.
    Hashimoto Y, Kinoshita N, Greco T, Federspiel J, Beltran P, Ueno N, Cristea I. Mechanical Force Induces Phosphorylation-Mediated Signaling that Underlies Tissue Response and Robustness in Xenopus Embryos. Cell Syst. 2019;8(3):226–241.e7. PMCID: PMC6453581
    Reference Link
  • 1.
    Yan R, Zhang J, Park H-J, Park E, Oh S, Zheng H, Junn E, Voronkov M, Stock J, Mouradian M. Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson’s disease and DLB. Proc Natl Acad Sci U S A. 2018;115(51):E12053-E12062. PMCID: PMC6304960
    Reference Link
  • 1.
    O’Connell B, Adamson B, Lydeard J, Sowa M, Ciccia A, Bredemeyer A, Schlabach M, Gygi S, Elledge S, Harper W. A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell. 2010;40(4):645–57. PMCID: PMC3006237
    Reference Link
  • 1.
    Aguilera-Gomez A, Zacharogianni M, van Oorschot M, Genau H, Grond R, Veenendaal T, Sinsimer K, Gavis E, Behrends C, Rabouille C. Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation. Cell Rep. 2017;20(4):935–948. PMCID: PMC6064189
    Reference Link
  • 1.
    Presler M, Van Itallie E, Klein A, Kunz R, Coughlin M, Peshkin L, Gygi S, Wühr M, Kirschner M. Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the egg. Proc Natl Acad Sci U S A. 2017;114(50):E10838-E10847. PMCID: PMC5740657
    Reference Link
  • 1.
    Asam K, Staniszewski A, Zhang H, Melideo S, Mazzeo A, Voronkov M, Huber K, Pérez E, Stock M, Stock J, Arancio O, Nicholls R. Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer’s disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid. PLoS One. 2017;12(12):e0189413. PMCID: PMC5734769
    Reference Link
  • 1.
    Park H-J, Lee K-W, Oh S, Yan R, Zhang J, Beach T, Adler C, Voronkov M, Braithwaite S, Stock J, Mouradian M. Protein Phosphatase 2A and Its Methylation Modulating Enzymes LCMT-1 and PME-1 Are Dysregulated in Tauopathies of Progressive Supranuclear Palsy and Alzheimer Disease. J Neuropathol Exp Neurol. 2018;77(2):139–148. PMCID: PMC6251692
    Reference Link
  • 1.
    Xie T, Ren R, Zhang Y- yuan, Pang Y, Yan C, Gong X, He Y, Li W, Miao D, Hao Q, Deng H, Wang Z, Wu J-W, Yan N. Molecular mechanism for inhibition of a critical component in the Arabidopsis thaliana abscisic acid signal transduction pathways, SnRK2.6, by protein phosphatase ABI1. J Biol Chem. 2012;287(1):794–802. PMCID: PMC3249133
    Reference Link
  • 1.
    Smith J, Hall A, Rose M. Membrane curvature directs the localization of Cdc42p to novel foci required for cell-cell fusion. J Cell Biol. 2017;216(12):3971–3980. PMCID: PMC5716282
    Reference Link
  • 1.
    Jindal G, Goyal Y, Humphreys J, Yeung E, Tian K, Patterson V, He H, Burdine R, Goldsmith E, Shvartsman S. How activating mutations affect MEK1 regulation and function. J Biol Chem. 2017;292(46):18814–18820. PMCID: PMC5704466
    Reference Link
  • 1.
    Wilson M, Ravindran P, Lim W, Toettcher J. Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control. Mol Cell. 2017;67(5):757–769.e5. PMCID: PMC5591080
    Reference Link
  • 1.
    Jin L, Chun J, Pan C, Alesi G, Li D, Magliocca K, Kang Y, Chen Z, Shin D, Khuri F, Fan J, Kang S. Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis. Oncogene. 2017;36(27):3797–3806. PMCID: PMC5501759
    Reference Link
  • 1.
    Rubinstein B, Mattingly H, Berezhkovskii A, Shvartsman S. Long-term dynamics of multisite phosphorylation. Mol Biol Cell. 2016;27(14):2331–40. PMCID: PMC4945148
    Reference Link
  • 1.
    Alesi G, Jin L, Li D, Magliocca K, Kang Y, Chen Z, Shin D, Khuri F, Kang S. RSK2 signals through stathmin to promote microtubule dynamics and tumor metastasis. Oncogene. 2016;35(41):5412–5421. PMCID: PMC5226067
    Reference Link
  • 1.
