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Phenotype

  • 1.
    von Holdt B, Kartzinel R, van Oers K, Verhoeven K, Ouyang J. Changes in the rearing environment cause reorganization of molecular networks associated with DNA methylation. J Anim Ecol. 2023;92(3):648–664. PMID: 36567635
    Reference Link
  • 1.
    Do T, Thokkadam A, Leach R, Link J. Phenotype-Guided Comparative Genomics Identifies the Complete Transport Pathway of the Antimicrobial Lasso Peptide Ubonodin in . ACS Chem Biol. 2022;17(8):2332–2343. PMCID: PMC9454059
    Reference Link
  • 1.
    Fauser F, Vilarrasa-Blasi J, Onishi M, Ramundo S, Patena W, Millican M, Osaki J, Philp C, Nemeth M, Salomé P, Li X, Wakao S, Kim R, Kaye Y, Grossman A, Niyogi K, Merchant S, Cutler S, Walter P, Dinneny J, Jonikas M, Jinkerson R. Systematic characterization of gene function in the photosynthetic alga Chlamydomonas reinhardtii. Nat Genet. 2022;54(5):705–714. PMCID: PMC9110296
    Reference Link
  • 1.
    Qin Y, Kernan K, Fan Z, Park H-J, Kim S, Canna S, Kellum J, Berg R, Wessel D, Pollack M, Meert K, Hall M, Newth C, Lin J, Doctor A, Shanley T, Cornell T, Harrison R, Zuppa A, Banks R, Reeder R, Holubkov R, Notterman D, Dean M, Carcillo J. Machine learning derivation of four computable 24-h pediatric sepsis phenotypes to facilitate enrollment in early personalized anti-inflammatory clinical trials. Crit Care. 2022;26(1):128. PMCID: PMC9077858
    Reference Link
  • 1.
    Klibaite U, Kislin M, Verpeut J, Bergeler S, Sun X, Shaevitz J, Wang S. Deep phenotyping reveals movement phenotypes in mouse neurodevelopmental models. Mol Autism. 2022;13(1):12. PMCID: PMC8917660
    Reference Link
  • 1.
    Kernan K, Ghaloul-Gonzalez L, Vockley J, Lamb J, Hollingshead D, Chandran U, Sethi R, Park H-J, Berg R, Wessel D, Pollack M, Meert K, Hall M, Newth C, Lin J, Doctor A, Shanley T, Cornell T, Harrison R, Zuppa A, Banks R, Reeder R, Holubkov R, Notterman D, Dean M, Carcillo J. Prevalence of Pathogenic and Potentially Pathogenic Inborn Error of Immunity Associated Variants in Children with Severe Sepsis. J Clin Immunol. 2022;42(2):350–364. PMCID: PMC8720168
    Reference Link
  • 1.
    Hussmann J, Ling J, Ravisankar P, Yan J, Cirincione A, Xu A, Simpson D, Yang D, Bothmer A, Cotta-Ramusino C, Weissman J, Adamson B. Mapping the genetic landscape of DNA double-strand break repair. Cell. 2021;184(22):5653–5669.e25. PMCID: PMC9074467
    Reference Link
  • 1.
    Quinn J, Jones M, Okimoto R, Nanjo S, Chan M, Yosef N, Bivona T, Weissman J. Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts. Science. 2021;371(6532). PMCID: PMC7983364
    Reference Link
  • 1.
    Wong A, Sealfon R, Theesfeld C, Troyanskaya O. Decoding disease: from genomes to networks to phenotypes. Nat Rev Genet. 2021;22(12):774–790. PMCID: 6786975
    Reference Link
  • 1.
    Chini C, Peclat T, Warner G, Kashyap S, Espindola-Netto J, de Oliveira G, Gomez L, Hogan K, Tarragó M, Puranik A, Agorrody G, Thompson K, Dang K, Clarke S, Childs B, Kanamori K, Witte M, Vidal P, Kirkland A, De Cecco M, Chellappa K, McReynolds M, Jankowski C, Tchkonia T, Kirkland J, Sedivy J, van Deursen J, Baker D, van Schooten W, Rabinowitz J, Baur J, Chini E. CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD and NMN levels. Nat Metab. 2020;2(11):1284–1304. PMCID: PMC8752031
    Reference Link
  • 1.
