Department of Molecular Biology

Off screen link: Skip to content Off screen link: Skip to search
Princeton University
Home

Main Menu

  • Department
    Department
    • Chair’s Welcome
    • Administration & Staff
    • Associated Programs, Institutes & Departments
    • Grants Submission Policy & Funding Opportunities
    • Open Positions
    • MolBio Retreat 2024
      • MolBio Retreat 2024 Schedule
  • Faculty & Research
    Faculty & Research
    • Faculty
    • Research Areas
      • Biochemistry, Biophysics & Structural Biology
      • Cell Biology, Development & Cancer
      • Genetics & Genomics
      • Microbiology, Virology & Immunology
      • Quantitative & Computational Biology
  • Postdoc
    Postdoc
    • Overview
    • Prospective Postdoc
    • New Postdoc
    • Postdoc Community
    • Career Development
    • Lewis-Sigler Fellows
    • Contacts
  • Graduate
    Graduate
    • Overview
    • Admission & Financial Support
    • Requirements
    • Courses
    • MD/PhD Program
    • MolBio Scholars
    • Outreach Program
    • Faculty Graduate Committee
    • Department Life
      • Life in the Department
      • Graduate Student Committees
      • Career Resources
      • Student Life
      • Incoming Graduate Students
    • Molecular Biology Training Grants
  • Undergraduate
    Undergraduate
    • Overview
    • Teaching Mission
    • Major
      • Major Requirements
      • Departmentals
      • Declare a Major
      • Typical Paths
      • Courses
      • Minor & Certificate Programs
      • Study Abroad
      • Junior Independent Work
      • Senior Thesis
    • Research
      • Current Lab Assignments
      • Summer Research
      • Sophomore Research Course
      • Internship Milestone Credit
      • Undergraduate Publications
    • Career Resources
    • Community
      • Undergraduate Community
      • Important Dates and Deadlines
      • Class Day
    • Contacts
  • Core Facilities
    Core Facilities
    • Overview
    • Shared Imaging Facilities
      • Confocal Microscopy
        • Instruments
        • Fluorescent Dyes
        • ILab Calendar and Service Requests
        • User Training
        • Nikon Center of Excellence
        • Contact
      • Electron Microscopy
        • Equipment
        • Pricing
        • Contacts
      • Imaging & Analysis Center
      • Nikon Center of Excellence
    • Shared Research Facilities
      • Biophysics
      • Drosophila Media
      • Flow Cytometry
        • Facility Use
        • Instruments
        • ILab Calendar and Service Requests
        • Contact
      • Genome Editing Shared Resource (Rutgers-CINJ)
      • Histology
      • Lab Animal Resources
      • Macromolecular Crystallography
      • NMR Facility
      • Proteomics & Mass Spec
        • Proteomics & MS Services
        • Protocols & Guidelines
      • Research Computing
      • Sequencing & Microarray
      • Synseq
    • Other Facilities
      • IT Support
      • Facilities & Maintenance
      • Environmental Health & Safety (EHS)
  • Community
    Community
    • DEI Committee
    • Code of Conduct
  • Apply & Visit
  • Contact
  • People
  • Donors
  • News
  • Events
    • Events Archive

