Howard T, Lum K, Kennedy M, Cristea I. The Nuclear DNA Sensor IFI16 Indiscriminately Binds to and Diminishes Accessibility of the HSV-1 Genome to Suppress Infection. mSystems. 2022;7(3):e0019822. PMCID: PMC9239196

Kennedy M, Tyl M, Betsinger C, Federspiel J, Sheng X, Arbuckle J, Kristie T, Cristea I. A TRUSTED targeted mass spectrometry assay for pan-herpesvirus protein detection. Cell Rep. 2022;39(6):110810. PMCID: PMC9245836

Justice J, Kennedy M, Hutton J, Liu D, Song B, Phelan B, Cristea I. Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity. Sci Adv. 2021;7(25). PMCID: PMC8213230

Murray-Nerger L, Justice J, Rekapalli P, Hutton J, Cristea I. Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair. Nucleic Acids Res. 2021;49(4):2044–2064. PMCID: PMC7913768

Howard T, Cristea I. Interrogating Host Antiviral Environments Driven by Nuclear DNA Sensing: A Multiomic Perspective. Biomolecules. 2020;10(12). PMCID: PMC7761228

Scherer J, Hogue I, Yaffe Z, Tanneti N, Winer B, Vershinin M, Enquist L. A kinesin-3 recruitment complex facilitates axonal sorting of enveloped alpha herpesvirus capsids. PLoS Pathog. 2020;16(1):e1007985. PMCID: PMC7010296

Lum K, Howard T, Pan C, Cristea I. Charge-Mediated Pyrin Oligomerization Nucleates Antiviral IFI16 Sensing of Herpesvirus DNA. mBio. 2019;10(4). PMCID: PMC6650555

Durán A, Greco T, Vollmer B, Cristea I, Grünewald K, Topf M. Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships. PLoS Biol. 2019;17(6):e3000316. PMCID: PMC6594648

Lum K, Song B, Federspiel J, Diner B, Howard T, Cristea I. Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS. Cell Syst. 2018;7(6):627–642.e6. PMCID: PMC6310102

Beltran P, Cook K, Hashimoto Y, Galitzine C, Murray L, Vitek O, Cristea I. Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication. Cell Host Microbe. 2018;24(4):526–541.e7. PMCID: PMC6195127

Koyuncu O, MacGibeny M, Hogue I, Enquist L. Compartmented neuronal cultures reveal two distinct mechanisms for alpha herpesvirus escape from genome silencing. PLoS Pathog. 2017;13(10):e1006608. PMCID: PMC5658187

Crow M, Cristea I. Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation. Mol Cell Proteomics. 2017;16(4 suppl 1):S200-S214. PMCID: PMC5393386

Rowles D, Tsai Y-C, Greco T, Lin A, Li M, Yeh J, Cristea I. DNA methyltransferase DNMT3A associates with viral proteins and impacts HSV-1 infection. Proteomics. 2015;15(12):1968–82. PMCID: PMC4550099

Diner B, Lum K, Javitt A, Cristea I. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. Mol Cell Proteomics. 2015;14(9):2341–56. PMCID: PMC4563720

Ashford P, Hernandez A, Greco T, Buch A, Sodeik B, Cristea I, Grünewald K, Shepherd A, Topf M. HVint: A Strategy for Identifying Novel Protein-Protein Interactions in Herpes Simplex Virus Type 1. Mol Cell Proteomics. 2016;15(9):2939–53. PMCID: PMC5013309

Diner B, Lum K, Toettcher J, Cristea I. Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus Infection. mBio. 2016;7(6). PMCID: PMC5111403

Christensen M, Jensen S, Miettinen J, Luecke S, Prabakaran T, Reinert L, Mettenleiter T, Chen Z, Knipe D, Sandri-Goldin R, Enquist L, Hartmann R, Mogensen T, Rice S, Nyman T, Matikainen S, Paludan S. HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression. EMBO J. 2016;35(13):1385–99. PMCID: PMC4931188

Hogue I, Scherer J, Enquist L. Exocytosis of Alphaherpesvirus Virions, Light Particles, and Glycoproteins Uses Constitutive Secretory Mechanisms. mBio. 2016;7(3). PMCID: PMC4959669

Diner B, Li T, Greco T, Crow M, Fuesler J, Wang J, Cristea I. The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Mol Syst Biol. 2015;11(1):787. PMCID: PMC4358659

Hagen C, Dent K, Zeev-Ben-Mordehai T, Grange M, Bosse J, Whittle C, Klupp B, Siebert A, Vasishtan D, Bäuerlein F, Cheleski J, Werner S, Guttmann P, Rehbein S, Henzler K, Demmerle J, Adler B, Koszinowski U, Schermelleh L, Schneider G, Enquist L, Plitzko J, Mettenleiter T, Grünewald K. Structural Basis of Vesicle Formation at the Inner Nuclear Membrane. Cell. 2015;163(7):1692–701. PMCID: PMC4701712

Song R, Koyuncu O, Greco T, Diner B, Cristea I, Enquist L. Two Modes of the Axonal Interferon Response Limit Alphaherpesvirus Neuroinvasion. mBio. 2016;7(1):e02145–15. PMCID: PMC4742712