    Mor D, Sohrabi S, Kaletsky R, Keyes W, Tartici A, Kalia V, Miller G, Murphy C. Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria. Proc Natl Acad Sci U S A. 2020;117(42):26438–26447. PMCID: PMC7585014
    Reference Link
  • 1.
    Aiello-Couzo N, Kang Y. A bridge between melanoma cell states. Nat Cell Biol. 2020;22(8):913–914. PMID: 32753670
    Reference Link
  • 1.
    Garrison C, Singh-Varma A, Pastino A, Steele J, Kohn J, Murthy S, Schwarzbauer J. A multilayered scaffold for regeneration of smooth muscle and connective tissue layers. J Biomed Mater Res A. 2021;109(5):733–744. PMCID: PMC7855544
    Reference Link
  • 1.
    Kaletsky R, Murphy C. Transcriptional Profiling of C. elegans Adult Cells and Tissues with Age. Methods Mol Biol. 2020;2144:177–186. PMID: 32410035
    Reference Link
  • 1.
    Sealfon R, Mariani L, Kretzler M, Troyanskaya O. Machine learning, the kidney, and genotype-phenotype analysis. Kidney Int. 2020;97(6):1141–1149. PMCID: PMC8048707
    Reference Link
  • 1.
    Kyrchanova O, Maksimenko O, Ibragimov A, Sokolov V, Postika N, Lukyanova M, Schedl P, Georgiev P. The insulator functions of the polydactyl C2H2 zinc finger protein CTCF: Necessity versus sufficiency. Sci Adv. 2020;6(13):eaaz3152. PMCID: PMC7096168
    Reference Link
  • 1.
    Park J-D, Moon K, Miller C, Rose J, Xu F, Ebmeier C, Jacobsen J, Mao D, Old W, DeShazer D, Seyedsayamdost M. Thailandenes, Cryptic Polyene Natural Products Isolated from Using Phenotype-Guided Transposon Mutagenesis. ACS Chem Biol. 2020;15(5):1195–1203. PMCID: PMC9106368
    Reference Link
  • 1.
    Benson K, Hu W, Weller A, Bennett A, Chen E, Khetarpal S, Yoshino S, Bone W, Wang L, Rabinowitz J, Voight B, Soccio R. Natural human genetic variation determines basal and inducible expression of , an obesity-associated gene. Proc Natl Acad Sci U S A. 2019;116(46):23232–23242. PMCID: PMC6859347
    Reference Link
  • 1.
    Carcillo J, Berg R, Wessel D, Pollack M, Meert K, Hall M, Newth C, Lin J, Doctor A, Shanley T, Cornell T, Harrison R, Zuppa A, Reeder R, Banks R, Kellum J, Holubkov R, Notterman D, Dean M, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network. A Multicenter Network Assessment of Three Inflammation Phenotypes in Pediatric Sepsis-Induced Multiple Organ Failure. Pediatr Crit Care Med. 2019;20(12):1137–1146. PMCID: PMC8121153
    Reference Link
  • 1.
    Itakura A, Chan K, Atkinson N, Pallesen L, Wang L, Reeves G, Patena W, Caspari O, Roth R, Goodenough U, McCormick A, Griffiths H, Jonikas M. A Rubisco-binding protein is required for normal pyrenoid number and starch sheath morphology in . Proc Natl Acad Sci U S A. 2019;116(37):18445–18454. PMCID: PMC6744930
    Reference Link
  • 1.
    Tandon D, Ressler K, Petticord D, Papa A, Jiranek J, Wilkinson R, Kartzinel R, Ostrander E, Burney N, Borden C, Udell M, vonHoldt B. Homozygosity for Mobile Element Insertions Associated with Could Predict Success in Assistance Dog Training Programs. Genes (Basel). 2019;10(6). PMCID: PMC6627829
    Reference Link
  • 1.
    Chan M, Smith Z, Grosswendt S, Kretzmer H, Norman T, Adamson B, Jost M, Quinn J, Yang D, Jones M, Khodaverdian A, Yosef N, Meissner A, Weissman J. Molecular recording of mammalian embryogenesis. Nature. 2019;570(7759):77–82. PMCID: PMC7229772
    Reference Link
  • 1.
    Aedo S, Orman M, Brynildsen M. Stationary phase persister formation in Escherichia coli can be suppressed by piperacillin and PBP3 inhibition. BMC Microbiol. 2019;19(1):140. PMCID: PMC6591824
    Reference Link
  • 1.