Search

Neoplasms

  • 1.
    Chen Z, Kang Y. Cold snap for cancer: cold-induced brown fat thermogenesis starves tumor growth. Signal Transduct Target Ther. 2023;8(1):10. PMCID: PMC9826784
    Reference Link
  • 1.
    Zhao H, Teng D, Yang L, Xu X, Chen J, Jiang T, Feng A, Zhang Y, Frederick D, Gu L, Cai L, Asara J, di Magliano M, Boland G, Flaherty K, Swanson K, Liu D, Rabinowitz J, Zheng B. Myeloid-derived itaconate suppresses cytotoxic CD8 T cells and promotes tumour growth. Nat Metab. 2022;4(12):1660–1673. PMID: 36376563
    Reference Link
  • 1.
    Shen M, Kang Y. Cancer fitness genes: emerging therapeutic targets for metastasis. Trends Cancer. 2023;9(1):69–82. PMID: 36184492
    Reference Link
  • 1.
    Mitchener M, Muir T. Oncohistones: Exposing the nuances and vulnerabilities of epigenetic regulation. Mol Cell. 2022;82(16):2925–2938. PMCID: PMC9482148
    Reference Link
  • 1.
    Lim A, Verrier T, Vosshenrich C, Di Santo J. Developmental options and functional plasticity of innate lymphoid cells. Curr Opin Immunol. 2017;44:61–68. PMID: 28359987
    Reference Link
  • 1.
    Yang D, Jones M, Naranjo S, Rideout W, Min K, Ho R, Wu W, Replogle J, Page J, Quinn J, Horns F, Qiu X, Chen M, Freed-Pastor W, McGinnis C, Patterson D, Gartner Z, Chow E, Bivona T, Chan M, Yosef N, Jacks T, Weissman J. Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution. Cell. 2022;185(11):1905–1923.e25. PMCID: PMC9452598
    Reference Link
  • 1.
    LaChance J, Suh K, Clausen J, Cohen D. Learning the rules of collective cell migration using deep attention networks. PLoS Comput Biol. 2022;18(4):e1009293. PMCID: PMC9106212
    Reference Link
  • 1.
    Wyer S, Townsend D, Ye Z, Kourtidis A, Choo Y-M, de Barros A, Donia M, Hamann M. Recent advances and limitations in the application of kahalalides for the control of cancer. Biomed Pharmacother. 2022;148:112676. PMCID: PMC9004612
    Reference Link
  • 1.
    Fang C, Kang Y. E-Cadherin: Context-Dependent Functions of a Quintessential Epithelial Marker in Metastasis. Cancer Res. 2021;81(23):5800–5802. PMID: 34853039
    Reference Link
  • 1.
    Ghergurovich J, Xu X, Wang J, Yang L, Ryseck R-P, Wang L, Rabinowitz J. Methionine synthase supports tumour tetrahydrofolate pools. Nat Metab. 2021;3(11):1512–1520. PMCID: PMC9284419
    Reference Link
  • 1.
    Olszewski K, Barsotti A, Feng X-J, Momcilovic M, Liu K, Kim J-I, Morris K, Lamarque C, Gaffney J, Yu X, Patel J, Rabinowitz J, Shackelford D, Poyurovsky M. Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors. Cell Chem Biol. 2022;29(3):423–435.e10. PMID: 34715056
    Reference Link
  • 1.
    Poillet-Perez L, Sharp D, Yang Y, Laddha S, Ibrahim M, Bommareddy P, Hu Z, Vieth J, Haas M, Bosenberg M, Rabinowitz J, Cao J, Guan J-L, Ganesan S, Chan C, Mehnert J, Lattime E, White E. Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response. Nat Cancer. 2020;1(9):923–934. PMCID: PMC8409526
    Reference Link
  • 1.
    Cable J, Pourquié O, Wellen K, Finley L, Aulehla A, Gould A, Teleman A, Tu W, Garrett W, Miguel-Aliaga I, Perrimon N, Hooper L, Walhout A, Wei W, Alexandrov T, Erez A, Ralser M, Rabinowitz J, Hemalatha A, Gutiérrez-Pérez P, Chandel N, Rutter J, Locasale J, Landoni J, Christofk H. Metabolic decisions in development and disease-a Keystone Symposia report. Ann N Y Acad Sci. 2021;1506(1):55–73. PMID: 34414571
    Reference Link
  • 1.
