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Multigene Family

  • 1.
    Clark K, Covington B, Seyedsayamdost M. Biosynthesis-guided discovery reveals enteropeptins as alternative sactipeptides containing N-methylornithine. Nat Chem. 2022;14(12):1390–1398. PMID: 36316408
    Reference Link
  • 1.
    Han E, Lee S, Hoshino S, Seyedsayamdost M. Targeted Discovery of Cryptic Metabolites with Antiproliferative Activity. ACS Chem Biol. 2022;17(11):3121–3130. PMID: 36228140
    Reference Link
  • 1.
    Kayrouz C, Huang J, Hauser N, Seyedsayamdost M. Biosynthesis of selenium-containing small molecules in diverse microorganisms. Nature. 2022;610(7930):199–204. PMCID: 2881734
    Reference Link
  • 1.
    Li Y, Lee S, Han E, Seyedsayamdost M. Momomycin, an Antiproliferative Cryptic Metabolite from the Oxytetracycline Producer Streptomyces rimosus. Angew Chem Int Ed Engl. 2022;61(39):e202208573. PMCID: PMC9489664
    Reference Link
  • 1.
    Lee S, Seyedsayamdost M. Induction of Diverse Cryptic Fungal Metabolites by Steroids and Channel Blockers. Angew Chem Int Ed Engl. 2022;61(29):e202204519. PMCID: PMC9276648
    Reference Link
  • 1.
    Covington B, Seyedsayamdost M. Guidelines for metabolomics-guided transposon mutagenesis for microbial natural product discovery. Methods Enzymol. 2022;665:305–323. PMCID: PMC9078877
    Reference Link
  • 1.
    Matthews B, Dudchenko O, Kingan S, Koren S, Antoshechkin I, Crawford J, Glassford W, Herre M, Redmond S, Rose N, Weedall G, Wu Y, Batra S, Brito-Sierra C, Buckingham S, Campbell C, Chan S, Cox E, Evans B, Fansiri T, Filipović I, Fontaine A, Gloria-Soria A, Hall R, Joardar V, Jones A, Kay R, Kodali V, Lee J, Lycett G, Mitchell S, Muehling J, Murphy M, Omer A, Partridge F, Peluso P, Aiden A, Ramasamy V, Rašić G, Roy S, Saavedra-Rodriguez K, Sharan S, Sharma A, Smith M, Turner J, Weakley A, Zhao Z, Akbari O, Black W, Cao H, Darby A, Hill C, Johnston S, Murphy T, Raikhel A, Sattelle D, Sharakhov I, White B, Zhao L, Aiden E, Mann R, Lambrechts L, Powell J, Sharakhova M, Tu Z, Robertson H, McBride C, Hastie A, Korlach J, Neafsey D, Phillippy A, Vosshall L. Improved reference genome of Aedes aegypti informs arbovirus vector control. Nature. 2018;563(7732):501–507. PMCID: PMC6421076
    Reference Link
  • 1.
    Yoshimura A, Covington B, Gallant Étienne, Zhang C, Li A, Seyedsayamdost M. Unlocking Cryptic Metabolites with Mass Spectrometry-Guided Transposon Mutant Selection. ACS Chem Biol. 2020;15(10):2766–2774. PMCID: PMC7572862
    Reference Link
  • 1.
    Covington B, Xu F, Seyedsayamdost M. A Natural Product Chemist’s Guide to Unlocking Silent Biosynthetic Gene Clusters. Annu Rev Biochem. 2021;90:763–788. PMCID: PMC9148385
    Reference Link
  • 1.
    Kloosterman A, Cimermancic P, Elsayed S, Du C, Hadjithomas M, Donia M, Fischbach M, van Wezel G, Medema M. Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides. PLoS Biol. 2020;18(12):e3001026. PMCID: PMC7794033
    Reference Link
  • 1.
    Klaus J, Coulon P, Koirala P, Seyedsayamdost M, Déziel E, Chandler J. Secondary metabolites from the Burkholderia pseudomallei complex: structure, ecology, and evolution. J Ind Microbiol Biotechnol. 2020;47(9-10):877–887. PMCID: PMC7746414
    Reference Link
  • 1.
    Caruso A, Bushin L, Clark K, Martinie R, Seyedsayamdost M. Radical Approach to Enzymatic β-Thioether Bond Formation. J Am Chem Soc. 2019;141(2):990–997. PMID: 30521328
    Reference Link
  • 1.
    Cheung-Lee W, Cao L, Link J. Pandonodin: A Proteobacterial Lasso Peptide with an Exceptionally Long C-Terminal Tail. ACS Chem Biol. 2019;14(12):2783–2792. PMCID: PMC7010350
    Reference Link
  • 1.
    Li A, Mao D, Yoshimura A, Rosen P, Martin L, Gallant Étienne, Wühr M, Seyedsayamdost M. Multi-Omic Analyses Provide Links between Low-Dose Antibiotic Treatment and Induction of Secondary Metabolism in Burkholderia thailandensis. mBio. 2020;11(1). PMCID: PMC7042699
    Reference Link
  • 1.
