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Mice

  • 1.
    Son J, Du W, Esposito M, Shariati K, Ding H, Kang Y, Accili D. Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure. Nat Commun. 2023;14(1):558. PMCID: PMC9895451
    Reference Link
  • 1.
    Bartman C, Weilandt D, Shen Y, Lee W, Han Y, TeSlaa T, Jankowski C, Samarah L, Park N, da Silva-Diz V, Aleksandrova M, Gultekin Y, Marishta A, Wang L, Yang L, Roichman A, Bhatt V, Lan T, Hu Z, Xing X, Lu W, Davidson S, Wühr M, Heiden M, Herranz D, Guo J, Kang Y, Rabinowitz J. Slow TCA flux and ATP production in primary solid tumours but not metastases. Nature. 2023;614(7947):349–357. PMID: 36725930
    Reference Link
  • 1.
    Douam F, Ploss A. A humanized "new-trophil" mouse to study early inflammatory processes. Proc Natl Acad Sci U S A. 2022;119(49):e2216699119. PMCID: PMC9894160
    Reference Link
  • 1.
    Chellappa K, McReynolds M, Lu W, Zeng X, Makarov M, Hayat F, Mukherjee S, Bhat Y, Lingala S, Shima R, Descamps H, Cox T, Ji L, Jankowski C, Chu Q, Davidson S, Thaiss C, Migaud M, Rabinowitz J, Baur J. NAD precursors cycle between host tissues and the gut microbiome. Cell Metab. 2022;34(12):1947–1959.e5. PMCID: PMC9825113
    Reference Link
  • 1.
    Zhao H, Teng D, Yang L, Xu X, Chen J, Jiang T, Feng A, Zhang Y, Frederick D, Gu L, Cai L, Asara J, di Magliano M, Boland G, Flaherty K, Swanson K, Liu D, Rabinowitz J, Zheng B. Myeloid-derived itaconate suppresses cytotoxic CD8 T cells and promotes tumour growth. Nat Metab. 2022;4(12):1660–1673. PMID: 36376563
    Reference Link
  • 1.
    Paramore S, Goodwin K, Nelson C. How to build an epithelial tree. Phys Biol. 2022;19(6). PMID: 36317265
    Reference Link
  • 1.
    Zeng X, Xing X, Gupta M, Keber F, Lopez J, Lee Y-C, Roichman A, Wang L, Neinast M, Donia M, Wühr M, Jang C, Rabinowitz J. Gut bacterial nutrient preferences quantified in vivo. Cell. 2022;185(18):3441–3456.e19. PMCID: PMC9450212
    Reference Link
  • 1.
    Jankowski C, Rabinowitz J. Selenium Modulates Cancer Cell Response to Pharmacologic Ascorbate. Cancer Res. 2022;82(19):3486–3498. PMCID: PMC9532358
    Reference Link
  • 1.
    Kennedy M, Greco T, Song B, Cristea I. HTT-OMNI: A Web-based Platform for Huntingtin Interaction Exploration and Multi-omics Data Integration. Mol Cell Proteomics. 2022;21(10):100275. PMCID: PMC9540350
    Reference Link
  • 1.
    Taylor I, Jeffrey P, Moustafa D, Goldberg J, Bassler B. The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against . Biochemistry. 2022;61(17):1894–1903. PMCID: PMC9454246
    Reference Link
  • 1.
    Lim A, Menegatti S, Bustamante J, Le Bourhis L, Allez M, Rogge L, Casanova J-L, Yssel H, Di Santo J. IL-12 drives functional plasticity of human group 2 innate lymphoid cells. J Exp Med. 2016;213(4):569–83. PMCID: PMC4821648
    Reference Link
  • 1.
    Lim A, Verrier T, Vosshenrich C, Di Santo J. Developmental options and functional plasticity of innate lymphoid cells. Curr Opin Immunol. 2017;44:61–68. PMID: 28359987
    Reference Link
  • 1.
    Lim A, Li Y, Lopez-Lastra S, Stadhouders R, Paul F, Casrouge A, Serafini N, Puel A, Bustamante J, Surace L, Masse-Ranson G, David E, Strick-Marchand H, Le Bourhis L, Cocchi R, Topazio D, Graziano P, Muscarella L, Rogge L, Norel X, Sallenave J-M, Allez M, Graf T, Hendriks R, Casanova J-L, Amit I, Yssel H, Di Santo J. Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation. Cell. 2017;168(6):1086–1100.e10. PMID: 28283063
    Reference Link
  • 1.
    Lim A, McFadden T, Link V, Han S-J, Karlsson R-M, Stacy A, Farley T, Lima-Junior D, Harrison O, Desai J, Lionakis M, Shih H-Y, Cameron H, Belkaid Y. Prenatal maternal infection promotes tissue-specific immunity and inflammation in offspring. Science. 2021;373(6558). PMID: 34446580
    Reference Link
  • 1.