    Baumeister R, Murphy C, Heimbucher T. Metabolic adaptation to hypoxia: do worms and cancer cells share common metabolic responses to hypoxic stress?. Cell Death Differ. 2021;28(4):1434–1436. PMCID: PMC8026991
    Reference Link
  • 1.
    Esposito M, Ganesan S, Kang Y. Emerging strategies for treating metastasis. Nat Cancer. 2021;2(3):258–270. PMCID: PMC8064405
    Reference Link
  • 1.
    Bagert J, Mitchener M, Patriotis A, Dul B, Wojcik F, Nacev B, Feng L, Allis D, Muir T. Oncohistone mutations enhance chromatin remodeling and alter cell fates. Nat Chem Biol. 2021;17(4):403–411. PMCID: PMC8174649
    Reference Link
  • 1.
    Shen M, Kang Y. Stresses in the metastatic cascade: molecular mechanisms and therapeutic opportunities. Genes Dev. 2020;34(23-24):1577–1598. PMCID: PMC7706714
    Reference Link
  • 1.
    Ringel A, Drijvers J, Baker G, Catozzi A, García-Cañaveras J, Gassaway B, Miller B, Juneja V, Nguyen T, Joshi S, Yao C-H, Yoon H, Sage P, LaFleur M, Trombley J, Jacobson C, Maliga Z, Gygi S, Sorger P, Rabinowitz J, Sharpe A, Haigis M. Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell. 2020;183(7):1848–1866.e26. PMCID: PMC8064125
    Reference Link
  • 1.
    Lafontaine D, Riback J, Bascetin R, Brangwynne C. The nucleolus as a multiphase liquid condensate. Nat Rev Mol Cell Biol. 2021;22(3):165–182. PMCID: 147800
    Reference Link
  • 1.
    Hoshino A, Kim H, Bojmar L, Gyan K, Cioffi M, Hernandez J, Zambirinis C, Rodrigues G, Molina H, Heissel S, Mark M, Steiner L, Benito-Martin A, Lucotti S, Di Giannatale A, Offer K, Nakajima M, Williams C, Nogués L, Vatter F, Hashimoto A, Davies A, Freitas D, Kenific C, Ararso Y, Buehring W, Lauritzen P, Ogitani Y, Sugiura K, Takahashi N, Alečković M, Bailey K, Jolissant J, Wang H, Harris A, Schaeffer M, García-Santos G, Posner Z, Balachandran V, Khakoo Y, Raju P, Scherz A, Sagi I, Scherz-Shouval R, Yarden Y, Oren M, Malladi M, Petriccione M, De Braganca K, Donzelli M, Fischer C, Vitolano S, Wright G, Ganshaw L, Marrano M, Ahmed A, DeStefano J, Danzer E, Roehrl M, Lacayo N, Vincent T, Weiser M, Brady M, Meyers P, Wexler L, Ambati S, Chou A, Slotkin E, Modak S, Roberts S, Basu E, Diolaiti D, Krantz B, Cardoso F, Simpson A, Berger M, Rudin C, Simeone D, Jain M, Ghajar C, Batra S, Stanger B, Bui J, Brown K, Rajasekhar V, Healey J, de Sousa M, Kramer K, Sheth S, Baisch J, Pascual V, Heaton T, La Quaglia M, Pisapia D, Schwartz R, Zhang H, Liu Y, Shukla A, Blavier L, DeClerck Y, LaBarge M, Bissell M, Caffrey T, Grandgenett P, Hollingsworth M, Bromberg J, Costa-Silva B, Peinado H, Kang Y, Garcia B, O’Reilly E, Kelsen D, Trippett T, Jones D, Matei I, Jarnagin W, Lyden D. Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. Cell. 2020;182(4):1044–1061.e18. PMCID: PMC7522766
    Reference Link
  • 1.
    Kobren S, Chazelle B, Singh M. PertInInt: An Integrative, Analytical Approach to Rapidly Uncover Cancer Driver Genes with Perturbed Interactions and Functionalities. Cell Syst. 2020;11(1):63–74.e7. PMCID: PMC7493809
    Reference Link
  • 1.
    Betsinger C, Cristea I. Mitochondrial Function, Metabolic Regulation, and Human Disease Viewed through the Prism of Sirtuin 4 (SIRT4) Functions. J Proteome Res. 2019;18(5):1929–1938. PMCID: PMC6889813
    Reference Link
  • 1.
    Burton A, Haugbro M, Gates L, Bagert J, Allis D, Muir T. In situ chromatin interactomics using a chemical bait and trap approach. Nat Chem. 2020;12(6):520–527. PMCID: PMC7331920
    Reference Link
  • 1.
