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Glucose

  • 1.
    Jiang X, Yan N, Deng D, Yan C. Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect. IUBMB Life. 2022;74(12):1180–1199. PMID: 36082803
    Reference Link
  • 1.
    Xiao T, Khan A, Shen Y, Chen L, Rabinowitz J. Glucose feeds the tricarboxylic acid cycle via excreted ethanol in fermenting yeast. Nat Chem Biol. 2022;18(12):1380–1387. PMCID: 1082793
    Reference Link
  • 1.
    Wang N, Zhang S, Yuan Y, Xu H, Defossa E, Matter H, Besenius M, Derdau V, Dreyer M, Halland N, He K, Petry S, Podeschwa M, Tennagels N, Jiang X, Yan N. Molecular basis for inhibiting human glucose transporters by exofacial inhibitors. Nat Commun. 2022;13(1):2632. PMCID: PMC9098912
    Reference Link
  • 1.
    Yuan Y, Kong F, Xu H, Zhu A, Yan N, Yan C. Cryo-EM structure of human glucose transporter GLUT4. Nat Commun. 2022;13(1):2671. PMCID: PMC9106701
    Reference Link
  • 1.
    Resnikoff H, Miller C, Schwarzbauer J. Implications of fibrotic extracellular matrix in diabetic retinopathy. Exp Biol Med (Maywood). 2022;247(13):1093–1102. PMCID: PMC9335512
    Reference Link
  • 1.
    Li X, Hui S, Mirek E, Jonsson W, Anthony T, Lee W, Zeng X, Jang C, Rabinowitz J. Circulating metabolite homeostasis achieved through mass action. Nat Metab. 2022;4(1):141–152. PMCID: PMC9244777
    Reference Link
  • 1.
    Olszewski K, Barsotti A, Feng X-J, Momcilovic M, Liu K, Kim J-I, Morris K, Lamarque C, Gaffney J, Yu X, Patel J, Rabinowitz J, Shackelford D, Poyurovsky M. Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors. Cell Chem Biol. 2022;29(3):423–435.e10. PMID: 34715056
    Reference Link
  • 1.
    Ghergurovich J, Lang J, Levin M, Briones N, Facista S, Mueller C, Cowan A, McBride M, Rodriguez E, Killian A, Dao T, Lamont J, Barron A, Su X, Hendricks W, Espina V, Von Hoff D, O’Shaughnessy J, Rabinowitz J. Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer. Med. 2021;2(6):736–754. PMCID: PMC8248508
    Reference Link
  • 1.
    Huang J, Yuan Y, Zhao N, Pu D, Tang Q, Zhang S, Luo S, Yang X, Wang N, Xiao Y, Zhang T, Liu Z, Sakata-Kato T, Jiang X, Kato N, Yan N, Yin H. Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents. Proc Natl Acad Sci U S A. 2021;118(3). PMCID: PMC7826358
    Reference Link
  • 1.
    Minhas P, Latif-Hernandez A, McReynolds M, Durairaj A, Wang Q, Rubin A, Joshi A, He J, Gauba E, Liu L, Wang C, Linde M, Sugiura Y, Moon P, Majeti R, Suematsu M, Mochly-Rosen D, Weissman I, Longo F, Rabinowitz J, Andreasson K. Restoring metabolism of myeloid cells reverses cognitive decline in ageing. Nature. 2021;590(7844):122–128. PMCID: PMC8274816
    Reference Link
  • 1.
    Green R, Wang L, Hart S, Lu W, Skelding D, Burton J, Mi H, Capel A, Chen H, Lin A, Subramaniam A, Rabinowitz J, Shou W. Metabolic excretion associated with nutrient-growth dysregulation promotes the rapid evolution of an overt metabolic defect. PLoS Biol. 2020;18(8):e3000757. PMCID: PMC7470746
    Reference Link
  • 1.
