Department of Molecular Biology

Off screen link: Skip to content Off screen link: Skip to search
Princeton University
Home

Main Menu

  • Department
    Department
    • Chair’s Welcome
    • Administration & Staff
    • Associated Programs, Institutes & Departments
    • Grants Submission Policy & Funding Opportunities
    • Open Positions
    • MolBio Retreat 2024
      • MolBio Retreat 2024 Schedule
  • Faculty & Research
    Faculty & Research
    • Faculty
    • Research Areas
      • Biochemistry, Biophysics & Structural Biology
      • Cell Biology, Development & Cancer
      • Genetics & Genomics
      • Microbiology, Virology & Immunology
      • Quantitative & Computational Biology
  • Postdoc
    Postdoc
    • Overview
    • Prospective Postdoc
    • New Postdoc
    • Postdoc Community
    • Career Development
    • Lewis-Sigler Fellows
    • Contacts
  • Graduate
    Graduate
    • Overview
    • Admission & Financial Support
    • Requirements
    • Courses
    • MD/PhD Program
    • MolBio Scholars
    • Outreach Program
    • Faculty Graduate Committee
    • Department Life
      • Life in the Department
      • Graduate Student Committees
      • Career Resources
      • Student Life
      • Incoming Graduate Students
    • Molecular Biology Training Grants
  • Undergraduate
    Undergraduate
    • Overview
    • Teaching Mission
    • Major
      • Major Requirements
      • Departmentals
      • Declare a Major
      • Typical Paths
      • Courses
      • Minor & Certificate Programs
      • Study Abroad
      • Junior Independent Work
      • Senior Thesis
    • Research
      • Current Lab Assignments
      • Summer Research
      • Sophomore Research Course
      • Internship Milestone Credit
      • Undergraduate Publications
    • Career Resources
    • Community
      • Undergraduate Community
      • Important Dates and Deadlines
      • Class Day
    • Contacts
  • Core Facilities
    Core Facilities
    • Overview
    • Shared Imaging Facilities
      • Confocal Microscopy
        • Instruments
        • Fluorescent Dyes
        • ILab Calendar and Service Requests
        • User Training
        • Nikon Center of Excellence
        • Contact
      • Electron Microscopy
        • Equipment
        • Pricing
        • Contacts
      • Imaging & Analysis Center
      • Nikon Center of Excellence
    • Shared Research Facilities
      • Biophysics
      • Drosophila Media
      • Flow Cytometry
        • Facility Use
        • Instruments
        • ILab Calendar and Service Requests
        • Contact
      • Genome Editing Shared Resource (Rutgers-CINJ)
      • Histology
      • Lab Animal Resources
      • Macromolecular Crystallography
      • NMR Facility
      • Proteomics & Mass Spec
        • Proteomics & MS Services
        • Protocols & Guidelines
      • Research Computing
      • Sequencing & Microarray
      • Synseq
    • Other Facilities
      • IT Support
      • Facilities & Maintenance
      • Environmental Health & Safety (EHS)
  • Community
    Community
    • DEI Committee
    • Code of Conduct
  • Apply & Visit
  • Contact
  • People
  • Donors
  • News
  • Events
    • Events Archive

