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Enzyme Inhibitors

  • 1.
    Ghergurovich J, García-Cañaveras J, Wang J, Schmidt E, Zhang Z, TeSlaa T, Patel H, Chen L, Britt E, Piqueras-Nebot M, Gomez-Cabrera M, Lahoz A, Fan J, Beier U, Kim H, Rabinowitz J. A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat Chem Biol. 2020;16(7):731–739. PMCID: PMC7311271
    Reference Link
  • 1.
    Hermans D, Gautam S, García-Cañaveras J, Gromer D, Mitra S, Spolski R, Li P, Christensen S, Nguyen R, Lin J-X, Oh J, Du N, Veenbergen S, Fioravanti J, Ebina-Shibuya R, Bleck C, Neckers L, Rabinowitz J, Gattinoni L, Leonard W. Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8 T cell stemness and antitumor immunity. Proc Natl Acad Sci U S A. 2020;117(11):6047–6055. PMCID: PMC7084161
    Reference Link
  • 1.
    Valastyan J, Tota M, Taylor I, Stergioula V, Hone G, Smith C, Henke B, Carson K, Bassler B. Discovery of PqsE Thioesterase Inhibitors for Using DNA-Encoded Small Molecule Library Screening. ACS Chem Biol. 2020;15(2):446–456. PMCID: PMC7036018
    Reference Link
  • 1.
    Brown A, Chua N, Yan N. The shape of human squalene epoxidase expands the arsenal against cancer. Nat Commun. 2019;10(1):888. PMCID: PMC6384927
    Reference Link
  • 1.
    He W, Brumos J, Li H, Ji Y, Ke M, Gong X, Zeng Q, Li W, Zhang X, An F, Wen X, Li P, Chu J, Sun X, Yan C, Yan N, Xie D-Y, Raikhel N, Yang Z, Stepanova A, Alonso J, Guo H. A small-molecule screen identifies L-kynurenine as a competitive inhibitor of TAA1/TAR activity in ethylene-directed auxin biosynthesis and root growth in Arabidopsis. Plant Cell. 2011;23(11):3944–60. PMCID: PMC3246337
    Reference Link
  • 1.
    Ducker G, Ghergurovich J, Mainolfi N, Suri V, Jeong S, Li S, Friedman A, Manfredi M, Gitai Z, Kim H, Rabinowitz J. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017;114(43):11404–11409. PMCID: PMC5664509
    Reference Link

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