    Jiang X, Yuan Y, Huang J, Zhang S, Luo S, Wang N, Pu D, Zhao N, Tang Q, Hirata K, Yang X, Jiao Y, Sakata-Kato T, Wu J-W, Yan C, Kato N, Yin H, Yan N. Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum. Cell. 2020;183(1):258–268.e12. PMID: 32860739
    Reference Link
  • 1.
    Hui S, Cowan A, Zeng X, Yang L, TeSlaa T, Li X, Bartman C, Zhang Z, Jang C, Wang L, Lu W, Rojas J, Baur J, Rabinowitz J. Quantitative Fluxomics of Circulating Metabolites. Cell Metab. 2020;32(4):676–688.e4. PMCID: PMC7544659
    Reference Link
  • 1.
    Rabinowitz J, Enerbäck S. Lactate: the ugly duckling of energy metabolism. Nat Metab. 2020;2(7):566–571. PMCID: PMC7983055
    Reference Link
  • 1.
    Gibney P, Chen A, Schieler A, Chen J, Xu Y, Hendrickson D, McIsaac S, Rabinowitz J, Botstein D. A tps1Δ persister-like state in Saccharomyces cerevisiae is regulated by MKT1. PLoS One. 2020;15(5):e0233779. PMCID: PMC7259636
    Reference Link
  • 1.
    Ghergurovich J, García-Cañaveras J, Wang J, Schmidt E, Zhang Z, TeSlaa T, Patel H, Chen L, Britt E, Piqueras-Nebot M, Gomez-Cabrera M, Lahoz A, Fan J, Beier U, Kim H, Rabinowitz J. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol. 2020;16(7):731–739. PMCID: PMC7311271
    Reference Link
  • 1.
    Lane S, Zhang Y, Yun E, Ziolkowski L, Zhang G, Jin Y-S, Avalos J. Xylose assimilation enhances the production of isobutanol in engineered Saccharomyces cerevisiae. Biotechnol Bioeng. 2020;117(2):372–381. PMID: 31631318
    Reference Link
  • 1.
    Park J, Tanner L, Wei M, Khana D, Jacobson T, Zhang Z, Rubin S, Li S, Higgins M, Stevenson D, Amador-Noguez D, Rabinowitz J. Near-equilibrium glycolysis supports metabolic homeostasis and energy yield. Nat Chem Biol. 2019;15(10):1001–1008. PMID: 31548693
    Reference Link
  • 1.
    García-Cañaveras J, Chen L, Rabinowitz J. The Tumor Metabolic Microenvironment: Lessons from Lactate. Cancer Res. 2019;79(13):3155–3162. PMCID: PMC6606343
    Reference Link
  • 1.
    Tanner L, Goglia A, Wei M, Sehgal T, Parsons L, Park J, White E, Toettcher J, Rabinowitz J. Four Key Steps Control Glycolytic Flux in Mammalian Cells. Cell Syst. 2018;7(1):49–62.e8. PMCID: PMC6062487
    Reference Link
  • 1.
    Jang C, Hui S, Lu W, Cowan A, Morscher R, Lee G, Liu W, Tesz G, Birnbaum M, Rabinowitz J. The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. Cell Metab. 2018;27(2):351–361.e3. PMCID: PMC6032988
    Reference Link
  • 1.
    Liu L, Rowe G, Yang S, Li J, Damilano F, Chan M, Lu W, Jang C, Wada S, Morley M, Hesse M, Fleischmann B, Rabinowitz J, Das S, Rosenzweig A, Arany Z. PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy. Circ Res. 2017;121(12):1370–1378. PMCID: PMC5722682
    Reference Link
  • 1.
    Yan N. A Glimpse of Membrane Transport through Structures-Advances in the Structural Biology of the GLUT Glucose Transporters. J Mol Biol. 2017;429(17):2710–2725. PMID: 28756087
    Reference Link
  • 1.
    Sun L, Zeng X, Yan C, Sun X, Gong X, Rao Y, Yan N. Crystal structure of a bacterial homologue of glucose transporters GLUT1-4. Nature. 2012;490(7420):361–6. PMID: 23075985
    Reference Link
  • 1.