Search

Histones

  • 1.
    Lukasak B, Mitchener M, Kong L, Dul B, Lazarus C, Ramakrishnan A, Ni J, Shen L, Maze I, Muir T. TGM2-mediated histone transglutamination is dictated by steric accessibility. Proc Natl Acad Sci U S A. 2022;119(43):e2208672119. PMCID: PMC9618071
    Reference Link
  • 1.
    Mitchener M, Muir T. Oncohistones: Exposing the nuances and vulnerabilities of epigenetic regulation. Mol Cell. 2022;82(16):2925–2938. PMCID: PMC9482148
    Reference Link
  • 1.
    Dao H, Liu H, Mashtalir N, Kadoch C, Muir T. Synthesis of Oriented Hexasomes and Asymmetric Nucleosomes Using a Template Editing Process. J Am Chem Soc. 2022;144(5):2284–2291. PMCID: PMC8935522
    Reference Link
  • 1.
    Burton A, Hamza G, Zhang A, Muir T. Chemical biology approaches to study histone interactors. Biochem Soc Trans. 2021;49(5):2431–2441. PMCID: PMC9785950
    Reference Link
  • 1.
    Eeftens J, Kapoor M, Michieletto D, Brangwynne C. Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction. Nat Commun. 2021;12(1):5888. PMCID: PMC8497513
    Reference Link
  • 1.
    Mashtalir N, Dao H, Sankar A, Liu H, Corin A, Bagert J, Ge E, D’Avino A, Filipovski M, Michel B, Dann G, Muir T, Kadoch C. Chromatin landscape signals differentially dictate the activities of mSWI/SNF family complexes. Science. 2021;373(6552):306–315. PMCID: PMC8390793
    Reference Link
  • 1.
    Mitchener M, Muir T. Janus Bioparticles: Asymmetric Nucleosomes and Their Preparation Using Chemical Biology Approaches. Acc Chem Res. 2021;54(16):3215–3227. PMCID: PMC8411803
    Reference Link
  • 1.
    Hananya N, Daley S, Bagert J, Muir T. Synthesis of ADP-Ribosylated Histones Reveals Site-Specific Impacts on Chromatin Structure and Function. J Am Chem Soc. 2021;143(29):10847–10852. PMID: 34264659
    Reference Link
  • 1.
    Zhao S, Chuh K, Zhang B, Dul B, Thompson R, Farrelly L, Liu X, Xu N, Xue Y, Roeder R, Maze I, Muir T, Li H. Histone H3Q5 serotonylation stabilizes H3K4 methylation and potentiates its readout. Proc Natl Acad Sci U S A. 2021;118(6). PMCID: PMC8017887
    Reference Link
  • 1.
    Ing-Simmons E, Vaid R, Bing X, Levine M, Mannervik M, Vaquerizas J. Independence of chromatin conformation and gene regulation during Drosophila dorsoventral patterning. Nat Genet. 2021;53(4):487–499. PMCID: PMC8035076
    Reference Link
  • 1.
    Bagert J, Muir T. Molecular Epigenetics: Chemical Biology Tools Come of Age. Annu Rev Biochem. 2021;90:287–320. PMCID: PMC8284505
    Reference Link
  • 1.
    Wu A, Zhi J, Tian T, Cihan A, Cevher M, Liu Z, David Y, Muir T, Roeder R, Yu M. DOT1L complex regulates transcriptional initiation in human erythroleukemic cells. Proc Natl Acad Sci U S A. 2021;118(27). PMCID: PMC8271641
    Reference Link
  • 1.
    Bagert J, Mitchener M, Patriotis A, Dul B, Wojcik F, Nacev B, Feng L, Allis D, Muir T. Oncohistone mutations enhance chromatin remodeling and alter cell fates. Nat Chem Biol. 2021;17(4):403–411. PMCID: PMC8174649
    Reference Link
  • 1.
    Leicher R, Ge E, Lin X, Reynolds M, Xie W, Walz T, Zhang B, Muir T, Liu S. Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin. Proc Natl Acad Sci U S A. 2020;117(48):30465–30475. PMCID: PMC7720148
    Reference Link
  • 1.
    McBride M, Mashtalir N, Winter E, Dao H, Filipovski M, D’Avino A, Seo H-S, Umbreit N, St Pierre R, Valencia A, Qian K, Zullow H, Jaffe J, Dhe-Paganon S, Muir T, Kadoch C. The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma. Nat Struct Mol Biol. 2020;27(9):836–845. PMCID: PMC7714695
    Reference Link
  • 1.
    Anlas A, Nelson C. Living under Strain: How Epithelia Protect Their Genomes from Repeated Stretching. Biochemistry. 2020;59(30):2761–2763. PMID: 32702973
    Reference Link
  • 1.
    Xu Y, Zhang Y, García-Cañaveras J, Guo L, Kan M, Yu S, Blair I, Rabinowitz J, Yang X. Chaperone-mediated autophagy regulates the pluripotency of embryonic stem cells. Science. 2020;369(6502):397–403. PMCID: PMC7939502
