1.Wegner S, Barocio-Galindo R, Avalos J. The bright frontiers of microbial metabolic optogenetics. Curr Opin Chem Biol. 2022;71:102207. PMID: 36103753 Reference Link
1.Ghergurovich J, Xu X, Wang J, Yang L, Ryseck R-P, Wang L, Rabinowitz J. Methionine synthase supports tumour tetrahydrofolate pools. Nat Metab. 2021;3(11):1512–1520. PMCID: PMC9284419 Reference Link
1.Zhang Z, TeSlaa T, Xu X, Zeng X, Yang L, Xing G, Tesz G, Clasquin M, Rabinowitz J. Serine catabolism generates liver NADPH and supports hepatic lipogenesis. Nat Metab. 2021;3(12):1608–1620. PMCID: PMC8721747 Reference Link
1.Pareek V, Sha Z, He J, Wingreen N, Benkovic S. Metabolic channeling: predictions, deductions, and evidence. Mol Cell. 2021;81(18):3775–3785. PMCID: PMC8485759 Reference Link
1.Cable J, Pourquié O, Wellen K, Finley L, Aulehla A, Gould A, Teleman A, Tu W, Garrett W, Miguel-Aliaga I, Perrimon N, Hooper L, Walhout A, Wei W, Alexandrov T, Erez A, Ralser M, Rabinowitz J, Hemalatha A, Gutiérrez-Pérez P, Chandel N, Rutter J, Locasale J, Landoni J, Christofk H. Metabolic decisions in development and disease-a Keystone Symposia report. Ann N Y Acad Sci. 2021;1506(1):55–73. PMID: 34414571 Reference Link
1.López J, Duran L, Avalos J. Physiological limitations and opportunities in microbial metabolic engineering. Nat Rev Microbiol. 2022;20(1):35–48. PMCID: 5812522 Reference Link
1.Bartman C, TeSlaa T, Rabinowitz J. Quantitative flux analysis in mammals. Nat Metab. 2021;3(7):896–908. PMCID: PMC9289955 Reference Link
1.Zhao E, Lalwani M, Chen J-M, Orillac P, Toettcher J, Avalos J. Optogenetic Amplification Circuits for Light-Induced Metabolic Control. ACS Synth Biol. 2021;10(5):1143–1154. PMCID: PMC8721662 Reference Link
1.Lovelett R, Zhao E, Lalwani M, Toettcher J, Kevrekidis I, Avalos J. Dynamical Modeling of Optogenetic Circuits in Yeast for Metabolic Engineering Applications. ACS Synth Biol. 2021;10(2):219–227. PMID: 33492138 Reference Link
1.Carrasco-López C, García-Echauri S, Kichuk T, Avalos J. Optogenetics and biosensors set the stage for metabolic cybergenetics. Curr Opin Biotechnol. 2020;65:296–309. PMID: 32932048 Reference Link
1.Green R, Wang L, Hart S, Lu W, Skelding D, Burton J, Mi H, Capel A, Chen H, Lin A, Subramaniam A, Rabinowitz J, Shou W. Metabolic excretion associated with nutrient-growth dysregulation promotes the rapid evolution of an overt metabolic defect. PLoS Biol. 2020;18(8):e3000757. PMCID: PMC7470746 Reference Link
1.Duran L, López J, Avalos J. ¡Viva la mitochondria!: harnessing yeast mitochondria for chemical production. FEMS Yeast Res. 2020;20(6). PMID: 32592388 Reference Link
1.Song Y, Shvartsman S. Chemical Embryology Redux: Metabolic Control of Development. Trends Genet. 2020;36(8):577–586. PMID: 32532533 Reference Link
1.Diehl K, Muir T. Chromatin as a key consumer in the metabolite economy. Nat Chem Biol. 2020;16(6):620–629. PMCID: PMC7258299 Reference Link
1.Zhao E, Suek N, Wilson M, Dine E, Pannucci N, Gitai Z, Avalos J, Toettcher J. Light-based control of metabolic flux through assembly of synthetic organelles. Nat Chem Biol. 2019;15(6):589–597. PMCID: PMC6755918 Reference Link
1.Trivedi R, Crooks J, Auer G, Pendry J, Foik I, Siryaporn A, Abbott N, Gitai Z, Weibel D. Mechanical Genomic Studies Reveal the Role of d-Alanine Metabolism in Pseudomonas aeruginosa Cell Stiffness. mBio. 2018;9(5). PMCID: PMC6134093 Reference Link
1.Zhao E, Zhang Y, Mehl J, Park H, Lalwani M, Toettcher J, Avalos J. Optogenetic regulation of engineered cellular metabolism for microbial chemical production. Nature. 2018;555(7698):683–687. PMCID: PMC5876151 Reference Link
1.Watson E, Olin-Sandoval V, Hoy M, Li C-H, Louisse T, Yao V, Mori A, Holdorf A, Troyanskaya O, Ralser M, Walhout A. Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans. Elife. 2016;5. PMCID: PMC4951191 Reference Link
1.Rajeshkumar N, Yabuuchi S, Pai S, De Oliveira E, Kamphorst J, Rabinowitz J, Tejero H, Al-Shahrour F, Hidalgo M, Maitra A, Dang C. Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin. Clin Cancer Res. 2017;23(18):5639–5647. PMCID: PMC6540110 Reference Link
1.Okuda S, Sherman D, Silhavy T, Ruiz N, Kahne D. Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model. Nat Rev Microbiol. 2016;14(6):337–45. PMCID: PMC4937791 Reference Link
1.Ron-Harel N, Santos D, Ghergurovich J, Sage P, Reddy A, Lovitch S, Dephoure N, Satterstrom K, Sheffer M, Spinelli J, Gygi S, Rabinowitz J, Sharpe A, Haigis M. Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metab. 2016;24(1):104–17. PMCID: PMC5330619 Reference Link
1.Hackett S, Zanotelli V, Xu W, Goya J, Park J, Perlman D, Gibney P, Botstein D, Storey J, Rabinowitz J. Systems-level analysis of mechanisms regulating yeast metabolic flux. Science. 2016;354(6311). PMCID: PMC5414049 Reference Link
1.Ducker G, Chen L, Morscher R, Ghergurovich J, Esposito M, Teng X, Kang Y, Rabinowitz J. Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway. Cell Metab. 2016;23(6):1140–1153. PMCID: PMC4909566 Reference Link
1.Budayeva H, Rowland E, Cristea I. Intricate Roles of Mammalian Sirtuins in Defense against Viral Pathogens. J Virol. 2016;90(1):5–8. PMCID: PMC4702534 Reference Link
1.Adolfsen K, Brynildsen M. A Kinetic Platform to Determine the Fate of Hydrogen Peroxide in Escherichia coli. PLoS Comput Biol. 2015;11(11):e1004562. PMCID: PMC4636272 Reference Link
1.Ducker G, Rabinowitz J. One-Carbon Metabolism in Health and Disease. Cell Metab. 2017;25(1):27–42. PMCID: PMC5353360 Reference Link
1.Avalos J, Fink G, Stephanopoulos G. Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols. Nat Biotechnol. 2013;31(4):335–41. PMCID: PMC3659820 Reference Link