    Deng D, Yan N. GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters. Protein Sci. 2016;25(3):546–58. PMCID: PMC4815417
    Reference Link
  • 1.
    Deng D, Sun P, Yan C, Ke M, Jiang X, Xiong L, Ren W, Hirata K, Yamamoto M, Fan S, Yan N. Molecular basis of ligand recognition and transport by glucose transporters. Nature. 2015;526(7573):391–6. PMID: 26176916
    Reference Link
  • 1.
    Hui S, Ghergurovich J, Morscher R, Jang C, Teng X, Lu W, Esparza L, Reya T, Guo J, White E, Rabinowitz J. Glucose feeds the TCA cycle via circulating lactate. Nature. 2017;551(7678):115–118. PMCID: PMC5898814
    Reference Link
  • 1.
    Zhang Y, Kurupati R, Liu L, Zhou X, Zhang G, Hudaihed A, Filisio F, Giles-Davis W, Xu X, Karakousis G, Schuchter L, Xu W, Amaravadi R, Xiao M, Sadek N, Krepler C, Herlyn M, Freeman G, Rabinowitz J, Ertl H. Enhancing CD8 T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy. Cancer Cell. 2017;32(3):377–391.e9. PMCID: PMC5751418
    Reference Link
  • 1.
    Bren A, Park J, Towbin B, Dekel E, Rabinowitz J, Alon U. Glucose becomes one of the worst carbon sources for E.coli on poor nitrogen sources due to suboptimal levels of cAMP. Sci Rep. 2016;6:24834. PMCID: PMC4843011
    Reference Link
  • 1.
    Titchenell P, Quinn W, Lu M, Chu Q, Lu W, Li C, Chen H, Monks B, Chen J, Rabinowitz J, Birnbaum M. Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production. Cell Metab. 2016;23(6):1154–1166. PMCID: PMC4909537
    Reference Link
  • 1.
    Frederick D, Loro E, Liu L, Davila A, Chellappa K, Silverman I, Quinn W, Gosai S, Tichy E, Davis J, Mourkioti F, Gregory B, Dellinger R, Redpath P, Migaud M, Nakamaru-Ogiso E, Rabinowitz J, Khurana T, Baur J. Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle. Cell Metab. 2016;24(2):269–82. PMCID: PMC4985182
    Reference Link
  • 1.
    Moloughney J, Kim P, Vega-Cotto N, Wu C-C, Zhang S, Adlam M, Lynch T, Chou P-C, Rabinowitz J, Werlen G, Jacinto E. mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1. Mol Cell. 2016;63(5):811–26. PMCID: PMC5006067
    Reference Link
  • 1.
    Papazyan R, Sun Z, Kim Y, Titchenell P, Hill D, Lu W, Damle M, Wan M, Zhang Y, Briggs E, Rabinowitz J, Lazar M. Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. Cell Metab. 2016;24(6):863–874. PMCID: PMC5159233
    Reference Link
  • 1.
    Rosario W, Singh I, Wautlet A, Patterson C, Flak J, Becker T, Ali A, Tamarina N, Philipson L, Enquist L, Myers M, Rhodes C. The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions. Diabetes. 2016;65(9):2711–23. PMCID: PMC5001176
    Reference Link
  • 1.
    Mok W, Park J, Rabinowitz J, Brynildsen M. RNA Futile Cycling in Model Persisters Derived from MazF Accumulation. mBio. 2015;6(6):e01588–15. PMCID: PMC4659464
    Reference Link
  • 1.
    Miller C, Pozzi A, Zent R, Schwarzbauer J. Effects of high glucose on integrin activity and fibronectin matrix assembly by mesangial cells. Mol Biol Cell. 2014;25(16):2342–50. PMCID: PMC4142608
    Reference Link
  • 1.
    Surette M, Bassler B. Regulation of autoinducer production in Salmonella typhimurium. Mol Microbiol. 1999;31(2):585–95. PMID: 10027975
    Reference Link

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