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Liver

  • 1.
    Lim A, Li Y, Lopez-Lastra S, Stadhouders R, Paul F, Casrouge A, Serafini N, Puel A, Bustamante J, Surace L, Masse-Ranson G, David E, Strick-Marchand H, Le Bourhis L, Cocchi R, Topazio D, Graziano P, Muscarella L, Rogge L, Norel X, Sallenave J-M, Allez M, Graf T, Hendriks R, Casanova J-L, Amit I, Yssel H, Di Santo J. Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation. Cell. 2017;168(6):1086–1100.e10. PMID: 28283063
    Reference Link
  • 1.
    Zhang Z, TeSlaa T, Xu X, Zeng X, Yang L, Xing G, Tesz G, Clasquin M, Rabinowitz J. Serine catabolism generates liver NADPH and supports hepatic lipogenesis. Nat Metab. 2021;3(12):1608–1620. PMCID: PMC8721747
    Reference Link
  • 1.
    Chen L, Lu W, Wang L, Xing X, Chen Z, Teng X, Zeng X, Muscarella A, Shen Y, Cowan A, McReynolds M, Kennedy B, Lato A, Campagna S, Singh M, Rabinowitz J. Metabolite discovery through global annotation of untargeted metabolomics data. Nat Methods. 2021;18(11):1377–1385. PMCID: PMC8733904
    Reference Link
  • 1.
    Yu D, Richardson N, Green C, Spicer A, Murphy M, Flores V, Jang C, Kasza I, Nikodemova M, Wakai M, Tomasiewicz J, Yang S, Miller B, Pak H, Brinkman J, Rojas J, Quinn W, Cheng E, Konon E, Haider L, Finke M, Sonsalla M, Alexander C, Rabinowitz J, Baur J, Malecki K, Lamming D. The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine. Cell Metab. 2021;33(5):905–922.e6. PMCID: PMC8102360
    Reference Link
  • 1.
    Ploss A, Strick-Marchand H, Li W. Animal Models for Hepatitis B: Does the Supply Meet the Demand?. Gastroenterology. 2021;160(5):1437–1442. PMCID: PMC8035324
    Reference Link
  • 1.
    Chini C, Peclat T, Warner G, Kashyap S, Espindola-Netto J, de Oliveira G, Gomez L, Hogan K, Tarragó M, Puranik A, Agorrody G, Thompson K, Dang K, Clarke S, Childs B, Kanamori K, Witte M, Vidal P, Kirkland A, De Cecco M, Chellappa K, McReynolds M, Jankowski C, Tchkonia T, Kirkland J, Sedivy J, van Deursen J, Baker D, van Schooten W, Rabinowitz J, Baur J, Chini E. CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD and NMN levels. Nat Metab. 2020;2(11):1284–1304. PMCID: PMC8752031
    Reference Link
  • 1.
    Guan D, Xiong Y, Trinh T, Xiao Y, Hu W, Jiang C, Dierickx P, Jang C, Rabinowitz J, Lazar M. The hepatocyte clock and feeding control chronophysiology of multiple liver cell types. Science. 2020;369(6509):1388–1394. PMCID: PMC7849028
    Reference Link
  • 1.
    Zhao S, Jang C, Liu J, Uehara K, Gilbert M, Izzo L, Zeng X, Trefely S, Fernandez S, Carrer A, Miller K, Schug Z, Snyder N, Gade T, Titchenell P, Rabinowitz J, Wellen K. Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate. Nature. 2020;579(7800):586–591. PMCID: PMC7416516
    Reference Link
  • 1.
    Winer B, Edgel K, Zou X, Sellau J, Hadiwidjojo S, Garver L, McDonough C, Kelleher N, Thomas P, Villasante E, Ploss A, Gerbasi V. Identification of Plasmodium falciparum proteoforms from liver stage models. Malar J. 2020;19(1):10. PMCID: PMC6947969
    Reference Link
  • 1.
    Jang C, Hui S, Zeng X, Cowan A, Wang L, Chen L, Morscher R, Reyes J, Frezza C, Hwang H, Imai A, Saito Y, Okamoto K, Vaspoli C, Kasprenski L, Zsido G, Gorman J, Gorman R, Rabinowitz J. Metabolite Exchange between Mammalian Organs Quantified in Pigs. Cell Metab. 2019;30(3):594–606.e3. PMCID: PMC6726553
    Reference Link
  • 1.
    Poillet-Perez L, Xie X, Zhan L, Yang Y, Sharp D, Hu Z, Su X, Maganti A, Jiang C, Lu W, Zheng H, Bosenberg M, Mehnert J, Guo J, Lattime E, Rabinowitz J, White E. Autophagy maintains tumour growth through circulating arginine. Nature. 2018;563(7732):569–573. PMCID: PMC6287937
    Reference Link
  • 1.
