1.Clark K, Covington B, Seyedsayamdost M. Biosynthesis-guided discovery reveals enteropeptins as alternative sactipeptides containing N-methylornithine. Nat Chem. 2022;14(12):1390–1398. PMID: 36316408 Reference Link
1.Han E, Lee S, Hoshino S, Seyedsayamdost M. Targeted Discovery of Cryptic Metabolites with Antiproliferative Activity. ACS Chem Biol. 2022;17(11):3121–3130. PMID: 36228140 Reference Link
1.Kayrouz C, Huang J, Hauser N, Seyedsayamdost M. Biosynthesis of selenium-containing small molecules in diverse microorganisms. Nature. 2022;610(7930):199–204. PMCID: 2881734 Reference Link
1.Li Y, Lee S, Han E, Seyedsayamdost M. Momomycin, an Antiproliferative Cryptic Metabolite from the Oxytetracycline Producer Streptomyces rimosus. Angew Chem Int Ed Engl. 2022;61(39):e202208573. PMCID: PMC9489664 Reference Link
1.Lee S, Seyedsayamdost M. Induction of Diverse Cryptic Fungal Metabolites by Steroids and Channel Blockers. Angew Chem Int Ed Engl. 2022;61(29):e202204519. PMCID: PMC9276648 Reference Link
1.Covington B, Seyedsayamdost M. Guidelines for metabolomics-guided transposon mutagenesis for microbial natural product discovery. Methods Enzymol. 2022;665:305–323. PMCID: PMC9078877 Reference Link
1.Matthews B, Dudchenko O, Kingan S, Koren S, Antoshechkin I, Crawford J, Glassford W, Herre M, Redmond S, Rose N, Weedall G, Wu Y, Batra S, Brito-Sierra C, Buckingham S, Campbell C, Chan S, Cox E, Evans B, Fansiri T, Filipović I, Fontaine A, Gloria-Soria A, Hall R, Joardar V, Jones A, Kay R, Kodali V, Lee J, Lycett G, Mitchell S, Muehling J, Murphy M, Omer A, Partridge F, Peluso P, Aiden A, Ramasamy V, Rašić G, Roy S, Saavedra-Rodriguez K, Sharan S, Sharma A, Smith M, Turner J, Weakley A, Zhao Z, Akbari O, Black W, Cao H, Darby A, Hill C, Johnston S, Murphy T, Raikhel A, Sattelle D, Sharakhov I, White B, Zhao L, Aiden E, Mann R, Lambrechts L, Powell J, Sharakhova M, Tu Z, Robertson H, McBride C, Hastie A, Korlach J, Neafsey D, Phillippy A, Vosshall L. Improved reference genome of Aedes aegypti informs arbovirus vector control. Nature. 2018;563(7732):501–507. PMCID: PMC6421076 Reference Link
1.Yoshimura A, Covington B, Gallant Étienne, Zhang C, Li A, Seyedsayamdost M. Unlocking Cryptic Metabolites with Mass Spectrometry-Guided Transposon Mutant Selection. ACS Chem Biol. 2020;15(10):2766–2774. PMCID: PMC7572862 Reference Link
1.Covington B, Xu F, Seyedsayamdost M. A Natural Product Chemist’s Guide to Unlocking Silent Biosynthetic Gene Clusters. Annu Rev Biochem. 2021;90:763–788. PMCID: PMC9148385 Reference Link
1.Kloosterman A, Cimermancic P, Elsayed S, Du C, Hadjithomas M, Donia M, Fischbach M, van Wezel G, Medema M. Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides. PLoS Biol. 2020;18(12):e3001026. PMCID: PMC7794033 Reference Link
1.Klaus J, Coulon P, Koirala P, Seyedsayamdost M, Déziel E, Chandler J. Secondary metabolites from the Burkholderia pseudomallei complex: structure, ecology, and evolution. J Ind Microbiol Biotechnol. 2020;47(9-10):877–887. PMCID: PMC7746414 Reference Link
1.Caruso A, Bushin L, Clark K, Martinie R, Seyedsayamdost M. Radical Approach to Enzymatic β-Thioether Bond Formation. J Am Chem Soc. 2019;141(2):990–997. PMID: 30521328 Reference Link
1.Cheung-Lee W, Cao L, Link J. Pandonodin: A Proteobacterial Lasso Peptide with an Exceptionally Long C-Terminal Tail. ACS Chem Biol. 2019;14(12):2783–2792. PMCID: PMC7010350 Reference Link
1.Li A, Mao D, Yoshimura A, Rosen P, Martin L, Gallant Étienne, Wühr M, Seyedsayamdost M. Multi-Omic Analyses Provide Links between Low-Dose Antibiotic Treatment and Induction of Secondary Metabolism in Burkholderia thailandensis. mBio. 2020;11(1). PMCID: PMC7042699 Reference Link
