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Immunity, Innate

  • 1.
    Sauerwald N, Zhang Z, Ramos I, Nair V, Soares-Schanoski A, Ge Y, Mao W, Alshammary H, Gonzalez-Reiche A, van de Guchte A, Goforth C, Lizewski R, Lizewski S, Amper M, Vasoya M, Seenarine N, Guevara K, Marjanovic N, Miller C, Nudelman G, Schilling M, Sealfon R, Termini M, Vangeti S, Weir D, Zaslavsky E, Chikina M, Wu Y, van Bakel H, Letizia A, Sealfon S, Troyanskaya O. Pre-infection antiviral innate immunity contributes to sex differences in SARS-CoV-2 infection. Cell Syst. 2022;13(11):924–931.e4. PMCID: PMC9623453
    Reference Link
  • 1.
    French H, Pitre E, Oade M, Elshina E, Bisht K, King A, Bauer D, Velthuis A. Transient RNA structures cause aberrant influenza virus replication and innate immune activation. Sci Adv. 2022;8(36):eabp8655. PMCID: PMC9462681
    Reference Link
  • 1.
    Lim A, Menegatti S, Bustamante J, Le Bourhis L, Allez M, Rogge L, Casanova J-L, Yssel H, Di Santo J. IL-12 drives functional plasticity of human group 2 innate lymphoid cells. J Exp Med. 2016;213(4):569–83. PMCID: PMC4821648
    Reference Link
  • 1.
    Lim A, Verrier T, Vosshenrich C, Di Santo J. Developmental options and functional plasticity of innate lymphoid cells. Curr Opin Immunol. 2017;44:61–68. PMID: 28359987
    Reference Link
  • 1.
    Lim A, Li Y, Lopez-Lastra S, Stadhouders R, Paul F, Casrouge A, Serafini N, Puel A, Bustamante J, Surace L, Masse-Ranson G, David E, Strick-Marchand H, Le Bourhis L, Cocchi R, Topazio D, Graziano P, Muscarella L, Rogge L, Norel X, Sallenave J-M, Allez M, Graf T, Hendriks R, Casanova J-L, Amit I, Yssel H, Di Santo J. Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation. Cell. 2017;168(6):1086–1100.e10. PMID: 28283063
    Reference Link
  • 1.
    Justice J, Cristea I. Nuclear antiviral innate responses at the intersection of DNA sensing and DNA repair. Trends Microbiol. 2022;30(11):1056–1071. PMCID: PMC9560981
    Reference Link
  • 1.
    Kenney D, O’Connell A, Turcinovic J, Montanaro P, Hekman R, Tamura T, Berneshawi A, Cafiero T, Abdullatif S, Blum B, Goldstein S, Heller B, Gertje H, Bullitt E, Trachtenberg A, Chavez E, Nono E, Morrison C, Tseng A, Sheikh A, Kurnick S, Grosz K, Bosmann M, Ericsson M, Huber B, Saeed M, Balazs A, Francis K, Klose A, Paragas N, Campbell J, Connor J, Emili A, Crossland N, Ploss A, Douam F. Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection. Cell Rep. 2022;39(3):110714. PMCID: PMC8977517
    Reference Link
  • 1.
    Chitrakar A, Solorio-Kirpichyan K, Prangley E, Rath S, Du J, Korennykh A. Introns encode dsRNAs undetected by RIG-I/MDA5/interferons and sensed via RNase L. Proc Natl Acad Sci U S A. 2021;118(46). PMCID: PMC8609619
    Reference Link
  • 1.
    Elshina E, Velthuis A. The influenza virus RNA polymerase as an innate immune agonist and antagonist. Cell Mol Life Sci. 2021;78(23):7237–7256. PMCID: PMC8532088
    Reference Link
  • 1.
    Brooks J, Behrendt C, Ruhn K, Lee S, Raj P, Takahashi J, Hooper L. The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock. Cell. 2021;184(16):4154–4167.e12. PMCID: PMC8967342
    Reference Link
  • 1.
    Song B, Liu D, Greco T, Cristea I. Post-translational modification control of viral DNA sensors and innate immune signaling. Adv Virus Res. 2021;109:163–199. PMCID: PMC8489191
    Reference Link
  • 1.
    Lum K, Cristea I. Host Innate Immune Response and Viral Immune Evasion During Alphaherpesvirus Infection. Curr Issues Mol Biol. 2021;42:635–686. PMCID: PMC8301600
    Reference Link
  • 1.
    Ghergurovich J, García-Cañaveras J, Wang J, Schmidt E, Zhang Z, TeSlaa T, Patel H, Chen L, Britt E, Piqueras-Nebot M, Gomez-Cabrera M, Lahoz A, Fan J, Beier U, Kim H, Rabinowitz J. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol. 2020;16(7):731–739. PMCID: PMC7311271
    Reference Link
  • 1.
    Song B, Greco T, Lum K, Taber C, Cristea I. The DNA Sensor cGAS is Decorated by Acetylation and Phosphorylation Modifications in the Context of Immune Signaling. Mol Cell Proteomics. 2020;19(7):1193–1208. PMCID: PMC7338091
    Reference Link
  • 1.
    Lum K, Howard T, Pan C, Cristea I. Charge-Mediated Pyrin Oligomerization Nucleates Antiviral IFI16 Sensing of Herpesvirus DNA. mBio. 2019;10(4). PMCID: PMC6650555
    Reference Link
  • 1.
