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Mitochondria

  • 1.
    Du J, Estrella M, Solorio-Kirpichyan K, Jeffrey P, Korennykh A. Structure of human NADK2 reveals atypical assembly and regulation of NAD kinases from animal mitochondria. Proc Natl Acad Sci U S A. 2022;119(26):e2200923119. PMCID: PMC9245612
    Reference Link
  • 1.
    Olszewski K, Barsotti A, Feng X-J, Momcilovic M, Liu K, Kim J-I, Morris K, Lamarque C, Gaffney J, Yu X, Patel J, Rabinowitz J, Shackelford D, Poyurovsky M. Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors. Cell Chem Biol. 2022;29(3):423–435.e10. PMID: 34715056
    Reference Link
  • 1.
    Elshina E, Velthuis A. The influenza virus RNA polymerase as an innate immune agonist and antagonist. Cell Mol Life Sci. 2021;78(23):7237–7256. PMCID: PMC8532088
    Reference Link
  • 1.
    Betsinger C, Jankowski C, Hofstadter W, Federspiel J, Otter C, Beltran P, Cristea I. The human cytomegalovirus protein pUL13 targets mitochondrial cristae architecture to increase cellular respiration during infection. Proc Natl Acad Sci U S A. 2021;118(32). PMCID: PMC8364163
    Reference Link
  • 1.
    Sheng X, Cristea I. The antiviral sirtuin 3 bridges protein acetylation to mitochondrial integrity and metabolism during human cytomegalovirus infection. PLoS Pathog. 2021;17(4):e1009506. PMCID: PMC8078788
    Reference Link
  • 1.
    Minhas P, Latif-Hernandez A, McReynolds M, Durairaj A, Wang Q, Rubin A, Joshi A, He J, Gauba E, Liu L, Wang C, Linde M, Sugiura Y, Moon P, Majeti R, Suematsu M, Mochly-Rosen D, Weissman I, Longo F, Rabinowitz J, Andreasson K. Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Nature. 2021;590(7844):122–128. PMCID: PMC8274816
    Reference Link
  • 1.
    Parkhitko A, Ramesh D, Wang L, Leshchiner D, Filine E, Binari R, Olsen A, Asara J, Cracan V, Rabinowitz J, Brockmann A, Perrimon N. Downregulation of the tyrosine degradation pathway extends lifespan. Elife. 2020;9. PMCID: PMC7744100
    Reference Link
  • 1.
    Mor D, Sohrabi S, Kaletsky R, Keyes W, Tartici A, Kalia V, Miller G, Murphy C. Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria. Proc Natl Acad Sci U S A. 2020;117(42):26438–26447. PMCID: PMC7585014
    Reference Link
  • 1.
    Luongo T, Eller J, Lu M-J, Niere M, Raith F, Perry C, Bornstein M, Oliphint P, Wang L, McReynolds M, Migaud M, Rabinowitz J, Johnson B, Johnsson K, Ziegler M, Cambronne X, Baur J. SLC25A51 is a mammalian mitochondrial NAD transporter. Nature. 2020;588(7836):174–179. PMCID: PMC7718333
    Reference Link
  • 1.
    Federspiel J, Cook K, Kennedy M, Venkatesh S, Otter C, Hofstadter W, Beltran P, Cristea I. Mitochondria and Peroxisome Remodeling across Cytomegalovirus Infection Time Viewed through the Lens of Inter-ViSTA. Cell Rep. 2020;32(4):107943. PMCID: PMC8489195
    Reference Link
  • 1.
    Duran L, López J, Avalos J. ¡Viva la mitochondria!: harnessing yeast mitochondria for chemical production. FEMS Yeast Res. 2020;20(6). PMID: 32592388
    Reference Link
  • 1.
    Betsinger C, Cristea I. Mitochondrial Function, Metabolic Regulation, and Human Disease Viewed through the Prism of Sirtuin 4 (SIRT4) Functions. J Proteome Res. 2019;18(5):1929–1938. PMCID: PMC6889813
    Reference Link
  • 1.
    Yang L, Canaveras J, Chen Z, Wang L, Liang L, Jang C, Mayr J, Zhang Z, Ghergurovich J, Zhan L, Joshi S, Hu Z, McReynolds M, Su X, White E, Morscher R, Rabinowitz J. Serine Catabolism Feeds NADH when Respiration Is Impaired. Cell Metab. 2020;31(4):809–821.e6. PMCID: PMC7397714
    Reference Link
  • 1.
    Hammer S, Zhang Y, Avalos J. Mitochondrial Compartmentalization Confers Specificity to the 2-Ketoacid Recursive Pathway: Increasing Isopentanol Production in . ACS Synth Biol. 2020;9(3):546–555. PMID: 32049515
    Reference Link
  • 1.
    Li A, Ducker G, Li Y, Seoane J, Xiao Y, Melemenidis S, Zhou Y, Liu L, Vanharanta S, Graves E, Rankin E, Curtis C, Massagué J, Rabinowitz J, Thompson C, Ye J. Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism. Mol Cancer Res. 2020;18(4):599–611. PMCID: PMC7127984
    Reference Link
  • 1.
    Dekhne A, Shah K, Ducker G, Katinas J, Wong-Roushar J, Nayeen M, Doshi A, Ning C, Bao X, Frühauf J, Liu J, Wallace-Povirk A, O’Connor C, Dzinic S, White K, Kushner J, Kim S, Hüttemann M, Polin L, Rabinowitz J, Li J, Hou Z, Dann C, Gangjee A, Matherly L. Novel Pyrrolo[3,2-]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy. Mol Cancer Ther. 2019;18(10):1787–1799. PMCID: PMC6774887
    Reference Link
  • 1.