    Yang J, Antin P, Berx G, Blanpain C, Brabletz T, Bronner M, Campbell K, Cano A, Casanova J, Christofori G, Dedhar S, Derynck R, Ford H, Fuxe J, de Herreros A, Goodall G, Hadjantonakis A-K, Huang R, Kalcheim C, Kalluri R, Kang Y, Khew-Goodall Y, Levine H, Liu J, Longmore G, Mani S, Massagué J, Mayor R, McClay D, Mostov K, Newgreen D, Nieto A, Puisieux A, Runyan R, Savagner P, Stanger B, Stemmler M, Takahashi Y, Takeichi M, Theveneau E, Thiery J, Thompson E, Weinberg R, Williams E, Xing J, Zhou B, Sheng G, EMT International Association (TEMTIA). Guidelines and definitions for research on epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2020;21(6):341–352. PMCID: PMC7250738
    Reference Link
  • 1.
    García-Cañaveras J, Chen L, Rabinowitz J. The Tumor Metabolic Microenvironment: Lessons from Lactate. Cancer Res. 2019;79(13):3155–3162. PMCID: PMC6606343
    Reference Link
  • 1.
    Lu W, Kang Y. Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis. Dev Cell. 2019;49(3):361–374. PMCID: PMC6506183
    Reference Link
  • 1.
    Brown A, Chua N, Yan N. The shape of human squalene epoxidase expands the arsenal against cancer. Nat Commun. 2019;10(1):888. PMCID: PMC6384927
    Reference Link
  • 1.
    Nacev B, Feng L, Bagert J, Lemiesz A, Gao J, Soshnev A, Kundra R, Schultz N, Muir T, Allis D. The expanding landscape of ’oncohistone’ mutations in human cancers. Nature. 2019;567(7749):473–478. PMCID: PMC6512987
    Reference Link
  • 1.
    Aiello N, Kang Y. Context-dependent EMT programs in cancer metastasis. J Exp Med. 2019;216(5):1016–1026. PMCID: PMC6504222
    Reference Link
  • 1.
    Esposito M, Mondal N, Greco T, Wei Y, Spadazzi C, Lin S-C, Zheng H, Cheung C, Magnani J, Lin S-H, Cristea I, Sackstein R, Kang Y. Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis. Nat Cell Biol. 2019;21(5):627–639. PMCID: PMC6556210
    Reference Link
  • 1.
    Poillet-Perez L, Xie X, Zhan L, Yang Y, Sharp D, Hu Z, Su X, Maganti A, Jiang C, Lu W, Zheng H, Bosenberg M, Mehnert J, Guo J, Lattime E, Rabinowitz J, White E. Autophagy maintains tumour growth through circulating arginine. Nature. 2018;563(7732):569–573. PMCID: PMC6287937
    Reference Link
  • 1.
    Simi A, Pang M-F, Nelson C. Extracellular Matrix Stiffness Exists in a Feedback Loop that Drives Tumor Progression. Adv Exp Med Biol. 2018;1092:57–67. PMID: 30368748
    Reference Link
  • 1.
    Shen M, Kang Y. Complex interplay between tumor microenvironment and cancer therapy. Front Med. 2018;12(4):426–439. PMID: 30097962
    Reference Link
  • 1.
    Munro D, Ghersi D, Singh M. Two critical positions in zinc finger domains are heavily mutated in three human cancer types. PLoS Comput Biol. 2018;14(6):e1006290. PMCID: PMC6040777
    Reference Link
  • 1.
    Tanner L, Goglia A, Wei M, Sehgal T, Parsons L, Park J, White E, Toettcher J, Rabinowitz J. Four Key Steps Control Glycolytic Flux in Mammalian Cells. Cell Syst. 2018;7(1):49–62.e8. PMCID: PMC6062487
    Reference Link
  • 1.
    Celià-Terrassa T, Kang Y. Metastatic niche functions and therapeutic opportunities. Nat Cell Biol. 2018;20(8):868–877. PMCID: 4161226
    Reference Link
  • 1.
    Fernández-Capetillo Óscar, Yan N, Dionne J, Bassett D, Sebastian S, Hendon C, Schlichting H, Baker M. Hopes for the year ahead. Nature. 2015;517(7532):111–3. PMID: 25568916
    Reference Link
  • 1.
    Jindal G, Goyal Y, Humphreys J, Yeung E, Tian K, Patterson V, He H, Burdine R, Goldsmith E, Shvartsman S. How activating mutations affect MEK1 regulation and function. J Biol Chem. 2017;292(46):18814–18820. PMCID: PMC5704466
