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Metabolic Engineering

  • 1.
    Wegner S, Barocio-Galindo R, Avalos J. The bright frontiers of microbial metabolic optogenetics. Curr Opin Chem Biol. 2022;71:102207. PMID: 36103753
    Reference Link
  • 1.
    Hoffman S, Lalwani M, Avalos J. Light-Controlled Fermentations for Microbial Chemical and Protein Production. J Vis Exp. 2022;(181). PMID: 35404352
    Reference Link
  • 1.
    Zhang Y, Cortez J, Hammer S, Carrasco-López C, Echauri S, Wiggins J, Wang W, Avalos J. Biosensor for branched-chain amino acid metabolism in yeast and applications in isobutanol and isopentanol production. Nat Commun. 2022;13(1):270. PMCID: PMC8755756
    Reference Link
  • 1.
    Wegner S, Chen J-M, Ip S, Zhang Y, Dugar D, Avalos J. Engineering acetyl-CoA supply and ERG9 repression to enhance mevalonate production in Saccharomyces cerevisiae. J Ind Microbiol Biotechnol. 2021;48(9-10). PMCID: PMC8788843
    Reference Link
  • 1.
    Lalwani M, Kawabe H, Mays R, Hoffman S, Avalos J. Optogenetic Control of Microbial Consortia Populations for Chemical Production. ACS Synth Biol. 2021;10(8):2015–2029. PMID: 34351122
    Reference Link
  • 1.
    Lalwani M, Zhao E, Wegner S, Avalos J. The Inducible Q System Enables Simultaneous Optogenetic Amplification and Inversion in for Bidirectional Control of Gene Expression. ACS Synth Biol. 2021;10(8):2060–2075. PMID: 34346207
    Reference Link
  • 1.
    López J, Duran L, Avalos J. Physiological limitations and opportunities in microbial metabolic engineering. Nat Rev Microbiol. 2022;20(1):35–48. PMCID: 5812522
    Reference Link
  • 1.
    Zhao E, Lalwani M, Chen J-M, Orillac P, Toettcher J, Avalos J. Optogenetic Amplification Circuits for Light-Induced Metabolic Control. ACS Synth Biol. 2021;10(5):1143–1154. PMCID: PMC8721662
    Reference Link
  • 1.
    Lovelett R, Zhao E, Lalwani M, Toettcher J, Kevrekidis I, Avalos J. Dynamical Modeling of Optogenetic Circuits in Yeast for Metabolic Engineering Applications. ACS Synth Biol. 2021;10(2):219–227. PMID: 33492138
    Reference Link
  • 1.
    Zhao E, Lalwani M, Lovelett R, García-Echauri S, Hoffman S, Gonzalez C, Toettcher J, Kevrekidis I, Avalos J. Design and Characterization of Rapid Optogenetic Circuits for Dynamic Control in Yeast Metabolic Engineering. ACS Synth Biol. 2020;9(12):3254–3266. PMID: 33232598
    Reference Link
  • 1.
    Carrasco-López C, García-Echauri S, Kichuk T, Avalos J. Optogenetics and biosensors set the stage for metabolic cybergenetics. Curr Opin Biotechnol. 2020;65:296–309. PMID: 32932048
    Reference Link
  • 1.
    Lalwani M, Ip S, Carrasco-López C, Day C, Zhao E, Kawabe H, Avalos J. Optogenetic control of the lac operon for bacterial chemical and protein production. Nat Chem Biol. 2021;17(1):71–79. PMCID: 5876151
    Reference Link
  • 1.
    Duran L, López J, Avalos J. ¡Viva la mitochondria!: harnessing yeast mitochondria for chemical production. FEMS Yeast Res. 2020;20(6). PMID: 32592388
    Reference Link
  • 1.
    Zhang Y, Kleiner R. A Metabolic Engineering Approach to Incorporate Modified Pyrimidine Nucleosides into Cellular RNA. J Am Chem Soc. 2019;141(8):3347–3351. PMID: 30735369
    Reference Link
  • 1.
    Hammer S, Zhang Y, Avalos J. Mitochondrial Compartmentalization Confers Specificity to the 2-Ketoacid Recursive Pathway: Increasing Isopentanol Production in . ACS Synth Biol. 2020;9(3):546–555. PMID: 32049515
    Reference Link
  • 1.
    Lane S, Zhang Y, Yun E, Ziolkowski L, Zhang G, Jin Y-S, Avalos J. Xylose assimilation enhances the production of isobutanol in engineered Saccharomyces cerevisiae. Biotechnol Bioeng. 2020;117(2):372–381. PMID: 31631318
    Reference Link
  • 1.
    Zhao E, Suek N, Wilson M, Dine E, Pannucci N, Gitai Z, Avalos J, Toettcher J. Light-based control of metabolic flux through assembly of synthetic organelles. Nat Chem Biol. 2019;15(6):589–597. PMCID: PMC6755918
    Reference Link
  • 1.
    Brynildsen M. Nitric Oxide Stress as a Metabolic Flux. Adv Microb Physiol. 2018;73:63–76. PMID: 30262110
    Reference Link
  • 1.
    Hammer S, Avalos J. Metabolic engineering: Biosensors get the green light. Nat Chem Biol. 2016;12(11):894–895. PMID: 27755525
    Reference Link
  • 1.
    Hammer S, Avalos J. Harnessing yeast organelles for metabolic engineering. Nat Chem Biol. 2017;13(8):823–832. PMID: 28853733
    Reference Link
  • 1.
    Zhao E, Zhang Y, Mehl J, Park H, Lalwani M, Toettcher J, Avalos J. Optogenetic regulation of engineered cellular metabolism for microbial chemical production. Nature. 2018;555(7698):683–687. PMCID: PMC5876151
    Reference Link
  • 1.
    Lalwani M, Zhao E, Avalos J. Current and future modalities of dynamic control in metabolic engineering. Curr Opin Biotechnol. 2018;52:56–65. PMID: 29574344
    Reference Link
  • 1.
    Watson E, Olin-Sandoval V, Hoy M, Li C-H, Louisse T, Yao V, Mori A, Holdorf A, Troyanskaya O, Ralser M, Walhout A. Metabolic network rewiring of propionate flux compensates vitamin B12 deficiency in C. elegans. Elife. 2016;5. PMCID: PMC4951191
    Reference Link

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