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Hepatocytes

  • 1.
    Zhang Z, TeSlaa T, Xu X, Zeng X, Yang L, Xing G, Tesz G, Clasquin M, Rabinowitz J. Serine catabolism generates liver NADPH and supports hepatic lipogenesis. Nat Metab. 2021;3(12):1608–1620. PMCID: PMC8721747
    Reference Link
  • 1.
    Guan D, Xiong Y, Trinh T, Xiao Y, Hu W, Jiang C, Dierickx P, Jang C, Rabinowitz J, Lazar M. The hepatocyte clock and feeding control chronophysiology of multiple liver cell types. Science. 2020;369(6509):1388–1394. PMCID: PMC7849028
    Reference Link
  • 1.
    Zhao S, Jang C, Liu J, Uehara K, Gilbert M, Izzo L, Zeng X, Trefely S, Fernandez S, Carrer A, Miller K, Schug Z, Snyder N, Gade T, Titchenell P, Rabinowitz J, Wellen K. Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate. Nature. 2020;579(7800):586–591. PMCID: PMC7416516
    Reference Link
  • 1.
    Wei L, Ploss A. Core components of DNA lagging strand synthesis machinery are essential for hepatitis B virus cccDNA formation. Nat Microbiol. 2020;5(5):715–726. PMCID: PMC7190442
    Reference Link
  • 1.
    Winer B, Edgel K, Zou X, Sellau J, Hadiwidjojo S, Garver L, McDonough C, Kelleher N, Thomas P, Villasante E, Ploss A, Gerbasi V. Identification of Plasmodium falciparum proteoforms from liver stage models. Malar J. 2020;19(1):10. PMCID: PMC6947969
    Reference Link
  • 1.
    Winer B, Gaska J, Lipkowitz G, Bram Y, Parekh A, Parsons L, Leach R, Jindal R, Cho C, Shrirao A, Novik E, Schwartz R, Ploss A. Analysis of Host Responses to Hepatitis B and Delta Viral Infections in a Micro-scalable Hepatic Co-culture System. Hepatology. 2020;71(1):14–30. PMCID: PMC6917996
    Reference Link
  • 1.
    Poillet-Perez L, Xie X, Zhan L, Yang Y, Sharp D, Hu Z, Su X, Maganti A, Jiang C, Lu W, Zheng H, Bosenberg M, Mehnert J, Guo J, Lattime E, Rabinowitz J, White E. Autophagy maintains tumour growth through circulating arginine. Nature. 2018;563(7732):569–573. PMCID: PMC6287937
    Reference Link
  • 1.
    Winer B, Shirvani-Dastgerdi E, Bram Y, Sellau J, Low B, Johnson H, Huang T, Hrebikova G, Heller B, Sharon Y, Giersch K, Gerges S, Seneca K, Pais M-A, Frankel A, Chiriboga L, Cullen J, Nahass R, Lutgehetmann M, Toettcher J, Wiles M, Schwartz R, Ploss A. Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Sci Transl Med. 2018;10(447). PMCID: PMC6337727
    Reference Link
  • 1.
    Miller R, Shi Y, Lu W, Pirman D, Jatkar A, Blatnik M, Wu H, Cárdenas C, Wan M, Foskett K, Park J, Zhang Y, Holland W, Rabinowitz J, Birnbaum M. Targeting hepatic glutaminase activity to ameliorate hyperglycemia. Nat Med. 2018;24(4):518–524. PMCID: PMC6089616
    Reference Link
  • 1.
    Nimgaonkar I, Ding Q, Schwartz R, Ploss A. Hepatitis E virus: advances and challenges. Nat Rev Gastroenterol Hepatol. 2018;15(2):96–110. PMID: 29162935
    Reference Link
  • 1.
    Winer B, Huang T, Pludwinski E, Heller B, Wojcik F, Lipkowitz G, Parekh A, Cho C, Shrirao A, Muir T, Novik E, Ploss A. Long-term hepatitis B infection in a scalable hepatic co-culture system. Nat Commun. 2017;8(1):125. PMCID: PMC5527081
    Reference Link
  • 1.
    Titchenell P, Quinn W, Lu M, Chu Q, Lu W, Li C, Chen H, Monks B, Chen J, Rabinowitz J, Birnbaum M. Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production. Cell Metab. 2016;23(6):1154–1166. PMCID: PMC4909537
    Reference Link
  • 1.
    von Schaewen M, Dorner M, Hueging K, Foquet L, Gerges S, Hrebikova G, Heller B, Bitzegeio J, Doerrbecker J, Horwitz J, Gerold G, Suerbaum S, Rice C, Meuleman P, Pietschmann T, Ploss A. Expanding the Host Range of Hepatitis C Virus through Viral Adaptation. mBio. 2016;7(6). PMCID: PMC5101358
    Reference Link
  • 1.
    Winer B, Huang T, Low B, Avery C, Pais M-A, Hrebikova G, Siu E, Chiriboga L, Wiles M, Ploss A. Recapitulation of treatment response patterns in a novel humanized mouse model for chronic hepatitis B virus infection. Virology. 2017;502:63–72. PMCID: PMC5414730
    Reference Link
  • 1.
    von Schaewen M, Hrebikova G, Ploss A. Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens. Methods Mol Biol. 2016;1438:79–101. PMID: 27150085
    Reference Link
  • 1.
    Scull M, Shi C, de Jong Y, Gerold G, Ries M, von Schaewen M, Donovan B, Labitt R, Horwitz J, Gaska J, Hrebikova G, Xiao J, Flatley B, Fung C, Chiriboga L, Walker C, Evans D, Rice C, Ploss A. Hepatitis C virus infects rhesus macaque hepatocytes and simianized mice. Hepatology. 2015;62(1):57–67. PMCID: PMC4482775
    Reference Link

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