    Zhou J, Park C, Theesfeld C, Wong A, Yuan Y, Scheckel C, Fak J, Funk J, Yao K, Tajima Y, Packer A, Darnell R, Troyanskaya O. Whole-genome deep-learning analysis identifies contribution of noncoding mutations to autism risk. Nat Genet. 2019;51(6):973–980. PMCID: PMC6758908
    Reference Link
  • 1.
    Aedo S, Ma H, Brynildsen M. Checks and Balances with Use of the Keio Collection for Phenotype Testing. Methods Mol Biol. 2019;1927:125–138. PMID: 30788789
    Reference Link
  • 1.
    vonHoldt B, Kartzinel R, Huber C, Le Underwood V, Zhen Y, Ruegg K, Lohmueller K, Smith T. Growth factor gene IGF1 is associated with bill size in the black-bellied seedcracker Pyrenestes ostrinus. Nat Commun. 2018;9(1):4855. PMCID: PMC6242981
    Reference Link
  • 1.
    Kaletsky R, Yao V, Williams A, Runnels A, Tadych A, Zhou S, Troyanskaya O, Murphy C. Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression. PLoS Genet. 2018;14(8):e1007559. PMCID: PMC6105014
    Reference Link
  • 1.
    FitzGerald G, Botstein D, Califf R, Collins R, Peters K, Van Bruggen N, Rader D. The future of humans as model organisms. Science. 2018;361(6402):552–553. PMID: 30093589
    Reference Link
  • 1.
    Celià-Terrassa T, Kang Y. Metastatic niche functions and therapeutic opportunities. Nat Cell Biol. 2018;20(8):868–877. PMCID: 4161226
    Reference Link
  • 1.
    Rosenthal G, Schumer M, Andolfatto P. How the manakin got its crown: A novel trait that is unlikely to cause speciation. Proc Natl Acad Sci U S A. 2018;115(18):E4144-E4145. PMCID: PMC5939116
    Reference Link
  • 1.
    Aebersold R, Agar J, Amster J, Baker M, Bertozzi C, Boja E, Costello C, Cravatt B, Fenselau C, Garcia B, Ge Y, Gunawardena J, Hendrickson R, Hergenrother P, Huber C, Ivanov A, Jensen O, Jewett M, Kelleher N, Kiessling L, Krogan N, Larsen M, Loo J, Loo R, Lundberg E, MacCoss M, Mallick P, Mootha V, Mrksich M, Muir T, Patrie S, Pesavento J, Pitteri S, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff S, Smith L, Snyder M, Thomas P, Uhlén M, Van Eyk J, Vidal M, Walt D, White F, Williams E, Wohlschlager T, Wysocki V, Yates N, Young N, Zhang B. How many human proteoforms are there?. Nat Chem Biol. 2018;14(3):206–214. PMCID: PMC5837046
    Reference Link
  • 1.
    Donnelly A, Murphy G, Digianantonio K, Hecht M. A de novo enzyme catalyzes a life-sustaining reaction in Escherichia coli. Nat Chem Biol. 2018;14(3):253–255. PMID: 29334382
    Reference Link
  • 1.
    Keenan S, Shvartsman S. Mechanisms and causality in molecular diseases. Hist Philos Life Sci. 2017;39(4):35. PMCID: PMC6445273
    Reference Link
  • 1.
    Pujol F, Hodgson T, Martinez-Corral I, Prats A-C, Devenport D, Takeichi M, Genot E, Mäkinen T, Francis-West P, Garmy-Susini B, Tatin F. Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report. Arterioscler Thromb Vasc Biol. 2017;37(9):1732–1735. PMID: 28705793
    Reference Link
  • 1.
    Celià-Terrassa T, Liu D, Choudhury A, Hang X, Wei Y, Zamalloa J, Alfaro-Aco R, Chakrabarti R, Jiang Y-Z, Koh B, Smith H, DeCoste C, Li J-J, Shao Z-M, Kang Y. Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axis. Nat Cell Biol. 2017;19(6):711–723. PMCID: PMC5481166
    Reference Link
  • 1.
    Duncan J, Stoller M, Francl A, Tissir F, Devenport D, Deans M. Celsr1 coordinates the planar polarity of vestibular hair cells during inner ear development. Dev Biol. 2017;423(2):126–137. PMCID: PMC5369242
    Reference Link
  • 1.