    Pisano T, Hoag A, Dhanerawala Z, Guariglia S, Jung C, Boele H-J, Seagraves K, Verpeut J, Wang S. Automated high-throughput mouse transsynaptic viral tracing using iDISCO+ tissue clearing, light-sheet microscopy, and BrainPipe. STAR Protoc. 2022;3(2):101289. PMCID: PMC9038781
    Reference Link
  • 1.
    Yang D, Jones M, Naranjo S, Rideout W, Min K, Ho R, Wu W, Replogle J, Page J, Quinn J, Horns F, Qiu X, Chen M, Freed-Pastor W, McGinnis C, Patterson D, Gartner Z, Chow E, Bivona T, Chan M, Yosef N, Jacks T, Weissman J. Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution. Cell. 2022;185(11):1905–1923.e25. PMCID: PMC9452598
    Reference Link
  • 1.
    Chen X, Du Y, Broussard G, Kislin M, Yuede C, Zhang S, Dietmann S, Gabel H, Zhao G, Wang S, Zhang X, Bonni A. Transcriptomic mapping uncovers Purkinje neuron plasticity driving learning. Nature. 2022;605(7911):722–727. PMCID: PMC9887520
    Reference Link
  • 1.
    Kenney D, O’Connell A, Turcinovic J, Montanaro P, Hekman R, Tamura T, Berneshawi A, Cafiero T, Abdullatif S, Blum B, Goldstein S, Heller B, Gertje H, Bullitt E, Trachtenberg A, Chavez E, Nono E, Morrison C, Tseng A, Sheikh A, Kurnick S, Grosz K, Bosmann M, Ericsson M, Huber B, Saeed M, Balazs A, Francis K, Klose A, Paragas N, Campbell J, Connor J, Emili A, Crossland N, Ploss A, Douam F. Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection. Cell Rep. 2022;39(3):110714. PMCID: PMC8977517
    Reference Link
  • 1.
    Yang L, TeSlaa T, Ng S, Nofal M, Wang L, Lan T, Zeng X, Cowan A, McBride M, Lu W, Davidson S, Liang G, Oh T, Downes M, Evans R, Von Hoff D, Guo J, Han H, Rabinowitz J. Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth. Med. 2022;3(2):119–136. PMCID: PMC9004683
    Reference Link
  • 1.
    Nelson C. Mechanical Control of Cell Differentiation: Insights from the Early Embryo. Annu Rev Biomed Eng. 2022;24:307–322. PMID: 35385680
    Reference Link
  • 1.
    Pereira T, Tabris N, Matsliah A, Turner D, Li J, Ravindranath S, Papadoyannis E, Normand E, Deutsch D, Wang Y, McKenzie-Smith G, Mitelut C, Castro M, D’Uva J, Kislin M, Sanes D, Kocher S, Wang S, Falkner A, Shaevitz J, Murthy M. SLEAP: A deep learning system for multi-animal pose tracking. Nat Methods. 2022;19(4):486–495. PMCID: PMC9007740
    Reference Link
  • 1.
    Buksh B, Knutson S, Oakley J, Bissonnette N, Oblinsky D, Schwoerer M, Seath C, Geri J, Rodriguez-Rivera F, Parker D, Scholes G, Ploss A, MacMillan D. μMap-Red: Proximity Labeling by Red Light Photocatalysis. J Am Chem Soc. 2022;144(14):6154–6162. PMCID: PMC9843638
    Reference Link
  • 1.
    Wang R, Suzuki S, Guest J, Heller B, Almeda M, Andrianov A, Marin A, Mariuzza R, Keck Z-Y, Foung S, Yunus A, Pierce B, Toth E, Ploss A, Fuerst T. Induction of broadly neutralizing antibodies using a secreted form of the hepatitis C virus E1E2 heterodimer as a vaccine candidate. Proc Natl Acad Sci U S A. 2022;119(11):e2112008119. PMCID: PMC8931252
    Reference Link
  • 1.
    Klibaite U, Kislin M, Verpeut J, Bergeler S, Sun X, Shaevitz J, Wang S. Deep phenotyping reveals movement phenotypes in mouse neurodevelopmental models. Mol Autism. 2022;13(1):12. PMCID: PMC8917660
    Reference Link
  • 1.
    Pisano T, Dhanerawala Z, Kislin M, Bakshinskaya D, Engel E, Hansen E, Hoag A, Lee J, de Oude N, Venkataraju K, Verpeut J, Hoebeek F, Richardson B, Boele H-J, Wang S. Homologous organization of cerebellar pathways to sensory, motor, and associative forebrain. Cell Rep. 2021;36(12):109721. PMCID: PMC8506234
    Reference Link
  • 1.
