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Glutamine

  • 1.
    Lukasak B, Mitchener M, Kong L, Dul B, Lazarus C, Ramakrishnan A, Ni J, Shen L, Maze I, Muir T. TGM2-mediated histone transglutamination is dictated by steric accessibility. Proc Natl Acad Sci U S A. 2022;119(43):e2208672119. PMCID: PMC9618071
    Reference Link
  • 1.
    Zhang Z, TeSlaa T, Xu X, Zeng X, Yang L, Xing G, Tesz G, Clasquin M, Rabinowitz J. Serine catabolism generates liver NADPH and supports hepatic lipogenesis. Nat Metab. 2021;3(12):1608–1620. PMCID: PMC8721747
    Reference Link
  • 1.
    Zhao S, Chuh K, Zhang B, Dul B, Thompson R, Farrelly L, Liu X, Xu N, Xue Y, Roeder R, Maze I, Muir T, Li H. Histone H3Q5 serotonylation stabilizes H3K4 methylation and potentiates its readout. Proc Natl Acad Sci U S A. 2021;118(6). PMCID: PMC8017887
    Reference Link
  • 1.
    Murashige D, Jang C, Neinast M, Edwards J, Cowan A, Hyman M, Rabinowitz J, Frankel D, Arany Z. Comprehensive quantification of fuel use by the failing and nonfailing human heart. Science. 2020;370(6514):364–368. PMCID: PMC7871704
    Reference Link
  • 1.
    Farrelly L, Thompson R, Zhao S, Lepack A, Lyu Y, Bhanu N, Zhang B, Loh Y-H, Ramakrishnan A, Vadodaria K, Heard K, Erikson G, Nakadai T, Bastle R, Lukasak B, Zebroski H, Alenina N, Bader M, Berton O, Roeder R, Molina H, Gage F, Shen L, Garcia B, Li H, Muir T, Maze I. Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature. 2019;567(7749):535–539. PMCID: PMC6557285
    Reference Link
  • 1.
    Miller R, Shi Y, Lu W, Pirman D, Jatkar A, Blatnik M, Wu H, Cárdenas C, Wan M, Foskett K, Park J, Zhang Y, Holland W, Rabinowitz J, Birnbaum M. Targeting hepatic glutaminase activity to ameliorate hyperglycemia. Nat Med. 2018;24(4):518–524. PMCID: PMC6089616
    Reference Link
  • 1.
    Pavlova N, Hui S, Ghergurovich J, Fan J, Intlekofer A, White R, Rabinowitz J, Thompson C, Zhang J. As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid. Cell Metab. 2018;27(2):428–438.e5. PMCID: PMC5803449
    Reference Link
  • 1.
    Hui S, Ghergurovich J, Morscher R, Jang C, Teng X, Lu W, Esparza L, Reya T, Guo J, White E, Rabinowitz J. Glucose feeds the TCA cycle via circulating lactate. Nature. 2017;551(7678):115–118. PMCID: PMC5898814
    Reference Link
  • 1.
    Rajeshkumar N, Yabuuchi S, Pai S, De Oliveira E, Kamphorst J, Rabinowitz J, Tejero H, Al-Shahrour F, Hidalgo M, Maitra A, Dang C. Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin. Clin Cancer Res. 2017;23(18):5639–5647. PMCID: PMC6540110
    Reference Link
  • 1.
    Guo J, Teng X, Laddha S, Ma S, Van Nostrand S, Yang Y, Khor S, Chan C, Rabinowitz J, White E. Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes Dev. 2016;30(15):1704–17. PMCID: PMC5002976
    Reference Link
  • 1.
    Moloughney J, Kim P, Vega-Cotto N, Wu C-C, Zhang S, Adlam M, Lynch T, Chou P-C, Rabinowitz J, Werlen G, Jacinto E. mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1. Mol Cell. 2016;63(5):811–26. PMCID: PMC5006067
    Reference Link

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