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Membrane Proteins

  • 1.
    Chen H, Zhan M, Liu J, Liu Z, Shen M, Yang F, Kang Y, Yin F, Li Z. Structure-Based Design, Optimization, and Evaluation of Potent Stabilized Peptide Inhibitors Disrupting MTDH and SND1 Interaction. J Med Chem. 2022;65(18):12188–12199. PMID: 36044768
    Reference Link
  • 1.
    Zhao A, Bodine S, Xie Q, Wang B, Ram G, Novick R, Muir T. Reconstitution of the quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesis. Proc Natl Acad Sci U S A. 2022;119(33):e2202661119. PMCID: PMC9388083
    Reference Link
  • 1.
    Buksh B, Knutson S, Oakley J, Bissonnette N, Oblinsky D, Schwoerer M, Seath C, Geri J, Rodriguez-Rivera F, Parker D, Scholes G, Ploss A, MacMillan D. μMap-Red: Proximity Labeling by Red Light Photocatalysis. J Am Chem Soc. 2022;144(14):6154–6162. PMCID: PMC9843638
    Reference Link
  • 1.
    Klibaite U, Kislin M, Verpeut J, Bergeler S, Sun X, Shaevitz J, Wang S. Deep phenotyping reveals movement phenotypes in mouse neurodevelopmental models. Mol Autism. 2022;13(1):12. PMCID: PMC8917660
    Reference Link
  • 1.
    Shen M, Wei Y, Kim H, Wan L, Jiang Y-Z, Hang X, Raba M, Remiszewski S, Rowicki M, Wu C-G, Wu S, Zhang L, Lu X, Yuan M, Smith H, Zheng A, Bertino J, Jin J, Xing Y, Shao Z-M, Kang Y. Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis. Nat Cancer. 2022;3(1):43–59. PMCID: PMC8818087
    Reference Link
  • 1.
    Shen M, Smith H, Wei Y, Jiang Y-Z, Zhao S, Wang N, Rowicki M, Tang Y, Hang X, Wu S, Wan L, Shao Z-M, Kang Y. Pharmacological disruption of the MTDH-SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer. Nat Cancer. 2022;3(1):60–74. PMCID: PMC8818088
    Reference Link
  • 1.
    Wu X, Yan R, Cao P, Qian H, Yan N. Structural advances in sterol-sensing domain-containing proteins. Trends Biochem Sci. 2022;47(4):289–300. PMID: 35012873
    Reference Link
  • 1.
    Kumar S, Nandi A, Singh S, Regulapati R, Li N, Tobias J, Siebel C, Blanco M, Klein-Szanto A, Lengner C, Welm A, Kang Y, Chakrabarti R. Dll1 quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway. Nat Commun. 2021;12(1):432. PMCID: PMC7813834
    Reference Link
  • 1.
    Basta L, Hill-Oliva M, Paramore S, Sharan R, Goh A, Biswas A, Cortez M, Little K, Posfai E, Devenport D. New mouse models for high resolution and live imaging of planar cell polarity proteins in vivo. Development. 2021;148(18). PMCID: PMC8487645
    Reference Link
  • 1.
    Landajuela A, Braun M, Rodrigues C, Martínez-Calvo A, Doan T, Horenkamp F, Andronicos A, Shteyn V, Williams N, Lin C, Wingreen N, Rudner D, Karatekin E. FisB relies on homo-oligomerization and lipid binding to catalyze membrane fission in bacteria. PLoS Biol. 2021;19(6):e3001314. PMCID: PMC8274934
    Reference Link
  • 1.
    Dine E, Reed E, Toettcher J. Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch. Cell Rep. 2021;35(12):109280. PMCID: PMC8292983
    Reference Link
  • 1.
    Yan R, Cao P, Song W, Li Y, Wang T, Qian H, Yan C, Yan N. Structural basis for sterol sensing by Scap and Insig. Cell Rep. 2021;35(13):109299. PMID: 34192549
    Reference Link
  • 1.
    Yan R, Cao P, Song W, Qian H, Du X, Coates H, Zhao X, Li Y, Gao S, Gong X, Liu X, Sui J, Lei J, Yang H, Brown A, Zhou Q, Yan C, Yan N. A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. Science. 2021;371(6533). PMID: 33446483
    Reference Link
  • 1.
    Shen M, Xie S, Rowicki M, Michel S, Wei Y, Hang X, Wan L, Lu X, Yuan M, Jin J, Jaschinski F, Zhou T, Klar R, Kang Y. Therapeutic Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis. Cancer Res. 2021;81(4):1014–1025. PMCID: PMC8026491
    Reference Link
  • 1.
    Grimm J, Shi H, Wang W, Mitchell A, Wingreen N, Huang K, Silhavy T. The inner membrane protein YhdP modulates the rate of anterograde phospholipid flow in . Proc Natl Acad Sci U S A. 2020;117(43):26907–26914. PMCID: PMC7604412
    Reference Link
  • 1.
