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Optogenetics

  • 1.
    Wegner S, Barocio-Galindo R, Avalos J. The bright frontiers of microbial metabolic optogenetics. Curr Opin Chem Biol. 2022;71:102207. PMID: 36103753
    Reference Link
  • 1.
    Singh A, Wu P, Ryabichko S, Raimundo J, Swan M, Wieschaus E, Gregor T, Toettcher J. Optogenetic control of the Bicoid morphogen reveals fast and slow modes of gap gene regulation. Cell Rep. 2022;38(12):110543. PMCID: PMC9019726
    Reference Link
  • 1.
    Hoffman S, Tang A, Avalos J. Optogenetics Illuminates Applications in Microbial Engineering. Annu Rev Chem Biomol Eng. 2022;13:373–403. PMID: 35320696
    Reference Link
  • 1.
    Broussard G, Kislin M, Jung C, Wang S. A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning. J Vis Exp. 2022;(179). PMCID: PMC9118201
    Reference Link
  • 1.
    Jack A, Kim Y, Strom A, Lee D, Williams B, Schaub J, Kellogg E, Finkelstein I, Ferro L, Yildiz A, Brangwynne C. Compartmentalization of telomeres through DNA-scaffolded phase separation. Dev Cell. 2022;57(2):277–290.e9. PMCID: PMC8988007
    Reference Link
  • 1.
    Lalwani M, Kawabe H, Mays R, Hoffman S, Avalos J. Optogenetic Control of Microbial Consortia Populations for Chemical Production. ACS Synth Biol. 2021;10(8):2015–2029. PMID: 34351122
    Reference Link
  • 1.
    Lalwani M, Zhao E, Wegner S, Avalos J. The Inducible Q System Enables Simultaneous Optogenetic Amplification and Inversion in for Bidirectional Control of Gene Expression. ACS Synth Biol. 2021;10(8):2060–2075. PMID: 34346207
    Reference Link
  • 1.
    Dine E, Reed E, Toettcher J. Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch. Cell Rep. 2021;35(12):109280. PMCID: PMC8292983
    Reference Link
  • 1.
    Zhao E, Lalwani M, Chen J-M, Orillac P, Toettcher J, Avalos J. Optogenetic Amplification Circuits for Light-Induced Metabolic Control. ACS Synth Biol. 2021;10(5):1143–1154. PMCID: PMC8721662
    Reference Link
  • 1.
    Farahani P, Reed E, Underhill E, Aoki K, Toettcher J. Signaling, Deconstructed: Using Optogenetics to Dissect and Direct Information Flow in Biological Systems. Annu Rev Biomed Eng. 2021;23:61–87. PMID: 33722063
    Reference Link
  • 1.
    Lovelett R, Zhao E, Lalwani M, Toettcher J, Kevrekidis I, Avalos J. Dynamical Modeling of Optogenetic Circuits in Yeast for Metabolic Engineering Applications. ACS Synth Biol. 2021;10(2):219–227. PMID: 33492138
    Reference Link
  • 1.
    Zhao E, Lalwani M, Lovelett R, García-Echauri S, Hoffman S, Gonzalez C, Toettcher J, Kevrekidis I, Avalos J. Design and Characterization of Rapid Optogenetic Circuits for Dynamic Control in Yeast Metabolic Engineering. ACS Synth Biol. 2020;9(12):3254–3266. PMID: 33232598
    Reference Link
  • 1.
    Carrasco-López C, García-Echauri S, Kichuk T, Avalos J. Optogenetics and biosensors set the stage for metabolic cybergenetics. Curr Opin Biotechnol. 2020;65:296–309. PMID: 32932048
    Reference Link
  • 1.
    Lalwani M, Ip S, Carrasco-López C, Day C, Zhao E, Kawabe H, Avalos J. Optogenetic control of the lac operon for bacterial chemical and protein production. Nat Chem Biol. 2021;17(1):71–79. PMCID: 5876151
    Reference Link
  • 1.
    Carrasco-López C, Zhao E, Gil A, Alam N, Toettcher J, Avalos J. Development of light-responsive protein binding in the monobody non-immunoglobulin scaffold. Nat Commun. 2020;11(1):4045. PMCID: PMC7427095
    Reference Link
  • 1.
    Gil A, Carrasco-López C, Zhu L, Zhao E, Ravindran P, Wilson M, Goglia A, Avalos J, Toettcher J. Optogenetic control of protein binding using light-switchable nanobodies. Nat Commun. 2020;11(1):4044. PMCID: PMC7426870
    Reference Link
  • 1.
    Kichuk T, Carrasco-López C, Avalos J. Lights up on organelles: Optogenetic tools to control subcellular structure and organization. WIREs Mech Dis. 2021;13(1):e1500. PMID: 32715616
    Reference Link
  • 1.
    Johnson H, Djabrayan N, Shvartsman S, Toettcher J. Optogenetic Rescue of a Patterning Mutant. Curr Biol. 2020;30(17):3414–3424.e3. PMCID: PMC7730203
    Reference Link
  • 1.
    Goglia A, Wilson M, Jena S, Silbert J, Basta L, Devenport D, Toettcher J. A Live-Cell Screen for Altered Erk Dynamics Reveals Principles of Proliferative Control. Cell Syst. 2020;10(3):240–253.e6. PMCID: PMC7540725
    Reference Link
  • 1.