    Reference Link
  • 1.
    Murawska M, Schauer T, Matsuda A, Wilson M, Pysik T, Wojcik F, Muir T, Hiraoka Y, Straub T, Ladurner A. The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions. Mol Cell. 2020;77(3):501–513.e7. PMCID: PMC7007867
    Reference Link
  • 1.
    Diehl K, Muir T. Chromatin as a key consumer in the metabolite economy. Nat Chem Biol. 2020;16(6):620–629. PMCID: PMC7258299
    Reference Link
  • 1.
    Burton A, Haugbro M, Gates L, Bagert J, Allis D, Muir T. In situ chromatin interactomics using a chemical bait and trap approach. Nat Chem. 2020;12(6):520–527. PMCID: PMC7331920
    Reference Link
  • 1.
    Dao H, Dul B, Dann G, Liszczak G, Muir T. A basic motif anchoring ISWI to nucleosome acidic patch regulates nucleosome spacing. Nat Chem Biol. 2020;16(2):134–142. PMCID: PMC6982587
    Reference Link
  • 1.
    Diehl K, Ge E, Weinberg D, Jani K, Allis D, Muir T. PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor. Proc Natl Acad Sci U S A. 2019;116(44):22152–22157. PMCID: PMC6825254
    Reference Link
  • 1.
    Albig C, Wang C, Dann G, Wojcik F, Schauer T, Krause S, Maenner S, Cai W, Li Y, Girton J, Muir T, Johansen J, Johansen K, Becker P, Regnard C. JASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila. Nat Commun. 2019;10(1):5343. PMCID: PMC6877644
    Reference Link
  • 1.
    Chen C-F, Pohl T, Chan A, Slocum J, Zakian V. Centromere RNA Is Negatively Regulated by Cbf1 and Its Unscheduled Synthesis Impacts CenH3 Binding. Genetics. 2019;213(2):465–479. PMCID: PMC6781895
    Reference Link
  • 1.
    Jain S, Do T, Lund P, Rashoff A, Diehl K, Cieslik M, Bajic A, Juretic N, Deshmukh S, Venneti S, Muir T, Garcia B, Jabado N, Lewis P. PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Nat Commun. 2019;10(1):2146. PMCID: PMC6513997
    Reference Link
  • 1.
    Farrelly L, Thompson R, Zhao S, Lepack A, Lyu Y, Bhanu N, Zhang B, Loh Y-H, Ramakrishnan A, Vadodaria K, Heard K, Erikson G, Nakadai T, Bastle R, Lukasak B, Zebroski H, Alenina N, Bader M, Berton O, Roeder R, Molina H, Gage F, Shen L, Garcia B, Li H, Muir T, Maze I. Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature. 2019;567(7749):535–539. PMCID: PMC6557285
    Reference Link
  • 1.
    Nacev B, Feng L, Bagert J, Lemiesz A, Gao J, Soshnev A, Kundra R, Schultz N, Muir T, Allis D. The expanding landscape of ’oncohistone’ mutations in human cancers. Nature. 2019;567(7749):473–478. PMCID: PMC6512987
    Reference Link
  • 1.
    Jani K, Jain S, Ge E, Diehl K, Lundgren S, Müller M, Lewis P, Muir T. Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase. Proc Natl Acad Sci U S A. 2019;116(17):8295–8300. PMCID: PMC6486736
    Reference Link
  • 1.
    Carabetta V, Greco T, Cristea I, Dubnau D. YfmK is an N-lysine acetyltransferase that directly acetylates the histone-like protein HBsu in . Proc Natl Acad Sci U S A. 2019;116(9):3752–3757. PMCID: PMC6397556
    Reference Link
  • 1.
    Tabuchi T, Rechtsteiner A, Jeffers T, Egelhofer T, Murphy C, Strome S. Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis. Nat Commun. 2018;9(1):4310. PMCID: PMC6193031
    Reference Link
  • 1.
    Jeon J, McGinty R, Muir T, Kim J-A, Kim J. Crosstalk among Set1 complex subunits involved in H2B ubiquitylation-dependent H3K4 methylation. Nucleic Acids Res. 2018;46(21):11129–11143. PMCID: PMC6265457
    Reference Link
  • 1.
    O’Connell B, Adamson B, Lydeard J, Sowa M, Ciccia A, Bredemeyer A, Schlabach M, Gygi S, Elledge S, Harper W. A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell. 2010;40(4):645–57. PMCID: PMC3006237
    Reference Link
  • 1.
    Liszczak G, Diehl K, Dann G, Muir T. Acetylation blocks DNA damage-induced chromatin ADP-ribosylation. Nat Chem Biol. 2018;14(9):837–840. PMCID: PMC6505472
    Reference Link
  • 1.
    Bos J, Muir T. A Chemical Probe for Protein Crotonylation. J Am Chem Soc. 2018;140(14):4757–4760. PMCID: PMC6505473
    Reference Link
  • 1.