    Kaletsky R, Moore R, Vrla G, Parsons L, Gitai Z, Murphy C. C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance. Nature. 2020;586(7829):445–451. PMCID: PMC8547118
    Reference Link
  • 1.
    Yao X, Fan X, Yan N. Cryo-EM analysis of a membrane protein embedded in the liposome. Proc Natl Acad Sci U S A. 2020;117(31):18497–18503. PMCID: PMC7414195
    Reference Link
  • 1.
    Guest R, Guerra D, Wissler M, Grimm J, Silhavy T. YejM Modulates Activity of the YciM/FtsH Protease Complex To Prevent Lethal Accumulation of Lipopolysaccharide. mBio. 2020;11(2). PMCID: PMC7157816
    Reference Link
  • 1.
    Brose N, Brunger A, Cafiso D, Chapman E, Diao J, Hughson F, Jackson M, Jahn R, Lindau M, Ma C, Rizo J, Shin Y-K, Söllner T, Tamm L, Yoon T-Y, Zhang Y. Synaptic vesicle fusion: today and beyond. Nat Struct Mol Biol. 2019;26(8):663–668. PMID: 31384060
    Reference Link
  • 1.
    Bialistoky T, Manry D, Smith P, Ng C, Kim Y, Zamir S, Moyal V, Kalifa R, Schedl P, Gerlitz O, Deshpande G. Functional analysis of Niemann-Pick disease type C family protein, NPC1a, in . Development. 2019;146(10). PMCID: PMC6550021
    Reference Link
  • 1.
    Yan R, Qian H, Lukmantara I, Gao M, Du X, Yan N, Yang H. Human SEIPIN Binds Anionic Phospholipids. Dev Cell. 2018;47(2):248–256.e4. PMID: 30293840
    Reference Link
  • 1.
    Mitchell A, Srikumar T, Silhavy T. Cyclic Enterobacterial Common Antigen Maintains the Outer Membrane Permeability Barrier of Escherichia coli in a Manner Controlled by YhdP. mBio. 2018;9(4). PMCID: PMC6083912
    Reference Link
  • 1.
    Konovalova A, Grabowicz M, Balibar C, Malinverni J, Painter R, Riley D, Mann P, Wang H, Garlisi C, Sherborne B, Rigel N, Ricci D, Black T, Roemer T, Silhavy T, Walker S. Inhibitor of intramembrane protease RseP blocks the σ response causing lethal accumulation of unfolded outer membrane proteins. Proc Natl Acad Sci U S A. 2018;115(28):E6614-E6621. PMCID: PMC6048503
    Reference Link
  • 1.
    Ding Q, Gaska J, Douam F, Wei L, Kim D, Balev M, Heller B, Ploss A. Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease. Proc Natl Acad Sci U S A. 2018;115(27):E6310-E6318. PMCID: PMC6142274
    Reference Link
  • 1.
    Dine E, Gil A, Uribe G, Brangwynne C, Toettcher J. Protein Phase Separation Provides Long-Term Memory of Transient Spatial Stimuli. Cell Syst. 2018;6(6):655–663.e5. PMCID: PMC6023754
    Reference Link
  • 1.
    Camberg J, Sandkvist M. Molecular analysis of the Vibrio cholerae type II secretion ATPase EpsE. J Bacteriol. 2005;187(1):249–56. PMCID: PMC538811
    Reference Link
  • 1.
    He Y, Wang K, Yan N. The recombinant expression systems for structure determination of eukaryotic membrane proteins. Protein Cell. 2014;5(9):658–72. PMCID: PMC4145085
    Reference Link
  • 1.
    Ren R, Zhou X, He Y, Ke M, Wu J, Liu X, Yan C, Wu Y, Gong X, Lei X, Yan F, Radhakrishnan A, Yan N. PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels. Science. 2015;349(6244):187–91. PMCID: PMC4704858
    Reference Link
  • 1.
    Gong X, Qian H, Shao W, Li J, Wu J, Liu J-J, Li W, Wang H-W, Espenshade P, Yan N. Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization. Cell Res. 2016;26(11):1197–1211. PMCID: PMC5099872
    Reference Link
  • 1.
    Smith J, Hall A, Rose M. Membrane curvature directs the localization of Cdc42p to novel foci required for cell-cell fusion. J Cell Biol. 2017;216(12):3971–3980. PMCID: PMC5716282
    Reference Link
  • 1.
    Tenenbaum C, Misra M, Alizzi R, Gavis E. Enclosure of Dendrites by Epidermal Cells Restricts Branching and Permits Coordinated Development of Spatially Overlapping Sensory Neurons. Cell Rep. 2017;20(13):3043–3056. PMCID: PMC5662031
    Reference Link
  • 1.
    Cetera M, Leybova L, Woo F, Deans M, Devenport D. Planar cell polarity-dependent and independent functions in the emergence of tissue-scale hair follicle patterns. Dev Biol. 2017;428(1):188–203. PMCID: PMC5549468
    Reference Link
  • 1.