    Deverett B, Kislin M, Tank D, Wang S. Cerebellar disruption impairs working memory during evidence accumulation. Nat Commun. 2019;10(1):3128. PMCID: PMC6635393
    Reference Link
  • 1.
    Patel A, Yeung E, McGuire S, Wu A, Toettcher J, Burdine R, Shvartsman S. Optimizing photoswitchable MEK. Proc Natl Acad Sci U S A. 2019;116(51):25756–25763. PMCID: PMC6926043
    Reference Link
  • 1.
    Zhu L, Richardson T, Wacheul L, Wei M-T, Feric M, Whitney G, Lafontaine D, Brangwynne C. Controlling the material properties and rRNA processing function of the nucleolus using light. Proc Natl Acad Sci U S A. 2019;116(35):17330–17335. PMCID: PMC6717270
    Reference Link
  • 1.
    Zhao E, Suek N, Wilson M, Dine E, Pannucci N, Gitai Z, Avalos J, Toettcher J. Light-based control of metabolic flux through assembly of synthetic organelles. Nat Chem Biol. 2019;15(6):589–597. PMCID: PMC6755918
    Reference Link
  • 1.
    Goglia A, Toettcher J. A bright future: optogenetics to dissect the spatiotemporal control of cell behavior. Curr Opin Chem Biol. 2019;48:106–113. PMCID: PMC6382565
    Reference Link
  • 1.
    Allard C, Decker F, Weiner O, Toettcher J, Graziano B. A size-invariant bud-duration timer enables robustness in yeast cell size control. PLoS One. 2018;13(12):e0209301. PMCID: PMC6303054
    Reference Link
  • 1.
    Liu M, Sharma A, Shaevitz J, Leifer A. Temporal processing and context dependency in response to mechanosensation. Elife. 2018;7. PMCID: PMC6054533
    Reference Link
  • 1.
    Yartsev M, Hanks T, Yoon A, Brody C. Causal contribution and dynamical encoding in the striatum during evidence accumulation. Elife. 2018;7. PMCID: PMC6147735
    Reference Link
  • 1.
    Cande J, Namiki S, Qiu J, Korff W, Card G, Shaevitz J, Stern D, Berman G. Optogenetic dissection of descending behavioral control in . Elife. 2018;7. PMCID: PMC6031430
    Reference Link
  • 1.
    Dine E, Gil A, Uribe G, Brangwynne C, Toettcher J. Protein Phase Separation Provides Long-Term Memory of Transient Spatial Stimuli. Cell Syst. 2018;6(6):655–663.e5. PMCID: PMC6023754
    Reference Link
  • 1.
    Johnson H, Toettcher J. Illuminating developmental biology with cellular optogenetics. Curr Opin Biotechnol. 2018;52:42–48. PMCID: PMC6082700
    Reference Link
  • 1.
    Zhao E, Zhang Y, Mehl J, Park H, Lalwani M, Toettcher J, Avalos J. Optogenetic regulation of engineered cellular metabolism for microbial chemical production. Nature. 2018;555(7698):683–687. PMCID: PMC5876151
    Reference Link
  • 1.
    Akrami A, Kopec C, Diamond M, Brody C. Posterior parietal cortex represents sensory history and mediates its effects on behaviour. Nature. 2018;554(7692):368–372. PMID: 29414944
    Reference Link
  • 1.
    Dine E, Toettcher J. Optogenetic Reconstitution for Determining the Form and Function of Membraneless Organelles. Biochemistry. 2018;57(17):2432–2436. PMCID: PMC5972035
    Reference Link
  • 1.
    Wilson M, Ravindran P, Lim W, Toettcher J. Tracing Information Flow from Erk to Target Gene Induction Reveals Mechanisms of Dynamic and Combinatorial Control. Mol Cell. 2017;67(5):757–769.e5. PMCID: PMC5591080
    Reference Link
  • 1.
    Goglia A, Wilson M, DiGiorno D, Toettcher J. Optogenetic Control of Ras/Erk Signaling Using the Phy-PIF System. Methods Mol Biol. 2017;1636:3–20. PMID: 28730469
    Reference Link
  • 1.
    Johnson H, Goyal Y, Pannucci N, Schüpbach T, Shvartsman S, Toettcher J. The Spatiotemporal Limits of Developmental Erk Signaling. Dev Cell. 2017;40(2):185–192. PMCID: PMC5289754
    Reference Link
  • 1.
    Shin Y, Berry J, Pannucci N, Haataja M, Toettcher J, Brangwynne C. Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets. Cell. 2017;168(1-2):159–171.e14. PMCID: PMC5562165
    Reference Link
  • 1.
    Johnson H, Toettcher J. The Duty of an Intracellular Signal: Illuminating Calcium’s Role in Transcriptional Control. Cell Syst. 2016;2(4):223–4. PMID: 27135534
    Reference Link
  • 1.
    Rickgauer J, Deisseroth K, Tank D. Simultaneous cellular-resolution optical perturbation and imaging of place cell firing fields. Nat Neurosci. 2014;17(12):1816–24. PMCID: PMC4459599
    Reference Link
  • 1.
    Toettcher J, Weiner O, Lim W. Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell. 2013;155(6):1422–34. PMCID: PMC3925772
    Reference Link

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