    Rath S, Prangley E, Donovan J, Demarest K, Wingreen N, Meir Y, Korennykh A. Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in the dsRNA Response. Mol Cell. 2019;75(6):1218–1228.e6. PMCID: PMC6754276
    Reference Link
  • 1.
    Liu Q, Johnson E, Lam R, Wang Q, Ye H, Wilson E, Minhas P, Liu L, Swarovski M, Tran S, Wang J, Mehta S, Yang X, Rabinowitz J, Yang S, Shamloo M, Mueller C, James M, Andreasson K. Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity. Nat Immunol. 2019;20(8):1023–1034. PMCID: PMC6778967
    Reference Link
  • 1.
    Winer B, Gaska J, Lipkowitz G, Bram Y, Parekh A, Parsons L, Leach R, Jindal R, Cho C, Shrirao A, Novik E, Schwartz R, Ploss A. Analysis of Host Responses to Hepatitis B and Delta Viral Infections in a Micro-scalable Hepatic Co-culture System. Hepatology. 2020;71(1):14–30. PMCID: PMC6917996
    Reference Link
  • 1.
    Minhas P, Liu L, Moon P, Joshi A, Dove C, Mhatre S, Contrepois K, Wang Q, Lee B, Coronado M, Bernstein D, Snyder M, Migaud M, Majeti R, Mochly-Rosen D, Rabinowitz J, Andreasson K. Macrophage de novo NAD synthesis specifies immune function in aging and inflammation. Nat Immunol. 2019;20(1):50–63. PMCID: PMC6768398
    Reference Link
  • 1.
    Mesev E, LeDesma R, Ploss A. Decoding type I and III interferon signalling during viral infection. Nat Microbiol. 2019;4(6):914–924. PMCID: PMC6554024
    Reference Link
  • 1.
    Ron-Harel N, Notarangelo G, Ghergurovich J, Paulo J, Sage P, Santos D, Satterstrom K, Gygi S, Rabinowitz J, Sharpe A, Haigis M. Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. Proc Natl Acad Sci U S A. 2018;115(52):13347–13352. PMCID: PMC6310842
    Reference Link
  • 1.
    Lum K, Song B, Federspiel J, Diner B, Howard T, Cristea I. Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS. Cell Syst. 2018;7(6):627–642.e6. PMCID: PMC6310102
    Reference Link
  • 1.
    Winer B, Shirvani-Dastgerdi E, Bram Y, Sellau J, Low B, Johnson H, Huang T, Hrebikova G, Heller B, Sharon Y, Giersch K, Gerges S, Seneca K, Pais M-A, Frankel A, Chiriboga L, Cullen J, Nahass R, Lutgehetmann M, Toettcher J, Wiles M, Schwartz R, Ploss A. Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Sci Transl Med. 2018;10(447). PMCID: PMC6337727
    Reference Link
  • 1.
    Ding Q, Gaska J, Douam F, Wei L, Kim D, Balev M, Heller B, Ploss A. Species-specific disruption of STING-dependent antiviral cellular defenses by the Zika virus NS2B3 protease. Proc Natl Acad Sci U S A. 2018;115(27):E6310-E6318. PMCID: PMC6142274
    Reference Link
  • 1.
    Douam F, Albrecht Y, Hrebikova G, Sadimin E, Davidson C, Kotenko S, Ploss A. Type III Interferon-Mediated Signaling Is Critical for Controlling Live Attenuated Yellow Fever Virus Infection . mBio. 2017;8(4). PMCID: PMC5559630
    Reference Link
  • 1.
    Enquist L, Leib D. Intrinsic and Innate Defenses of Neurons: Détente with the Herpesviruses. J Virol. 2017;91(1). PMCID: PMC5165195
    Reference Link
  • 1.
    Crow M, Lum K, Sheng X, Song B, Cristea I. Diverse mechanisms evolved by DNA viruses to inhibit early host defenses. Crit Rev Biochem Mol Biol. 2016;51(6):452–481. PMCID: PMC5285405
    Reference Link
  • 1.
    Han Y, Whitney G, Donovan J, Korennykh A. Innate immune messenger 2-5A tethers human RNase L into active high-order complexes. Cell Rep. 2012;2(4):902–13. PMID: 23084743
    Reference Link
  • 1.
    Donovan J, Whitney G, Rath S, Korennykh A. Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3. Proc Natl Acad Sci U S A. 2015;112(13):3949–54. PMCID: PMC4386348
    Reference Link
  • 1.
    Scull M, Shi C, de Jong Y, Gerold G, Ries M, von Schaewen M, Donovan B, Labitt R, Horwitz J, Gaska J, Hrebikova G, Xiao J, Flatley B, Fung C, Chiriboga L, Walker C, Evans D, Rice C, Ploss A. Hepatitis C virus infects rhesus macaque hepatocytes and simianized mice. Hepatology. 2015;62(1):57–67. PMCID: PMC4482775
    Reference Link
  • 1.
    Douam F, Gaska J, Winer B, Ding Q, von Schaewen M, Ploss A. Genetic Dissection of the Host Tropism of Human-Tropic Pathogens. Annu Rev Genet. 2015;49:21–45. PMCID: PMC5075990
    Reference Link

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