    Sacco S, Adolfsen K, Brynildsen M. An integrated network analysis identifies how ArcAB enables metabolic oscillations in the nitric oxide detoxification network of Escherichia coli. Biotechnol J. 2017;12(8). PMID: 28449226
    Reference Link
  • 1.
    Rogers W, Goyal Y, Yamaya K, Shvartsman S, Levine M. Uncoupling neurogenic gene networks in the embryo. Genes Dev. 2017;31(7):634–638. PMCID: PMC5411704
    Reference Link
  • 1.
    Devergne O, Sun G, Schüpbach T. Stratum, a Homolog of the Human GEF Mss4, Partnered with Rab8, Controls the Basal Restriction of Basement Membrane Proteins in Epithelial Cells. Cell Rep. 2017;18(8):1831–1839. PMCID: PMC5693311
    Reference Link
  • 1.
    Weng M, Wieschaus E. Polarity protein Par3/Bazooka follows myosin-dependent junction repositioning. Dev Biol. 2017;422(2):125–134. PMCID: PMC5515594
    Reference Link
  • 1.
    Cope E, Briones B, Brockett A, Martinez S, Vigneron P-A, Opendak M, Wang S, Gould E. Immature Neurons and Radial Glia, But Not Astrocytes or Microglia, Are Altered in Adult Cntnap2 and Shank3 Mice, Models of Autism. eNeuro. 2016;3(5). PMCID: PMC5066262
    Reference Link
  • 1.
    Christensen M, Jensen S, Miettinen J, Luecke S, Prabakaran T, Reinert L, Mettenleiter T, Chen Z, Knipe D, Sandri-Goldin R, Enquist L, Hartmann R, Mogensen T, Rice S, Nyman T, Matikainen S, Paludan S. HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression. EMBO J. 2016;35(13):1385–99. PMCID: PMC4931188
    Reference Link
  • 1.
    Jonikas M, Collins S, Denic V, Oh E, Quan E, Schmid V, Weibezahn J, Schwappach B, Walter P, Weissman J, Schuldiner M. Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science. 2009;323(5922):1693–7. PMCID: PMC2877488
    Reference Link
  • 1.
    Berezhkovskii A, Shvartsman S. Dynamics of gradient formation by intracellular shuttling. J Chem Phys. 2015;143(7):074116. PMCID: PMC5562396
    Reference Link
  • 1.
    Baker R, Jeffrey P, Zick M, Phillips B, Wickner W, Hughson F. A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly. Science. 2015;349(6252):1111–4. PMCID: PMC4727825
    Reference Link
  • 1.
    Bednarz-Knoll N, Efstathiou A, Gotzhein F, Wikman H, Mueller V, Kang Y, Pantel K. Potential Involvement of Jagged1 in Metastatic Progression of Human Breast Carcinomas. Clin Chem. 2016;62(2):378–86. PMID: 26721293
    Reference Link
  • 1.
    Korennykh A, Walter P. Structural basis of the unfolded protein response. Annu Rev Cell Dev Biol. 2012;28:251–77. PMID: 23057742
    Reference Link
  • 1.
    Rogers J, Rose M. Kar5p is required for multiple functions in both inner and outer nuclear envelope fusion in Saccharomyces cerevisiae. G3 (Bethesda). 2014;5(1):111–21. PMCID: PMC4291462
    Reference Link
  • 1.
    Stein R, Smith J, Rose M. An Amphiphysin-Like Domain in Fus2p Is Required for Rvs161p Interaction and Cortical Localization. G3 (Bethesda). 2015;6(2):337–49. PMCID: PMC4751553
    Reference Link
  • 1.
    Smith J, Rose M. Kel1p Mediates Yeast Cell Fusion Through a Fus2p- and Cdc42p-Dependent Mechanism. Genetics. 2016;202(4):1421–35. PMCID: PMC4905532
    Reference Link
  • 1.
    Jaffe K, Grimes D, Schottenfeld-Roames J, Werner M, Ku T-S, Kim S, Pelliccia J, Morante N, Mitchell B, Burdine R. c21orf59/kurly Controls Both Cilia Motility and Polarization. Cell Rep. 2016;14(8):1841–9. PMCID: PMC4775428
    Reference Link
  • 1.
    Rader B, Campagna S, Semmelhack M, Bassler B, Guillemin K. The quorum-sensing molecule autoinducer 2 regulates motility and flagellar morphogenesis in Helicobacter pylori. J Bacteriol. 2007;189(17):6109–17. PMCID: PMC1951907
    Reference Link
  • 1.
    Ng W-L, Wei Y, Perez L, Cong J, Long T, Koch M, Semmelhack M, Wingreen N, Bassler B. Probing bacterial transmembrane histidine kinase receptor-ligand interactions with natural and synthetic molecules. Proc Natl Acad Sci U S A. 2010;107(12):5575–80. PMCID: PMC2851778
    Reference Link
  • 1.
    Ke X, Miller L, Ng W-L, Bassler B. CqsA-CqsS quorum-sensing signal-receptor specificity in Photobacterium angustum. Mol Microbiol. 2014;91(4):821–33. PMCID: PMC3959898
    Reference Link

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