    Greenberg P, Chandler J, Seyedsayamdost M. The Chemistry and Biology of Bactobolin: A 10-Year Collaboration with Natural Product Chemist Extraordinaire Jon Clardy. J Nat Prod. 2020;83(3):738–743. PMCID: PMC8118907
    Reference Link
  • 1.
    Mao D, Yoshimura A, Wang R, Seyedsayamdost M. Reporter-Guided Transposon Mutant Selection for Activation of Silent Gene Clusters in Burkholderia thailandensis. Chembiochem. 2020;21(13):1826–1831. PMCID: PMC7493819
    Reference Link
  • 1.
    Park J-D, Moon K, Miller C, Rose J, Xu F, Ebmeier C, Jacobsen J, Mao D, Old W, DeShazer D, Seyedsayamdost M. Thailandenes, Cryptic Polyene Natural Products Isolated from Using Phenotype-Guided Transposon Mutagenesis. ACS Chem Biol. 2020;15(5):1195–1203. PMCID: PMC9106368
    Reference Link
  • 1.
    Sugimoto Y, Camacho F, Wang S, Chankhamjon P, Odabas A, Biswas A, Jeffrey P, Donia M. A metagenomic strategy for harnessing the chemical repertoire of the human microbiome. Science. 2019;366(6471). PMID: 31582523
    Reference Link
  • 1.
    Bushin L, Clark K, Pelczer I, Seyedsayamdost M. Charting an Unexplored Streptococcal Biosynthetic Landscape Reveals a Unique Peptide Cyclization Motif. J Am Chem Soc. 2018;140(50):17674–17684. PMID: 30398325
    Reference Link
  • 1.
    Cheung-Lee W, Link J. Genome mining for lasso peptides: past, present, and future. J Ind Microbiol Biotechnol. 2019;46(9-10):1371–1379. PMCID: PMC6989040
    Reference Link
  • 1.
    Xu F, Wu Y, Zhang C, Davis K, Moon K, Bushin L, Seyedsayamdost M. A genetics-free method for high-throughput discovery of cryptic microbial metabolites. Nat Chem Biol. 2019;15(2):161–168. PMCID: PMC6339573
    Reference Link
  • 1.
    Seyedsayamdost M. Toward a global picture of bacterial secondary metabolism. J Ind Microbiol Biotechnol. 2019;46(3-4):301–311. PMCID: PMC6779422
    Reference Link
  • 1.
    Tuttle R, Demko A, Patin N, Kapono C, Donia M, Dorrestein P, Jensen P. Detection of Natural Products and Their Producers in Ocean Sediments. Appl Environ Microbiol. 2019;85(8). PMCID: PMC6450032
    Reference Link
  • 1.
    Tianero M, Balaich J, Donia M. Localized production of defence chemicals by intracellular symbionts of Haliclona sponges. Nat Microbiol. 2019;4(7):1149–1159. PMCID: PMC8647704
    Reference Link
  • 1.
    Moon K, Xu F, Zhang C, Seyedsayamdost M. Bioactivity-HiTES Unveils Cryptic Antibiotics Encoded in Actinomycete Bacteria. ACS Chem Biol. 2019;14(4):767–774. PMCID: PMC6813803
    Reference Link
  • 1.
    Cheung-Lee W, Parry M, Cartagena A, Darst S, Link J. Discovery and structure of the antimicrobial lasso peptide citrocin. J Biol Chem. 2019;294(17):6822–6830. PMCID: PMC6497930
    Reference Link
  • 1.
    Bushin L, Seyedsayamdost M. Guidelines for Determining the Structures of Radical SAM Enzyme-Catalyzed Modifications in the Biosynthesis of RiPP Natural Products. Methods Enzymol. 2018;606:439–460. PMID: 30097102
    Reference Link
  • 1.
    McRose D, Baars O, Seyedsayamdost M, Morel F. Quorum sensing and iron regulate a two-for-one siderophore gene cluster in . Proc Natl Acad Sci U S A. 2018;115(29):7581–7586. PMCID: PMC6055174
    Reference Link
  • 1.
    Mao D, Bushin L, Moon K, Wu Y, Seyedsayamdost M. Discovery of as a global regulator of secondary metabolism and virulence in E264. Proc Natl Acad Sci U S A. 2017;114(14):E2920-E2928. PMCID: PMC5389298
    Reference Link
  • 1.
    Okada B, Seyedsayamdost M. Antibiotic dialogues: induction of silent biosynthetic gene clusters by exogenous small molecules. FEMS Microbiol Rev. 2017;41(1):19–33. PMCID: PMC5233716
    Reference Link
  • 1.
    Wang R, Gallant Étienne, Seyedsayamdost M. Investigation of the Genetics and Biochemistry of Roseobacticide Production in the Roseobacter Clade Bacterium Phaeobacter inhibens. mBio. 2016;7(2):e02118. PMCID: PMC4807370
    Reference Link
  • 1.
