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Insulin

  • 1.
    Wang N, Zhang S, Yuan Y, Xu H, Defossa E, Matter H, Besenius M, Derdau V, Dreyer M, Halland N, He K, Petry S, Podeschwa M, Tennagels N, Jiang X, Yan N. Molecular basis for inhibiting human glucose transporters by exofacial inhibitors. Nat Commun. 2022;13(1):2632. PMCID: PMC9098912
    Reference Link
  • 1.
    Yuan Y, Kong F, Xu H, Zhu A, Yan N, Yan C. Cryo-EM structure of human glucose transporter GLUT4. Nat Commun. 2022;13(1):2671. PMCID: PMC9106701
    Reference Link
  • 1.
    Lee Y, Jung Y, Jeong D-E, Hwang W, Ham S, Park H-E, Kwon S, Ashraf J, Murphy C, Lee S-J. Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP-mediated feedforward loop. J Cell Biol. 2021;220(5). PMCID: PMC7941181
    Reference Link
  • 1.
    Heimbucher T, Hog J, Gupta P, Murphy C. PQM-1 controls hypoxic survival via regulation of lipid metabolism. Nat Commun. 2020;11(1):4627. PMCID: PMC7532158
    Reference Link
  • 1.
    Murphy C. Short and sweet. Elife. 2020;9. PMCID: PMC7041940
    Reference Link
  • 1.
    Shi C, Booth L, Murphy C. Insulin-like peptides and the mTOR-TFEB pathway protect hermaphrodites from mating-induced death. Elife. 2019;8. PMCID: PMC6697448
    Reference Link
  • 1.
    Neinast M, Jang C, Hui S, Murashige D, Chu Q, Morscher R, Li X, Zhan L, White E, Anthony T, Rabinowitz J, Arany Z. Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids. Cell Metab. 2019;29(2):417–429.e4. PMCID: PMC6365191
    Reference Link
  • 1.
    Kaletsky R, Yao V, Williams A, Runnels A, Tadych A, Zhou S, Troyanskaya O, Murphy C. Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression. PLoS Genet. 2018;14(8):e1007559. PMCID: PMC6105014
    Reference Link
  • 1.
    Templeman N, Luo S, Kaletsky R, Shi C, Ashraf J, Keyes W, Murphy C. Insulin Signaling Regulates Oocyte Quality Maintenance with Age via Cathepsin B Activity. Curr Biol. 2018;28(5):753–760.e4. PMCID: PMC5893159
    Reference Link
  • 1.
    Son H, Seo M, Ham S, Hwang W, Lee D, An S, Artan M, Seo K, Kaletsky R, Arey R, Ryu Y, Ha C, Kim Y, Murphy C, Roh T-Y, Nam H, Lee S-J. RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans. Nat Commun. 2017;8:14749. PMCID: PMC5347137
    Reference Link
  • 1.
    Titchenell P, Quinn W, Lu M, Chu Q, Lu W, Li C, Chen H, Monks B, Chen J, Rabinowitz J, Birnbaum M. Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production. Cell Metab. 2016;23(6):1154–1166. PMCID: PMC4909537
    Reference Link
  • 1.
    Hahm J-H, Kim S, DiLoreto R, Shi C, Lee S-J, Murphy C, Nam H. C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation. Nat Commun. 2015;6:8919. PMCID: PMC4656132
    Reference Link
  • 1.
    DiLoreto R, Murphy C. The cell biology of aging. Mol Biol Cell. 2015;26(25):4524–31. PMCID: PMC4678010
    Reference Link
  • 1.
    Jang C, Oh S, Wada S, Rowe G, Liu L, Chan M, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca L, Kim E, Ghosh C, Parikh S, Jiang A, Chu Q, Forman D, Lecker S, Krishnaiah S, Rabinowitz J, Weljie A, Baur J, Kasper D, Arany Z. A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat Med. 2016;22(4):421–6. PMCID: PMC4949205
    Reference Link
  • 1.
    Kaletsky R, Lakhina V, Arey R, Williams A, Landis J, Ashraf J, Murphy C. The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators. Nature. 2016;529(7584):92–6. PMCID: PMC4708089
    Reference Link
  • 1.
    Li L-B, Lei H, Arey R, Li P, Liu J, Murphy C, Xu X, Shen K. The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory. Curr Biol. 2016;26(5):605–15. PMCID: PMC4783184
    Reference Link

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