    Neinast M, Jang C, Hui S, Murashige D, Chu Q, Morscher R, Li X, Zhan L, White E, Anthony T, Rabinowitz J, Arany Z. Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids. Cell Metab. 2019;29(2):417–429.e4. PMCID: PMC6365191
    Reference Link
  • 1.
    Gaska J, Ding Q, Ploss A. Mouse Models for Studying HCV Vaccines and Therapeutic Antibodies. Methods Mol Biol. 2019;1911:481–503. PMCID: PMC6699619
    Reference Link
  • 1.
    Guan D, Xiong Y, Borck P, Jang C, Doulias P-T, Papazyan R, Fang B, Jiang C, Zhang Y, Briggs E, Hu W, Steger D, Ischiropoulos H, Rabinowitz J, Lazar M. Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes. Cell. 2018;174(4):831–842.e12. PMCID: PMC6086765
    Reference Link
  • 1.
    Liu L, Su X, Quinn W, Hui S, Krukenberg K, Frederick D, Redpath P, Zhan L, Chellappa K, White E, Migaud M, Mitchison T, Baur J, Rabinowitz J. Quantitative Analysis of NAD Synthesis-Breakdown Fluxes. Cell Metab. 2018;27(5):1067–1080.e5. PMCID: PMC5932087
    Reference Link
  • 1.
    Dragovic S, Agunbiade T, Freudzon M, Yang J, Hastings A, Schleicher T, Zhou X, Craft S, Chuang Y-M, Gonzalez F, Li Y, Hrebikova G, Tripathi A, Mlambo G, Almeras L, Ploss A, Dimopoulos G, Fikrig E. Immunization with AgTRIO, a Protein in Anopheles Saliva, Contributes to Protection against Plasmodium Infection in Mice. Cell Host Microbe. 2018;23(4):523–535.e5. PMCID: PMC5998332
    Reference Link
  • 1.
    Miller R, Shi Y, Lu W, Pirman D, Jatkar A, Blatnik M, Wu H, Cárdenas C, Wan M, Foskett K, Park J, Zhang Y, Holland W, Rabinowitz J, Birnbaum M. Targeting hepatic glutaminase activity to ameliorate hyperglycemia. Nat Med. 2018;24(4):518–524. PMCID: PMC6089616
    Reference Link
  • 1.
    Jang C, Hui S, Lu W, Cowan A, Morscher R, Lee G, Liu W, Tesz G, Birnbaum M, Rabinowitz J. The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. Cell Metab. 2018;27(2):351–361.e3. PMCID: PMC6032988
    Reference Link
  • 1.
    Kim H, Raffler J, Lu W, Lee J-J, Abbey D, Saleheen D, Rabinowitz J, Bennett M, Hand N, Brown C, Rader D. Fine Mapping and Functional Analysis Reveal a Role of SLC22A1 in Acylcarnitine Transport. Am J Hum Genet. 2017;101(4):489–502. PMCID: PMC5630162
    Reference Link
  • 1.
    Lu W, Wang L, Chen L, Hui S, Rabinowitz J. Extraction and Quantitation of Nicotinamide Adenine Dinucleotide Redox Cofactors. Antioxid Redox Signal. 2018;28(3):167–179. PMCID: PMC5737638
    Reference Link
  • 1.
    Li D, Wang X, von Schaewen M, Tao W, Zhang Y, Heller B, Hrebikova G, Deng Q, Sun Q, Ploss A, Zhong J, Huang Z. Immunization With a Subunit Hepatitis C Virus Vaccine Elicits Pan-Genotypic Neutralizing Antibodies and Intrahepatic T-Cell Responses in Nonhuman Primates. J Infect Dis. 2017;215(12):1824–1831. PMCID: PMC5853543
    Reference Link
  • 1.
    Titchenell P, Quinn W, Lu M, Chu Q, Lu W, Li C, Chen H, Monks B, Chen J, Rabinowitz J, Birnbaum M. Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production. Cell Metab. 2016;23(6):1154–1166. PMCID: PMC4909537
    Reference Link
  • 1.
    Papazyan R, Sun Z, Kim Y, Titchenell P, Hill D, Lu W, Damle M, Wan M, Zhang Y, Briggs E, Rabinowitz J, Lazar M. Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. Cell Metab. 2016;24(6):863–874. PMCID: PMC5159233
    Reference Link
  • 1.
    Winer B, Huang T, Low B, Avery C, Pais M-A, Hrebikova G, Siu E, Chiriboga L, Wiles M, Ploss A. Recapitulation of treatment response patterns in a novel humanized mouse model for chronic hepatitis B virus infection. Virology. 2017;502:63–72. PMCID: PMC5414730
    Reference Link
  • 1.
    von Schaewen M, Hrebikova G, Ploss A. Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens. Methods Mol Biol. 2016;1438:79–101. PMID: 27150085
    Reference Link

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