    Anllo L, Schüpbach T. Signaling through the G-protein-coupled receptor Rickets is important for polarity, detachment, and migration of the border cells in Drosophila. Dev Biol. 2016;414(2):193–206. PMCID: PMC4887387
    Reference Link
  • 1.
    Kyrchanova O, Mogila V, Wolle D, Deshpande G, Parshikov A, Cleard F, Karch F, Schedl P, Georgiev P. Functional Dissection of the Blocking and Bypass Activities of the Fab-8 Boundary in the Drosophila Bithorax Complex. PLoS Genet. 2016;12(7):e1006188. PMCID: PMC4948906
    Reference Link
  • 1.
    Goyal Y, Jindal G, Pelliccia J, Yamaya K, Yeung E, Futran A, Burdine R, Schüpbach T, Shvartsman S. Divergent effects of intrinsically active MEK variants on developmental Ras signaling. Nat Genet. 2017;49(3):465–469. PMCID: PMC5621734
    Reference Link
  • 1.
    Ding Q, von Schaewen M, Hrebikova G, Heller B, Sandmann L, Plaas M, Ploss A. Mice Expressing Minimally Humanized CD81 and Occludin Genes Support Hepatitis C Virus Uptake In Vivo. J Virol. 2017;91(4). PMCID: PMC5286898
    Reference Link
  • 1.
    Jindal G, Goyal Y, Yamaya K, Futran A, Kountouridis I, Balgobin C, Schüpbach T, Burdine R, Shvartsman S. In vivo severity ranking of Ras pathway mutations associated with developmental disorders. Proc Natl Acad Sci U S A. 2017;114(3):510–515. PMCID: PMC5255624
    Reference Link
  • 1.
    Bhogal B, Plaza-Jennings A, Gavis E. Nanos-mediated repression of hid protects larval sensory neurons after a global switch in sensitivity to apoptotic signals. Development. 2016;143(12):2147–59. PMCID: PMC4920170
    Reference Link
  • 1.
    Orman M, Brynildsen M. Inhibition of stationary phase respiration impairs persister formation in E. coli. Nat Commun. 2015;6:7983. PMCID: PMC4530465
    Reference Link
  • 1.
    Jonikas M, Collins S, Denic V, Oh E, Quan E, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman J, Schuldiner M. Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science. 2009;323(5922):1693–7. PMCID: PMC2877488
    Reference Link
  • 1.
    Li X, Zhang R, Patena W, Gang S, Blum S, Ivanova N, Yue R, Robertson J, Lefebvre P, Fitz-Gibbon S, Grossman A, Jonikas M. An Indexed, Mapped Mutant Library Enables Reverse Genetics Studies of Biological Processes in Chlamydomonas reinhardtii. Plant Cell. 2016;28(2):367–87. PMCID: PMC4790863
    Reference Link
  • 1.
    vonHoldt B, Pollinger J, Earl D, Knowles J, Boyko A, Parker H, Geffen E, Pilot M, Jedrzejewski W, Jedrzejewska B, Sidorovich V, Greco C, Randi E, Musiani M, Kays R, Bustamante C, Ostrander E, Novembre J, Wayne R. A genome-wide perspective on the evolutionary history of enigmatic wolf-like canids. Genome Res. 2011;21(8):1294–305. PMCID: PMC3149496
    Reference Link
  • 1.
    Verhoeven K, vonHoldt B, Sork V. Epigenetics in ecology and evolution: what we know and what we need to know. Mol Ecol. 2016;25(8):1631–8. PMID: 26994410
    Reference Link
  • 1.
    Chung N, Storey J. Statistical significance of variables driving systematic variation in high-dimensional data. Bioinformatics. 2015;31(4):545–54. PMCID: PMC4325543
    Reference Link
  • 1.
    Seyedsayamdost M, Traxler M, Zheng S-L, Kolter R, Clardy J. Structure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4. J Am Chem Soc. 2011;133(30):11434–7. PMCID: PMC3144690
    Reference Link
  • 1.
    Wagner E, Stolfi A, Choi Y, Levine M. Islet is a key determinant of ascidian palp morphogenesis. Development. 2014;141(15):3084–92. PMCID: PMC4197658
    Reference Link

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