    Reference Link
  • 1.
    Hristov B, Singh M. Network-Based Coverage of Mutational Profiles Reveals Cancer Genes. Cell Syst. 2017;5(3):221–229.e4. PMCID: PMC5997485
    Reference Link
  • 1.
    Przytycki P, Singh M. Differential analysis between somatic mutation and germline variation profiles reveals cancer-related genes. Genome Med. 2017;9(1):79. PMCID: PMC5574113
    Reference Link
  • 1.
    Peinado H, Zhang H, Matei I, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan R, Bromberg J, Kang Y, Bissell M, Cox T, Giaccia A, Erler J, Hiratsuka S, Ghajar C, Lyden D. Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer. 2017;17(5):302–317. PMID: 28303905
    Reference Link
  • 1.
    Celià-Terrassa T, Kang Y. Mouse genomic screen reveals novel host regulator of metastasis. Genome Biol. 2017;18(1):31. PMCID: PMC5314612
    Reference Link
  • 1.
    Li Z, Kang Y. Lipid Metabolism Fuels Cancer’s Spread. Cell Metab. 2017;25(2):228–230. PMID: 28178563
    Reference Link
  • 1.
    Rabinowitz J, Coller H. Partners in the Warburg effect. Elife. 2016;5:e15938. PMCID: PMC4841767
    Reference Link
  • 1.
    Kang Y. Imaging TGFβ Signaling in Mouse Models of Cancer Metastasis. Methods Mol Biol. 2016;1344:219–32. PMID: 26520127
    Reference Link
  • 1.
    Ren G, Esposito M, Kang Y. Bone metastasis and the metastatic niche. J Mol Med (Berl). 2015;93(11):1203–12. PMCID: PMC4636917
    Reference Link
  • 1.
    Celià-Terrassa T, Kang Y. Distinctive properties of metastasis-initiating cells. Genes Dev. 2016;30(8):892–908. PMCID: PMC4840296
    Reference Link
  • 1.
    Goyal Y, Jindal G, Pelliccia J, Yamaya K, Yeung E, Futran A, Burdine R, Schüpbach T, Shvartsman S. Divergent effects of intrinsically active MEK variants on developmental Ras signaling. Nat Genet. 2017;49(3):465–469. PMCID: PMC5621734
    Reference Link
  • 1.
    Yang L, Paul S, Trieu K, Dent L, Froldi F, Forés M, Webster K, Siegfried K, Kondo S, Harvey K, Cheng L, Jiménez G, Shvartsman S, Veraksa A. Minibrain and Wings apart control organ growth and tissue patterning through down-regulation of Capicua. Proc Natl Acad Sci U S A. 2016;113(38):10583–8. PMCID: PMC5035877
    Reference Link
  • 1.
    Ducker G, Rabinowitz J. One-Carbon Metabolism in Health and Disease. Cell Metab. 2017;25(1):27–42. PMCID: PMC5353360
    Reference Link

Pagination

  • Page 1
  • Next page ››

Footer

Connect with Mol Bio

  • Facebook
  • Twitter

Department of Molecular Biology
119 Lewis Thomas Laboratory
Washington Road
Princeton, NJ 08544-1014
Need help? Contact us

Visitor Parking Information

Intranet Login

Privacy Notice

Explore

  • Graduate Program
  • Undergraduate Program
  • Summer Undergraduate Research Program (SURP)
  • Research Areas
  • Molecular Biology Faculty
  • Faculty Research Labs

Core Facilities & Instruments

  • Biophysics
  • Confocal Microscopy
  • Drosophila Media
  • Electron Microscopy
  • Flow Cytometry
  • Histology
  • Imaging Facility at LSI
  • Laboratory Animal Resources
  • Macromolecular Crystallography
  • Nikon Center of Excellence
  • Proteomics & Mass Spectrometry
  • Sequencing & Microarray
  • Synseq

Programs & Institutes

  • Graduate Program in Quantitative and Computational Biology
  • Glenn Laboratories For Aging Research
  • Lewis-Sigler Institute for Integrative Genomics
  • Princeton Neuroscience Institute
  • Diversity & Non-Discrimination
  • Accessibility Help

© 2025 The Trustees of Princeton University

Princeton University