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Metabolomics

  • 1.
    Hansen J, Sealfon R, Menon R, Eadon M, Lake B, Steck B, Anjani K, Parikh S, Sigdel T, Zhang G, Velickovic D, Barwinska D, Alexandrov T, Dobi D, Rashmi P, Otto E, Rivera M, Rose M, Anderton C, Shapiro J, Pamreddy A, Winfree S, Xiong Y, He Y, de Boer I, Hodgin J, Barisoni L, Naik A, Sharma K, Sarwal M, Zhang K, Himmelfarb J, Rovin B, El-Achkar T, Laszik Z, He J, Dagher P, Valerius T, Jain S, Satlin L, Troyanskaya O, Kretzler M, Iyengar R, Azeloglu E, Kidney Precision Medicine Project. A reference tissue atlas for the human kidney. Sci Adv. 2022;8(23):eabn4965. PMCID: PMC9176741
    Reference Link
  • 1.
    Covington B, Seyedsayamdost M. Guidelines for metabolomics-guided transposon mutagenesis for microbial natural product discovery. Methods Enzymol. 2022;665:305–323. PMCID: PMC9078877
    Reference Link
  • 1.
    Li X, Hui S, Mirek E, Jonsson W, Anthony T, Lee W, Zeng X, Jang C, Rabinowitz J. Circulating metabolite homeostasis achieved through mass action. Nat Metab. 2022;4(1):141–152. PMCID: PMC9244777
    Reference Link
  • 1.
    Covington B, Seyedsayamdost M. MetEx, a Metabolomics Explorer Application for Natural Product Discovery. ACS Chem Biol. 2021;16(12):2825–2833. PMCID: PMC9090437
    Reference Link
  • 1.
    Chen L, Lu W, Wang L, Xing X, Chen Z, Teng X, Zeng X, Muscarella A, Shen Y, Cowan A, McReynolds M, Kennedy B, Lato A, Campagna S, Singh M, Rabinowitz J. Metabolite discovery through global annotation of untargeted metabolomics data. Nat Methods. 2021;18(11):1377–1385. PMCID: PMC8733904
    Reference Link
  • 1.
    Bartman C, TeSlaa T, Rabinowitz J. Quantitative flux analysis in mammals. Nat Metab. 2021;3(7):896–908. PMCID: PMC9289955
    Reference Link
  • 1.
    Yoshimura A, Covington B, Gallant Étienne, Zhang C, Li A, Seyedsayamdost M. Unlocking Cryptic Metabolites with Mass Spectrometry-Guided Transposon Mutant Selection. ACS Chem Biol. 2020;15(10):2766–2774. PMCID: PMC7572862
    Reference Link
  • 1.
    Murashige D, Jang C, Neinast M, Edwards J, Cowan A, Hyman M, Rabinowitz J, Frankel D, Arany Z. Comprehensive quantification of fuel use by the failing and nonfailing human heart. Science. 2020;370(6514):364–368. PMCID: PMC7871704
    Reference Link
  • 1.
    Farag M, Hegazi N, Donia M. Molecular networking based LC/MS reveals novel biotransformation products of green coffee by ex vivo cultures of the human gut microbiome. Metabolomics. 2020;16(8):86. PMID: 32748036
    Reference Link
  • 1.
    Li A, Ducker G, Li Y, Seoane J, Xiao Y, Melemenidis S, Zhou Y, Liu L, Vanharanta S, Graves E, Rankin E, Curtis C, Massagué J, Rabinowitz J, Thompson C, Ye J. Metabolic Profiling Reveals a Dependency of Human Metastatic Breast Cancer on Mitochondrial Serine and One-Carbon Unit Metabolism. Mol Cancer Res. 2020;18(4):599–611. PMCID: PMC7127984
    Reference Link
  • 1.
    Dekhne A, Shah K, Ducker G, Katinas J, Wong-Roushar J, Nayeen M, Doshi A, Ning C, Bao X, Frühauf J, Liu J, Wallace-Povirk A, O’Connor C, Dzinic S, White K, Kushner J, Kim S, Hüttemann M, Polin L, Rabinowitz J, Li J, Hou Z, Dann C, Gangjee A, Matherly L. Novel Pyrrolo[3,2-]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy. Mol Cancer Ther. 2019;18(10):1787–1799. PMCID: PMC6774887
    Reference Link
  • 1.