    Rowles D, Tsai Y-C, Greco T, Lin A, Li M, Yeh J, Cristea I. DNA methyltransferase DNMT3A associates with viral proteins and impacts HSV-1 infection. Proteomics. 2015;15(12):1968–82. PMCID: PMC4550099
    Reference Link
  • 1.
    Boyaci H, Shah T, Hurley A, Kokona B, Li Z, Ventocilla C, Jeffrey P, Semmelhack M, Fairman R, Bassler B, Hughson F. Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO. PLoS Biol. 2016;14(5):e1002464. PMCID: PMC4878744
    Reference Link
  • 1.
    Yang L, Paul S, Trieu K, Dent L, Froldi F, Forés M, Webster K, Siegfried K, Kondo S, Harvey K, Cheng L, Jiménez G, Shvartsman S, Veraksa A. Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua. Proc Natl Acad Sci U S A. 2016;113(38):10583–8. PMCID: PMC5035877
    Reference Link
  • 1.
    Frietze K, Pappy A, Melson J, O’Driscoll E, Tyler C, Perlman D, Boulanger L. Cryptic protein-protein interaction motifs in the cytoplasmic domain of MHCI proteins. BMC Immunol. 2016;17(1):24. PMCID: PMC4950430
    Reference Link
  • 1.
    Shrestha R, Little K, Tamayo J, Li W, Perlman D, Devenport D. Mitotic Control of Planar Cell Polarity by Polo-like Kinase 1. Dev Cell. 2015;33(5):522–34. PMCID: PMC4464975
    Reference Link
  • 1.
    DeHart C, Chahal J, Flint S, Perlman D. Extensive post-translational modification of active and inactivated forms of endogenous p53. Mol Cell Proteomics. 2014;13(1):1–17. PMCID: PMC3879606
    Reference Link
  • 1.
    Zhao P, Xu Y, Wei Y, Qiu Q, Chew T-L, Kang Y, Cheng C. The CD44s splice isoform is a central mediator for invadopodia activity. J Cell Sci. 2016;129(7):1355–65. PMCID: PMC6518308
    Reference Link
  • 1.
    Oberstein A, Perlman D, Shenk T, Terry L. Human cytomegalovirus pUL97 kinase induces global changes in the infected cell phosphoproteome. Proteomics. 2015;15(12):2006–22. PMCID: PMC4522931
    Reference Link
  • 1.
    Bassler B, Wright M, Silverman M. Multiple signalling systems controlling expression of luminescence in Vibrio harveyi: sequence and function of genes encoding a second sensory pathway. Mol Microbiol. 1994;13(2):273–86. PMID: 7984107
    Reference Link
  • 1.
    Taga M, Miller S, Bassler B. Lsr-mediated transport and processing of AI-2 in Salmonella typhimurium. Mol Microbiol. 2003;50(4):1411–27. PMID: 14622426
    Reference Link
  • 1.
    Xavier K, Miller S, Lu W, Kim J, Rabinowitz J, Pelczer I, Semmelhack M, Bassler B. Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria. ACS Chem Biol. 2007;2(2):128–36. PMID: 17274596
    Reference Link
  • 1.
    Wei Y, Ng W-L, Cong J, Bassler B. Ligand and antagonist driven regulation of the Vibrio cholerae quorum-sensing receptor CqsS. Mol Microbiol. 2012;83(6):1095–108. PMCID: PMC3310172
    Reference Link

Footer

Connect with Mol Bio

  • Facebook
  • Twitter

Department of Molecular Biology
119 Lewis Thomas Laboratory
Washington Road
Princeton, NJ 08544-1014
Need help? Contact us

Visitor Parking Information

Intranet Login

Privacy Notice

Explore

  • Graduate Program
  • Undergraduate Program
  • Summer Undergraduate Research Program (SURP)
  • Research Areas
  • Molecular Biology Faculty
  • Faculty Research Labs

Core Facilities & Instruments

  • Biophysics
  • Confocal Microscopy
  • Drosophila Media
  • Electron Microscopy
  • Flow Cytometry
  • Histology
  • Imaging Facility at LSI
  • Laboratory Animal Resources
  • Macromolecular Crystallography
  • Nikon Center of Excellence
  • Proteomics & Mass Spectrometry
  • Sequencing & Microarray
  • Synseq

Programs & Institutes

  • Graduate Program in Quantitative and Computational Biology
  • Glenn Laboratories For Aging Research
  • Lewis-Sigler Institute for Integrative Genomics
  • Princeton Neuroscience Institute
  • Diversity & Non-Discrimination
  • Accessibility Help

© 2025 The Trustees of Princeton University

Princeton University