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Herpesvirus 1, Human

  • 1.
    Howard T, Lum K, Kennedy M, Cristea I. The Nuclear DNA Sensor IFI16 Indiscriminately Binds to and Diminishes Accessibility of the HSV-1 Genome to Suppress Infection. mSystems. 2022;7(3):e0019822. PMCID: PMC9239196
    Reference Link
  • 1.
    Kennedy M, Tyl M, Betsinger C, Federspiel J, Sheng X, Arbuckle J, Kristie T, Cristea I. A TRUSTED targeted mass spectrometry assay for pan-herpesvirus protein detection. Cell Rep. 2022;39(6):110810. PMCID: PMC9245836
    Reference Link
  • 1.
    Justice J, Kennedy M, Hutton J, Liu D, Song B, Phelan B, Cristea I. Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity. Sci Adv. 2021;7(25). PMCID: PMC8213230
    Reference Link
  • 1.
    Murray-Nerger L, Justice J, Rekapalli P, Hutton J, Cristea I. Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair. Nucleic Acids Res. 2021;49(4):2044–2064. PMCID: PMC7913768
    Reference Link
  • 1.
    Howard T, Cristea I. Interrogating Host Antiviral Environments Driven by Nuclear DNA Sensing: A Multiomic Perspective. Biomolecules. 2020;10(12). PMCID: PMC7761228
    Reference Link
  • 1.
    Scherer J, Hogue I, Yaffe Z, Tanneti N, Winer B, Vershinin M, Enquist L. A kinesin-3 recruitment complex facilitates axonal sorting of enveloped alpha herpesvirus capsids. PLoS Pathog. 2020;16(1):e1007985. PMCID: PMC7010296
    Reference Link
  • 1.
    Lum K, Howard T, Pan C, Cristea I. Charge-Mediated Pyrin Oligomerization Nucleates Antiviral IFI16 Sensing of Herpesvirus DNA. mBio. 2019;10(4). PMCID: PMC6650555
    Reference Link
  • 1.
    Durán A, Greco T, Vollmer B, Cristea I, Grünewald K, Topf M. Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships. PLoS Biol. 2019;17(6):e3000316. PMCID: PMC6594648
    Reference Link
  • 1.
    Lum K, Song B, Federspiel J, Diner B, Howard T, Cristea I. Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS. Cell Syst. 2018;7(6):627–642.e6. PMCID: PMC6310102
    Reference Link
  • 1.
    Beltran P, Cook K, Hashimoto Y, Galitzine C, Murray L, Vitek O, Cristea I. Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication. Cell Host Microbe. 2018;24(4):526–541.e7. PMCID: PMC6195127
    Reference Link
  • 1.
    Koyuncu O, MacGibeny M, Hogue I, Enquist L. Compartmented neuronal cultures reveal two distinct mechanisms for alpha herpesvirus escape from genome silencing. PLoS Pathog. 2017;13(10):e1006608. PMCID: PMC5658187
    Reference Link
  • 1.
    Crow M, Cristea I. Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation. Mol Cell Proteomics. 2017;16(4 suppl 1):S200-S214. PMCID: PMC5393386
    Reference Link
  • 1.
    Rowles D, Tsai Y-C, Greco T, Lin A, Li M, Yeh J, Cristea I. DNA methyltransferase DNMT3A associates with viral proteins and impacts HSV-1 infection. Proteomics. 2015;15(12):1968–82. PMCID: PMC4550099
    Reference Link
  • 1.
    Diner B, Lum K, Javitt A, Cristea I. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. Mol Cell Proteomics. 2015;14(9):2341–56. PMCID: PMC4563720
    Reference Link
  • 1.
    Ashford P, Hernandez A, Greco T, Buch A, Sodeik B, Cristea I, Grünewald K, Shepherd A, Topf M. HVint: A Strategy for Identifying Novel Protein-Protein Interactions in Herpes Simplex Virus Type 1. Mol Cell Proteomics. 2016;15(9):2939–53. PMCID: PMC5013309
    Reference Link
  • 1.
    Diner B, Lum K, Toettcher J, Cristea I. Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus Infection. mBio. 2016;7(6). PMCID: PMC5111403
    Reference Link
  • 1.
    Christensen M, Jensen S, Miettinen J, Luecke S, Prabakaran T, Reinert L, Mettenleiter T, Chen Z, Knipe D, Sandri-Goldin R, Enquist L, Hartmann R, Mogensen T, Rice S, Nyman T, Matikainen S, Paludan S. HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression. EMBO J. 2016;35(13):1385–99. PMCID: PMC4931188
    Reference Link
  • 1.
    Hogue I, Scherer J, Enquist L. Exocytosis of Alphaherpesvirus Virions, Light Particles, and Glycoproteins Uses Constitutive Secretory Mechanisms. mBio. 2016;7(3). PMCID: PMC4959669
    Reference Link
  • 1.
    Diner B, Li T, Greco T, Crow M, Fuesler J, Wang J, Cristea I. The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Mol Syst Biol. 2015;11(1):787. PMCID: PMC4358659
    Reference Link
  • 1.
    Hagen C, Dent K, Zeev-Ben-Mordehai T, Grange M, Bosse J, Whittle C, Klupp B, Siebert A, Vasishtan D, Bäuerlein F, Cheleski J, Werner S, Guttmann P, Rehbein S, Henzler K, Demmerle J, Adler B, Koszinowski U, Schermelleh L, Schneider G, Enquist L, Plitzko J, Mettenleiter T, Grünewald K. Structural Basis of Vesicle Formation at the Inner Nuclear Membrane. Cell. 2015;163(7):1692–701. PMCID: PMC4701712
    Reference Link
  • 1.
    Song R, Koyuncu O, Greco T, Diner B, Cristea I, Enquist L. Two Modes of the Axonal Interferon Response Limit Alphaherpesvirus Neuroinvasion. mBio. 2016;7(1):e02145–15. PMCID: PMC4742712
    Reference Link

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