    Su X, Lu W, Rabinowitz J. Metabolite Spectral Accuracy on Orbitraps. Anal Chem. 2017;89(11):5940–5948. PMCID: PMC5748891
    Reference Link
  • 1.
    Xu F, Wu Y, Zhang C, Davis K, Moon K, Bushin L, Seyedsayamdost M. A genetics-free method for high-throughput discovery of cryptic microbial metabolites. Nat Chem Biol. 2019;15(2):161–168. PMCID: PMC6339573
    Reference Link
  • 1.
    Tuttle R, Demko A, Patin N, Kapono C, Donia M, Dorrestein P, Jensen P. Detection of Natural Products and Their Producers in Ocean Sediments. Appl Environ Microbiol. 2019;85(8). PMCID: PMC6450032
    Reference Link
  • 1.
    Jang C, Chen L, Rabinowitz J. Metabolomics and Isotope Tracing. Cell. 2018;173(4):822–837. PMCID: PMC6034115
    Reference Link
  • 1.
    Okada B, Wu Y, Mao D, Bushin L, Seyedsayamdost M. Mapping the Trimethoprim-Induced Secondary Metabolome of Burkholderia thailandensis. ACS Chem Biol. 2016;11(8):2124–30. PMCID: PMC6786267
    Reference Link
  • 1.
    Zhang Y, Avalos J. Traditional and novel tools to probe the mitochondrial metabolism in health and disease. Wiley Interdiscip Rev Syst Biol Med. 2017;9(2). PMID: 28067471
    Reference Link
  • 1.
    Kim H, Raffler J, Lu W, Lee J-J, Abbey D, Saleheen D, Rabinowitz J, Bennett M, Hand N, Brown C, Rader D. Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport. Am J Hum Genet. 2017;101(4):489–502. PMCID: PMC5630162
    Reference Link
  • 1.
    Gong Y, Cao R, Ding G, Hong S, Zhou W, Lu W, Damle M, Fang B, Wang C, Qian J, Lie N, Lanzillotta C, Rabinowitz J, Sun Z. Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle. Mol Cell Endocrinol. 2018;471:22–32. PMCID: PMC5702591
    Reference Link
  • 1.
    Rajeshkumar N, Yabuuchi S, Pai S, De Oliveira E, Kamphorst J, Rabinowitz J, Tejero H, Al-Shahrour F, Hidalgo M, Maitra A, Dang C. Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin. Clin Cancer Res. 2017;23(18):5639–5647. PMCID: PMC6540110
    Reference Link
  • 1.
    Lu W, Su X, Klein M, Lewis I, Fiehn O, Rabinowitz J. Metabolite Measurement: Pitfalls to Avoid and Practices to Follow. Annu Rev Biochem. 2017;86:277–304. PMCID: PMC5734093
    Reference Link
  • 1.
    Beltran P, Federspiel J, Sheng X, Cristea I. Proteomics and integrative omic approaches for understanding host-pathogen interactions and infectious diseases. Mol Syst Biol. 2017;13(3):922. PMCID: PMC5371729
    Reference Link
  • 1.
    Teng X, Emmett M, Lazar M, Goldberg E, Rabinowitz J. Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis. ACS Chem Biol. 2016;11(9):2420–7. PMCID: PMC5317044
    Reference Link
  • 1.
    Moloughney J, Kim P, Vega-Cotto N, Wu C-C, Zhang S, Adlam M, Lynch T, Chou P-C, Rabinowitz J, Werlen G, Jacinto E. mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1. Mol Cell. 2016;63(5):811–26. PMCID: PMC5006067
    Reference Link
  • 1.
    Wilson M, Wang R, Gitai Z, Seyedsayamdost M. Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink. Proc Natl Acad Sci U S A. 2016;113(6):1630–5. PMCID: PMC4760781
    Reference Link

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