    Seyedsayamdost M. High-throughput platform for the discovery of elicitors of silent bacterial gene clusters. Proc Natl Acad Sci U S A. 2014;111(20):7266–71. PMCID: PMC4034229
    Reference Link
  • 1.
    Rosen P, Seyedsayamdost M. Though Much Is Taken, Much Abides: Finding New Antibiotics Using Old Ones. Biochemistry. 2017;56(37):4925–4926. PMCID: PMC5617734
    Reference Link
  • 1.
    Geronimo C, Zakian V. Getting it done at the ends: Pif1 family DNA helicases and telomeres. DNA Repair (Amst). 2016;44:151–158. PMCID: PMC5441554
    Reference Link
  • 1.
    Diner B, Li T, Greco T, Crow M, Fuesler J, Wang J, Cristea I. The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Mol Syst Biol. 2015;11(1):787. PMCID: PMC4358659
    Reference Link
  • 1.
    vonHoldt B, Takuno S, Gaut B. Recent retrotransposon insertions are methylated and phylogenetically clustered in japonica rice (Oryza sativa spp. japonica). Mol Biol Evol. 2012;29(10):3193–203. PMID: 22593226
    Reference Link
  • 1.
    Pritykin Y, Ghersi D, Singh M. Genome-Wide Detection and Analysis of Multifunctional Genes. PLoS Comput Biol. 2015;11(10):e1004467. PMCID: PMC4593560
    Reference Link
  • 1.
    Seyedsayamdost M, Cleto S, Carr G, Vlamakis H, Vieira M, Kolter R, Clardy J. Mixing and matching siderophore clusters: structure and biosynthesis of serratiochelins from Serratia sp. V4. J Am Chem Soc. 2012;134(33):13550–3. PMCID: PMC3424848
    Reference Link
  • 1.
    Donia M, Cimermancic P, Schulze C, Brown L, Martin J, Mitreva M, Clardy J, Linington R, Fischbach M. A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics. Cell. 2014;158(6):1402–1414. PMCID: PMC4164201
    Reference Link
  • 1.
    Medema M, Kottmann R, Yilmaz P, Cummings M, Biggins J, Blin K, de Bruijn I, Chooi Y, Claesen J, Coates C, Cruz-Morales P, Duddela S, Düsterhus S, Edwards D, Fewer D, Garg N, Geiger C, Gomez-Escribano J, Greule A, Hadjithomas M, Haines A, Helfrich E, Hillwig M, Ishida K, Jones A, Jones C, Jungmann K, Kegler C, Kim H, Kötter P, Krug D, Masschelein J, Melnik A, Mantovani S, Monroe E, Moore M, Moss N, Nützmann H-W, Pan G, Pati A, Petras D, Reen J, Rosconi F, Rui Z, Tian Z, Tobias N, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel A, Balibar C, Balskus E, Barona-Gómez F, Bechthold A, Bode H, Borriss R, Brady S, Brakhage A, Caffrey P, Cheng Y-Q, Clardy J, Cox R, De Mot R, Donadio S, Donia M, van der Donk W, Dorrestein P, Doyle S, Driessen A, Ehling-Schulz M, Entian K-D, Fischbach M, Gerwick L, Gerwick W, Gross H, Gust B, Hertweck C, Höfte M, Jensen S, Ju J, Katz L, Kaysser L, Klassen J, Keller N, Kormanec J, Kuipers O, Kuzuyama T, Kyrpides N, Kwon H-J, Lautru S, Lavigne R, Lee C, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell D, Moore B, Moreira L, Müller R, Neilan B, Nett M, Nielsen J, O’Gara F, Oikawa H, Osbourn A, Osburne M, Ostash B, Payne S, Pernodet J-L, Petricek M, Piel J, Ploux O, Raaijmakers J, Salas J, Schmitt E, Scott B, Seipke R, Shen B, Sherman D, Sivonen K, Smanski M, Sosio M, Stegmann E, Süssmuth R, Tahlan K, Thomas C, Tang Y, Truman A, Viaud M, Walton J, Walsh C, Weber T, van Wezel G, Wilkinson B, Willey J, Wohlleben W, Wright G, Ziemert N, Zhang C, Zotchev S, Breitling R, Takano E, Glöckner F. Minimum Information about a Biosynthetic Gene cluster. Nat Chem Biol. 2015;11(9):625–31. PMCID: PMC5714517
    Reference Link
  • 1.
    Surette M, Miller M, Bassler B. Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production. Proc Natl Acad Sci U S A. 1999;96(4):1639–44. PMCID: PMC15544
    Reference Link
  • 1.
    Schauder S, Shokat K, Surette M, Bassler B. The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule. Mol Microbiol. 2001;41(2):463–76. PMID: 11489131
    Reference Link
  • 1.
    Henke J, Bassler B. Quorum sensing regulates type III secretion in Vibrio harveyi and Vibrio parahaemolyticus. J Bacteriol. 2004;186(12):3794–805. PMCID: PMC419960
    Reference Link

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