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Methylation

  • 1.
    Ghergurovich J, Xu X, Wang J, Yang L, Ryseck R-P, Wang L, Rabinowitz J. Methionine synthase supports tumour tetrahydrofolate pools. Nat Metab. 2021;3(11):1512–1520. PMCID: PMC9284419
    Reference Link
  • 1.
    Song H, Burton A, Shirran S, Fahrig-Kamarauskaitė J, Kaspar H, Muir T, Künzler M, Naismith J. Engineering of a Peptide α-N-Methyltransferase to Methylate Non-Proteinogenic Amino Acids. Angew Chem Int Ed Engl. 2021;60(26):14319–14323. PMCID: PMC8251615
    Reference Link
  • 1.
    Zhao S, Chuh K, Zhang B, Dul B, Thompson R, Farrelly L, Liu X, Xu N, Xue Y, Roeder R, Maze I, Muir T, Li H. Histone H3Q5 serotonylation stabilizes H3K4 methylation and potentiates its readout. Proc Natl Acad Sci U S A. 2021;118(6). PMCID: PMC8017887
    Reference Link
  • 1.
    Strom A, Biggs R, Banigan E, Wang X, Chiu K, Herman C, Collado J, Yue F, Politz J, Tait L, Scalzo D, Telling A, Groudine M, Brangwynne C, Marko J, Stephens A. HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics. Elife. 2021;10. PMCID: PMC8233041
    Reference Link
  • 1.
    Leicher R, Ge E, Lin X, Reynolds M, Xie W, Walz T, Zhang B, Muir T, Liu S. Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin. Proc Natl Acad Sci U S A. 2020;117(48):30465–30475. PMCID: PMC7720148
    Reference Link
  • 1.
    Montalbán-López M, Scott T, Ramesh S, Rahman I, van Heel A, Viel J, Bandarian V, Dittmann E, Genilloud O, Goto Y, Burgos M, Hill C, Kim S, Koehnke J, Latham J, Link J, Martínez B, Nair S, Nicolet Y, Rebuffat S, Sahl H-G, Sareen D, Schmidt E, Schmitt L, Severinov K, Süssmuth R, Truman A, Wang H, Weng J-K, van Wezel G, Zhang Q, Zhong J, Piel J, Mitchell D, Kuipers O, van der Donk W. New developments in RiPP discovery, enzymology and engineering. Nat Prod Rep. 2021;38(1):130–239. PMCID: PMC7864896
    Reference Link
  • 1.
    Anlas A, Nelson C. Living under Strain: How Epithelia Protect Their Genomes from Repeated Stretching. Biochemistry. 2020;59(30):2761–2763. PMID: 32702973
    Reference Link
  • 1.
    Garcia D, Leach R, Wadsworth G, Choudhary K, Li H, Aviran S, Kim H, Zakian V. Stability and nuclear localization of yeast telomerase depend on protein components of RNase P/MRP. Nat Commun. 2020;11(1):2173. PMCID: PMC7195438
    Reference Link
  • 1.
    Seo K, Kleiner R. YTHDF2 Recognition of N-Methyladenosine (mA)-Modified RNA Is Associated with Transcript Destabilization. ACS Chem Biol. 2020;15(1):132–139. PMCID: PMC7025767
    Reference Link
  • 1.
    Albig C, Wang C, Dann G, Wojcik F, Schauer T, Krause S, Maenner S, Cai W, Li Y, Girton J, Muir T, Johansen J, Johansen K, Becker P, Regnard C. JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila. Nat Commun. 2019;10(1):5343. PMCID: PMC6877644
    Reference Link
  • 1.
    Farrelly L, Thompson R, Zhao S, Lepack A, Lyu Y, Bhanu N, Zhang B, Loh Y-H, Ramakrishnan A, Vadodaria K, Heard K, Erikson G, Nakadai T, Bastle R, Lukasak B, Zebroski H, Alenina N, Bader M, Berton O, Roeder R, Molina H, Gage F, Shen L, Garcia B, Li H, Muir T, Maze I. Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature. 2019;567(7749):535–539. PMCID: PMC6557285
    Reference Link
  • 1.