    Broussard G, Kislin M, Jung C, Wang S. A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning. J Vis Exp. 2022;(179). PMCID: PMC9118201
    Reference Link
  • 1.
    Greco T, Secker C, Ramos E, Federspiel J, Liu J-P, Perez A, Al-Ramahi I, Cantle J, Carroll J, Botas J, Zeitlin S, Wanker E, Cristea I. Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease. Cell Syst. 2022;13(4):304–320.e5. PMCID: PMC9317655
    Reference Link
  • 1.
    Shen M, Wei Y, Kim H, Wan L, Jiang Y-Z, Hang X, Raba M, Remiszewski S, Rowicki M, Wu C-G, Wu S, Zhang L, Lu X, Yuan M, Smith H, Zheng A, Bertino J, Jin J, Xing Y, Shao Z-M, Kang Y. Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis. Nat Cancer. 2022;3(1):43–59. PMCID: PMC8818087
    Reference Link
  • 1.
    Li X, Hui S, Mirek E, Jonsson W, Anthony T, Lee W, Zeng X, Jang C, Rabinowitz J. Circulating metabolite homeostasis achieved through mass action. Nat Metab. 2022;4(1):141–152. PMCID: PMC9244777
    Reference Link
  • 1.
    Jaslove J, Goodwin K, Sundarakrishnan A, Spurlin J, Mao S, Košmrlj A, Nelson C. Transmural pressure signals through retinoic acid to regulate lung branching. Development. 2022;149(2). PMCID: PMC8917413
    Reference Link
  • 1.
    Tamura T, Zhang J, Madan V, Biswas A, Schwoerer M, Cafiero T, Heller B, Wang W, Ploss A. Generation and characterization of genetically and antigenically diverse infectious clones of dengue virus serotypes 1-4. Emerg Microbes Infect. 2022;11(1):227–239. PMCID: PMC8745371
    Reference Link
  • 1.
    Doherty C, Amargant F, Shvartsman S, Duncan F, Gavis E. Bidirectional communication in oogenesis: a dynamic conversation in mice and Drosophila. Trends Cell Biol. 2022;32(4):311–323. PMCID: PMC8917990
    Reference Link
  • 1.
    Sugiura A, Andrejeva G, Voss K, Heintzman D, Xu X, Madden M, Ye X, Beier K, Chowdhury N, Wolf M, Young A, Greenwood D, Sewell A, Shahi S, Freedman S, Cameron A, Foerch P, Bourne T, García-Cañaveras J, Karijolich J, Newcomb D, Mangalam A, Rabinowitz J, Rathmell J. MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. Immunity. 2022;55(1):65–81.e9. PMCID: PMC8755618
    Reference Link
  • 1.
    Zhang Z, TeSlaa T, Xu X, Zeng X, Yang L, Xing G, Tesz G, Clasquin M, Rabinowitz J. Serine catabolism generates liver NADPH and supports hepatic lipogenesis. Nat Metab. 2021;3(12):1608–1620. PMCID: PMC8721747
    Reference Link
  • 1.
    Chen L, Lu W, Wang L, Xing X, Chen Z, Teng X, Zeng X, Muscarella A, Shen Y, Cowan A, McReynolds M, Kennedy B, Lato A, Campagna S, Singh M, Rabinowitz J. Metabolite discovery through global annotation of untargeted metabolomics data. Nat Methods. 2021;18(11):1377–1385. PMCID: PMC8733904
    Reference Link
  • 1.
    Nofal M, Wang T, Yang L, Jankowski C, Li S, Han S, Parsons L, Frese A, Gitai Z, Anthony T, Wühr M, Sabatini D, Rabinowitz J. GCN2 adapts protein synthesis to scavenging-dependent growth. Cell Syst. 2022;13(2):158–172.e9. PMCID: PMC8961722
    Reference Link
  • 1.
    Wilke A, Doebele C, Zindel A, Lee K, Rieke S, Ceribelli M, Comoglio F, Phelan J, Wang J, Pikman Y, Jahn D, Häupl B, Schneider C, Scheich S, Tosto F, Bohnenberger H, Stauder P, Schnütgen F, Slabicki M, Coulibaly Z, Wolf S, Bojarczuk K, Chapuy B, Brandts C, Stroebel P, Lewis C, Engelke M, Xu X, Kim H, Dang T, Schmitz R, Hodson D, Stegmaier K, Urlaub H, Serve H, Schmitt C, Kreuz F, Knittel G, Rabinowitz J, Reinhardt H, Heiden M, Thomas C, Staudt L, Zenz T, Oellerich T. SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. Blood. 2022;139(4):538–553. PMCID: PMC8938936
    Reference Link
  • 1.