    Wojcik F, Dann G, Beh L, Debelouchina G, Hofmann R, Muir T. Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants. Nat Commun. 2018;9(1):1394. PMCID: PMC5895630
    Reference Link
  • 1.
    Jenness C, Giunta S, Müller M, Kimura H, Muir T, Funabiki H. HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome. Proc Natl Acad Sci U S A. 2018;115(5):E876-E885. PMCID: PMC5798369
    Reference Link
  • 1.
    Wang X, Paucek R, Gooding A, Brown Z, Ge E, Muir T, Cech T. Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA. Nat Struct Mol Biol. 2017;24(12):1028–1038. PMCID: PMC5771497
    Reference Link
  • 1.
    Oberstein A, Shenk T. Cellular responses to human cytomegalovirus infection: Induction of a mesenchymal-to-epithelial transition (MET) phenotype. Proc Natl Acad Sci U S A. 2017;114(39):E8244-E8253. PMCID: PMC5625929
    Reference Link
  • 1.
    Dann G, Liszczak G, Bagert J, Müller M, Nguyen U, Wojcik F, Brown Z, Bos J, Panchenko T, Pihl R, Pollock S, Diehl K, Allis D, Muir T. ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference. Nature. 2017;548(7669):607–611. PMCID: PMC5777669
    Reference Link
  • 1.
    Santos J, Josling G, Ross P, Joshi P, Orchard L, Campbell T, Schieler A, Cristea I, Llinás M. Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor. Cell Host Microbe. 2017;21(6):731–741.e10. PMCID: PMC5855115
    Reference Link
  • 1.
    Holt M, David Y, Pollock S, Tang Z, Jeon J, Kim J, Roeder R, Muir T. Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin. Proc Natl Acad Sci U S A. 2015;112(33):10365–70. PMCID: PMC4547310
    Reference Link
  • 1.
    Lu C, Jain S, Hoelper D, Bechet D, Molden R, Ran L, Murphy D, Venneti S, Hameed M, Pawel B, Wunder J, Dickson B, Lundgren S, Jani K, De Jay N, Papillon-Cavanagh S, Andrulis I, Sawyer S, Grynspan D, Turcotte R, Nadaf J, Fahiminiyah S, Muir T, Majewski J, Thompson C, Chi P, Garcia B, Allis D, Jabado N, Lewis P. Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape. Science. 2016;352(6287):844–9. PMCID: PMC4928577
    Reference Link
  • 1.
    Su X, Wellen K, Rabinowitz J. Metabolic control of methylation and acetylation. Curr Opin Chem Biol. 2016;30:52–60. PMCID: PMC4731252
    Reference Link
  • 1.
    Müller M, Fierz B, Bittova L, Liszczak G, Muir T. A two-state activation mechanism controls the histone methyltransferase Suv39h1. Nat Chem Biol. 2016;12(3):188–93. PMCID: PMC4876634
    Reference Link
  • 1.
    Zhou L, Holt M, Ohashi N, Zhao A, Müller M, Wang B, Muir T. Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation. Nat Commun. 2016;7:10589. PMCID: PMC4740876
    Reference Link
  • 1.
    Arnaudo A, Link J, Garcia B. Bioorthogonal Chemistry for the Isolation and Study of Newly Synthesized Histones and Their Modifications. ACS Chem Biol. 2016;11(3):782–91. PMCID: PMC4844183
    Reference Link

Footer

Connect with Mol Bio

  • Facebook
  • Twitter

Department of Molecular Biology
119 Lewis Thomas Laboratory
Washington Road
Princeton, NJ 08544-1014
Need help? Contact us

Visitor Parking Information

Intranet Login

Privacy Notice

Explore

  • Graduate Program
  • Undergraduate Program
  • Summer Undergraduate Research Program (SURP)
  • Research Areas
  • Molecular Biology Faculty
  • Faculty Research Labs

Core Facilities & Instruments

  • Biophysics
  • Confocal Microscopy
  • Drosophila Media
  • Electron Microscopy
  • Flow Cytometry
  • Histology
  • Imaging Facility at LSI
  • Laboratory Animal Resources
  • Macromolecular Crystallography
  • Nikon Center of Excellence
  • Proteomics & Mass Spectrometry
  • Sequencing & Microarray
  • Synseq

Programs & Institutes

  • Graduate Program in Quantitative and Computational Biology
  • Glenn Laboratories For Aging Research
  • Lewis-Sigler Institute for Integrative Genomics
  • Princeton Neuroscience Institute
  • Diversity & Non-Discrimination
  • Accessibility Help

© 2025 The Trustees of Princeton University

Princeton University