    Minhas P, Liu L, Moon P, Joshi A, Dove C, Mhatre S, Contrepois K, Wang Q, Lee B, Coronado M, Bernstein D, Snyder M, Migaud M, Majeti R, Mochly-Rosen D, Rabinowitz J, Andreasson K. Macrophage de novo NAD synthesis specifies immune function in aging and inflammation. Nat Immunol. 2019;20(1):50–63. PMCID: PMC6768398
    Reference Link
  • 1.
    Ron-Harel N, Notarangelo G, Ghergurovich J, Paulo J, Sage P, Santos D, Satterstrom K, Gygi S, Rabinowitz J, Sharpe A, Haigis M. Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. Proc Natl Acad Sci U S A. 2018;115(52):13347–13352. PMCID: PMC6310842
    Reference Link
  • 1.
    Geronimo C, Singh S, Galletto R, Zakian V. The signature motif of the Saccharomyces cerevisiae Pif1 DNA helicase is essential in vivo for mitochondrial and nuclear functions and in vitro for ATPase activity. Nucleic Acids Res. 2018;46(16):8357–8370. PMCID: PMC6144861
    Reference Link
  • 1.
    Jang C, Chen L, Rabinowitz J. Metabolomics and Isotope Tracing. Cell. 2018;173(4):822–837. PMCID: PMC6034115
    Reference Link
  • 1.
    Zhang Y, Avalos J. Traditional and novel tools to probe the mitochondrial metabolism in health and disease. Wiley Interdiscip Rev Syst Biol Med. 2017;9(2). PMID: 28067471
    Reference Link
  • 1.
    Morscher R, Ducker G, Li S, Mayer J, Gitai Z, Sperl W, Rabinowitz J. Mitochondrial translation requires folate-dependent tRNA methylation. Nature. 2018;554(7690):128–132. PMCID: PMC6020024
    Reference Link
  • 1.
    Yan N. Structural investigation of the proton-coupled secondary transporters. Curr Opin Struct Biol. 2013;23(4):483–91. PMID: 23806360
    Reference Link
  • 1.
    Mirzaei M, Gupta V, Chick J, Greco T, Wu Y, Chitranshi N, Wall R, Hone E, Deng L, Dheer Y, Abbasi M, Rezaeian M, Braidy N, You Y, Salekdeh G, Haynes P, Molloy M, Martins R, Cristea I, Gygi S, Graham S, Gupta V. Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes. Sci Rep. 2017;7(1):12685. PMCID: PMC5627288
    Reference Link
  • 1.
    Ron-Harel N, Santos D, Ghergurovich J, Sage P, Reddy A, Lovitch S, Dephoure N, Satterstrom K, Sheffer M, Spinelli J, Gygi S, Rabinowitz J, Sharpe A, Haigis M. Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metab. 2016;24(1):104–17. PMCID: PMC5330619
    Reference Link
  • 1.
    Frederick D, Loro E, Liu L, Davila A, Chellappa K, Silverman I, Quinn W, Gosai S, Tichy E, Davis J, Mourkioti F, Gregory B, Dellinger R, Redpath P, Migaud M, Nakamaru-Ogiso E, Rabinowitz J, Khurana T, Baur J. Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metab. 2016;24(2):269–82. PMCID: PMC4985182
    Reference Link
  • 1.
    Guo J, Teng X, Laddha S, Ma S, Van Nostrand S, Yang Y, Khor S, Chan C, Rabinowitz J, White E. Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes Dev. 2016;30(15):1704–17. PMCID: PMC5002976
    Reference Link
  • 1.
    Ducker G, Chen L, Morscher R, Ghergurovich J, Esposito M, Teng X, Kang Y, Rabinowitz J. Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway. Cell Metab. 2016;23(6):1140–1153. PMCID: PMC4909566
    Reference Link
  • 1.
    Mathias R, Greco T, Cristea I. Identification of Sirtuin4 (SIRT4) Protein Interactions: Uncovering Candidate Acyl-Modified Mitochondrial Substrates and Enzymatic Regulators. Methods Mol Biol. 2016;1436:213–39. PMCID: PMC4919573
    Reference Link
  • 1.
    Bhogal B, Plaza-Jennings A, Gavis E. Nanos-mediated repression of hid protects larval sensory neurons after a global switch in sensitivity to apoptotic signals. Development. 2016;143(12):2147–59. PMCID: PMC4920170
    Reference Link
  • 1.
    Ducker G, Rabinowitz J. One-Carbon Metabolism in Health and Disease. Cell Metab. 2017;25(1):27–42. PMCID: PMC5353360
    Reference Link
  • 1.
    Zong W-X, Rabinowitz J, White E. Mitochondria and Cancer. Mol Cell. 2016;61(5):667–676. PMCID: PMC4779192
    Reference Link
  • 1.
    Avalos J, Fink G, Stephanopoulos G. Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols. Nat Biotechnol. 2013;31(4):335–41. PMCID: PMC3659820
    Reference Link
  • 1.
    Kwan J, Tianero M, Donia M, Wyche T, Bugni T, Schmidt E. Host control of symbiont natural product chemistry in cryptic populations of the tunicate Lissoclinum patella. PLoS One. 2014;9(5):e95850. PMCID: PMC4008419
    Reference Link

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