    Nacev B, Feng L, Bagert J, Lemiesz A, Gao J, Soshnev A, Kundra R, Schultz N, Muir T, Allis D. The expanding landscape of ’oncohistone’ mutations in human cancers. Nature. 2019;567(7749):473–478. PMCID: PMC6512987
    Reference Link
  • 1.
    Jeon J, McGinty R, Muir T, Kim J-A, Kim J. Crosstalk among Set1 complex subunits involved in H2B ubiquitylation-dependent H3K4 methylation. Nucleic Acids Res. 2018;46(21):11129–11143. PMCID: PMC6265457
    Reference Link
  • 1.
    vonHoldt B, Ji S, Aardema M, Stahler D, Udell M, Sinsheimer J. Activity of Genes with Functions in Human Williams-Beuren Syndrome Is Impacted by Mobile Element Insertions in the Gray Wolf Genome. Genome Biol Evol. 2018;10(6):1546–1553. PMCID: PMC6007319
    Reference Link
  • 1.
    Morscher R, Ducker G, Li S, Mayer J, Gitai Z, Sperl W, Rabinowitz J. Mitochondrial translation requires folate-dependent tRNA methylation. Nature. 2018;554(7690):128–132. PMCID: PMC6020024
    Reference Link
  • 1.
    Asam K, Staniszewski A, Zhang H, Melideo S, Mazzeo A, Voronkov M, Huber K, Pérez E, Stock M, Stock J, Arancio O, Nicholls R. Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer’s disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid. PLoS One. 2017;12(12):e0189413. PMCID: PMC5734769
    Reference Link
  • 1.
    Park H-J, Lee K-W, Oh S, Yan R, Zhang J, Beach T, Adler C, Voronkov M, Braithwaite S, Stock J, Mouradian M. Protein Phosphatase 2A and Its Methylation Modulating Enzymes LCMT-1 and PME-1 Are Dysregulated in Tauopathies of Progressive Supranuclear Palsy and Alzheimer Disease. J Neuropathol Exp Neurol. 2018;77(2):139–148. PMCID: PMC6251692
    Reference Link
  • 1.
    Holt M, David Y, Pollock S, Tang Z, Jeon J, Kim J, Roeder R, Muir T. Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin. Proc Natl Acad Sci U S A. 2015;112(33):10365–70. PMCID: PMC4547310
    Reference Link
  • 1.
    Lu C, Jain S, Hoelper D, Bechet D, Molden R, Ran L, Murphy D, Venneti S, Hameed M, Pawel B, Wunder J, Dickson B, Lundgren S, Jani K, De Jay N, Papillon-Cavanagh S, Andrulis I, Sawyer S, Grynspan D, Turcotte R, Nadaf J, Fahiminiyah S, Muir T, Majewski J, Thompson C, Chi P, Garcia B, Allis D, Jabado N, Lewis P. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science. 2016;352(6287):844–9. PMCID: PMC4928577
    Reference Link
  • 1.
    Su X, Wellen K, Rabinowitz J. Metabolic control of methylation and acetylation. Curr Opin Chem Biol. 2016;30:52–60. PMCID: PMC4731252
    Reference Link
  • 1.
    Müller M, Fierz B, Bittova L, Liszczak G, Muir T. A two-state activation mechanism controls the histone methyltransferase Suv39h1. Nat Chem Biol. 2016;12(3):188–93. PMCID: PMC4876634
    Reference Link
  • 1.
    Zhou L, Holt M, Ohashi N, Zhao A, Müller M, Wang B, Muir T. Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation. Nat Commun. 2016;7:10589. PMCID: PMC4740876
    Reference Link
  • 1.
    DeHart C, Chahal J, Flint S, Perlman D. Extensive post-translational modification of active and inactivated forms of endogenous p53. Mol Cell Proteomics. 2014;13(1):1–17. PMCID: PMC3879606
    Reference Link
  • 1.
    Xing Y, Li Z, Chen Y, Stock J, Jeffrey P, Shi Y. Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell. 2008;133(1):154–63. PMID: 18394995
    Reference Link
  • 1.
    Basurto-Islas G, Blanchard J, Tung Y, Fernández J, Voronkov M, Stock M, Zhang S, Stock J, Iqbal K. Therapeutic benefits of a component of coffee in a rat model of Alzheimer’s disease. Neurobiol Aging. 2014;35(12):2701–2712. PMCID: PMC4254318
    Reference Link

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