    Shi W, Sheng X, Dorr K, Hutton J, Emerson J, Davies H, Andrade T, Wasson L, Greco T, Hashimoto Y, Federspiel J, Robbe Z, Chen X, Arnold A, Cristea I, Conlon F. Cardiac proteomics reveals sex chromosome-dependent differences between males and females that arise prior to gonad formation. Dev Cell. 2021;56(21):3019–3034.e7. PMCID: PMC9290207
    Reference Link
  • 1.
    McReynolds M, Chellappa K, Chiles E, Jankowski C, Shen Y, Chen L, Descamps H, Mukherjee S, Bhat Y, Lingala S, Chu Q, Botolin P, Hayat F, Doke T, Susztak K, Thaiss C, Lu W, Migaud M, Su X, Rabinowitz J, Baur J. NAD flux is maintained in aged mice despite lower tissue concentrations. Cell Syst. 2021;12(12):1160–1172.e4. PMCID: PMC8678178
    Reference Link
  • 1.
    García-Cañaveras J, Heo D, Trefely S, Leferovich J, Xu C, Philipson B, Ghassemi S, Milone M, Moon E, Snyder N, June C, Rabinowitz J, O’Connor R. CAR T-Cells Depend on the Coupling of NADH Oxidation with ATP Production. Cells. 2021;10(9). PMCID: PMC8472053
    Reference Link
  • 1.
    Maerker M, Getwan M, Dowdle M, McSheene J, Gonzalez V, Pelliccia J, Hamilton D, Yartseva V, Vejnar C, Tingler M, Minegishi K, Vick P, Giraldez A, Hamada H, Burdine R, Sheets M, Blum M, Schweickert A. Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5. Nat Commun. 2021;12(1):5482. PMCID: PMC8446035
    Reference Link
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    Sochacki K, Heine B, Haber G, Jimah J, Prasai B, Alfonzo-Méndez M, Roberts A, Somasundaram A, Hinshaw J, Taraska J. The structure and spontaneous curvature of clathrin lattices at the plasma membrane. Dev Cell. 2021;56(8):1131–1146.e3. PMCID: PMC8081270
    Reference Link
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    Lindström N, Sealfon R, Chen X, Parvez R, Ransick A, Brandine G, Guo J, Hill B, Tran T, Kim A, Zhou J, Tadych A, Watters A, Wong A, Lovero E, Grubbs B, Thornton M, McMahon J, Smith A, Ruffins S, Armit C, Troyanskaya O, McMahon A. Spatial transcriptional mapping of the human nephrogenic program. Dev Cell. 2021;56(16):2381–2398.e6. PMCID: PMC8396064
    Reference Link
  • 1.
    Aubry F, Dabo S, Manet C, Filipović I, Rose N, Miot E, Martynow D, Baidaliuk A, Merkling S, Dickson L, Crist A, Anyango V, Romero-Vivas C, Vega-Rúa A, Dusfour I, Jiolle D, Paupy C, Mayanja M, Lutwama J, Kohl A, Duong V, Ponlawat A, Sylla M, Akorli J, Otoo S, Lutomiah J, Sang R, Mutebi J-P, Cao-Lormeau V-M, Jarman R, Diagne C, Faye O, Faye O, Sall A, McBride C, Montagutelli X, Rašić G, Lambrechts L. Enhanced Zika virus susceptibility of globally invasive populations. Science. 2020;370(6519):991–996. PMID: 33214283
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    Kumar S, Nandi A, Singh S, Regulapati R, Li N, Tobias J, Siebel C, Blanco M, Klein-Szanto A, Lengner C, Welm A, Kang Y, Chakrabarti R. Dll1 quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway. Nat Commun. 2021;12(1):432. PMCID: PMC7813834
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    Shim G, Devenport D, Cohen D. Overriding native cell coordination enhances external programming of collective cell migration. Proc Natl Acad Sci U S A. 2021;118(29). PMCID: PMC8307614
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  • 1.
    Basta L, Hill-Oliva M, Paramore S, Sharan R, Goh A, Biswas A, Cortez M, Little K, Posfai E, Devenport D. New mouse models for high resolution and live imaging of planar cell polarity proteins in vivo. Development. 2021;148(18). PMCID: PMC8487645
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  • 1.
    Quinn J, Jones M, Okimoto R, Nanjo S, Chan M, Yosef N, Bivona T, Weissman J. Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts. Science. 2021;371(6532). PMCID: PMC7983364
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    Dine E, Reed E, Toettcher J. Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch. Cell Rep. 2021;35(12):109280. PMCID: PMC8292983
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  • 1.
    Phan T, Nguyen V, Buettner R, Morales C, Yang L, Wong P, Tsai W, Salazar M, Gil Z, Diamond D, Rabinowitz J, Rosen S, Melstrom L. Inhibition of pyrimidine synthesis augments Gemcitabine induced growth inhibition in an immunocompetent model of pancreatic cancer. Int J Biol Sci. 2021;17(9):2240–2251. PMCID: PMC8241727
    Reference Link

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