1.Greenberg P, Chandler J, Seyedsayamdost M. The Chemistry and Biology of Bactobolin: A 10-Year Collaboration with Natural Product Chemist Extraordinaire Jon Clardy. J Nat Prod. 2020;83(3):738–743. PMCID: PMC8118907 Reference Link
1.Mao D, Yoshimura A, Wang R, Seyedsayamdost M. Reporter-Guided Transposon Mutant Selection for Activation of Silent Gene Clusters in Burkholderia thailandensis. Chembiochem. 2020;21(13):1826–1831. PMCID: PMC7493819 Reference Link
1.Park J-D, Moon K, Miller C, Rose J, Xu F, Ebmeier C, Jacobsen J, Mao D, Old W, DeShazer D, Seyedsayamdost M. Thailandenes, Cryptic Polyene Natural Products Isolated from Using Phenotype-Guided Transposon Mutagenesis. ACS Chem Biol. 2020;15(5):1195–1203. PMCID: PMC9106368 Reference Link
1.Sugimoto Y, Camacho F, Wang S, Chankhamjon P, Odabas A, Biswas A, Jeffrey P, Donia M. A metagenomic strategy for harnessing the chemical repertoire of the human microbiome. Science. 2019;366(6471). PMID: 31582523 Reference Link
1.Bushin L, Clark K, Pelczer I, Seyedsayamdost M. Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif. J Am Chem Soc. 2018;140(50):17674–17684. PMID: 30398325 Reference Link
1.Cheung-Lee W, Link J. Genome mining for lasso peptides: past, present, and future. J Ind Microbiol Biotechnol. 2019;46(9-10):1371–1379. PMCID: PMC6989040 Reference Link
1.Xu F, Wu Y, Zhang C, Davis K, Moon K, Bushin L, Seyedsayamdost M. A genetics-free method for high-throughput discovery of cryptic microbial metabolites. Nat Chem Biol. 2019;15(2):161–168. PMCID: PMC6339573 Reference Link
1.Seyedsayamdost M. Toward a global picture of bacterial secondary metabolism. J Ind Microbiol Biotechnol. 2019;46(3-4):301–311. PMCID: PMC6779422 Reference Link
1.Tuttle R, Demko A, Patin N, Kapono C, Donia M, Dorrestein P, Jensen P. Detection of Natural Products and Their Producers in Ocean Sediments. Appl Environ Microbiol. 2019;85(8). PMCID: PMC6450032 Reference Link
1.Tianero M, Balaich J, Donia M. Localized production of defence chemicals by intracellular symbionts of Haliclona sponges. Nat Microbiol. 2019;4(7):1149–1159. PMCID: PMC8647704 Reference Link
1.Moon K, Xu F, Zhang C, Seyedsayamdost M. Bioactivity-HiTES Unveils Cryptic Antibiotics Encoded in Actinomycete Bacteria. ACS Chem Biol. 2019;14(4):767–774. PMCID: PMC6813803 Reference Link
1.Cheung-Lee W, Parry M, Cartagena A, Darst S, Link J. Discovery and structure of the antimicrobial lasso peptide citrocin. J Biol Chem. 2019;294(17):6822–6830. PMCID: PMC6497930 Reference Link
1.Bushin L, Seyedsayamdost M. Guidelines for Determining the Structures of Radical SAM Enzyme-Catalyzed Modifications in the Biosynthesis of RiPP Natural Products. Methods Enzymol. 2018;606:439–460. PMID: 30097102 Reference Link
1.McRose D, Baars O, Seyedsayamdost M, Morel F. Quorum sensing and iron regulate a two-for-one siderophore gene cluster in . Proc Natl Acad Sci U S A. 2018;115(29):7581–7586. PMCID: PMC6055174 Reference Link
1.Mao D, Bushin L, Moon K, Wu Y, Seyedsayamdost M. Discovery of as a global regulator of secondary metabolism and virulence in E264. Proc Natl Acad Sci U S A. 2017;114(14):E2920-E2928. PMCID: PMC5389298 Reference Link
1.Okada B, Seyedsayamdost M. Antibiotic dialogues: induction of silent biosynthetic gene clusters by exogenous small molecules. FEMS Microbiol Rev. 2017;41(1):19–33. PMCID: PMC5233716 Reference Link
1.Wang R, Gallant Étienne, Seyedsayamdost M. Investigation of the Genetics and Biochemistry of Roseobacticide Production in the Roseobacter Clade Bacterium Phaeobacter inhibens. mBio. 2016;7(2):e02118. PMCID: PMC4807370 Reference Link
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