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Drug Discovery

  • 1.
    Wilke A, Doebele C, Zindel A, Lee K, Rieke S, Ceribelli M, Comoglio F, Phelan J, Wang J, Pikman Y, Jahn D, Häupl B, Schneider C, Scheich S, Tosto F, Bohnenberger H, Stauder P, Schnütgen F, Slabicki M, Coulibaly Z, Wolf S, Bojarczuk K, Chapuy B, Brandts C, Stroebel P, Lewis C, Engelke M, Xu X, Kim H, Dang T, Schmitz R, Hodson D, Stegmaier K, Urlaub H, Serve H, Schmitt C, Kreuz F, Knittel G, Rabinowitz J, Reinhardt H, Heiden M, Thomas C, Staudt L, Zenz T, Oellerich T. SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. Blood. 2022;139(4):538–553. PMCID: PMC8938936
    Reference Link
  • 1.
    Nimgaonkar I, Archer N, Becher I, Shahrad M, LeDesma R, Mateus A, Caballero-Gómez J, Berneshawi A, Ding Q, Douam F, Gaska J, Savitski M, Kim H, Ploss A. Isocotoin suppresses hepatitis E virus replication through inhibition of heat shock protein 90. Antiviral Res. 2021;185:104997. PMCID: PMC8649941
    Reference Link
  • 1.
    Cheung-Lee W, Parry M, Zong C, Cartagena A, Darst S, Connell N, Russo R, Link J. Discovery of Ubonodin, an Antimicrobial Lasso Peptide Active against Members of the Burkholderia cepacia Complex. Chembiochem. 2020;21(9):1335–1340. PMCID: PMC7205569
    Reference Link
  • 1.
    Liu M, El-Hossary E, Oelschlaeger T, Donia M, Quinn R, Abdelmohsen U. Potential of marine natural products against drug-resistant bacterial infections. Lancet Infect Dis. 2019;19(7):e237-e245. PMID: 31031171
    Reference Link
  • 1.
    Seyedsayamdost M. Toward a global picture of bacterial secondary metabolism. J Ind Microbiol Biotechnol. 2019;46(3-4):301–311. PMCID: PMC6779422
    Reference Link
  • 1.
    Tuttle R, Demko A, Patin N, Kapono C, Donia M, Dorrestein P, Jensen P. Detection of Natural Products and Their Producers in Ocean Sediments. Appl Environ Microbiol. 2019;85(8). PMCID: PMC6450032
    Reference Link
  • 1.
    Moon K, Xu F, Zhang C, Seyedsayamdost M. Bioactivity-HiTES Unveils Cryptic Antibiotics Encoded in Actinomycete Bacteria. ACS Chem Biol. 2019;14(4):767–774. PMCID: PMC6813803
    Reference Link
  • 1.
    Cheung-Lee W, Parry M, Cartagena A, Darst S, Link J. Discovery and structure of the antimicrobial lasso peptide citrocin. J Biol Chem. 2019;294(17):6822–6830. PMCID: PMC6497930
    Reference Link
  • 1.
    Pan X, Li Z, Zhou Q, Shen H, Wu K, Huang X, Chen J, Zhang J, Zhu X, Lei J, Xiong W, Gong H, Xiao B, Yan N. Structure of the human voltage-gated sodium channel Na1.4 in complex with β1. Science. 2018;362(6412). PMID: 30190309
    Reference Link
  • 1.
    Xu F, Nazari B, Moon K, Bushin L, Seyedsayamdost M. Discovery of a Cryptic Antifungal Compound from Streptomyces albus J1074 Using High-Throughput Elicitor Screens. J Am Chem Soc. 2017;139(27):9203–9212. PMCID: PMC5617735
    Reference Link
  • 1.
    Seyedsayamdost M. High-throughput platform for the discovery of elicitors of silent bacterial gene clusters. Proc Natl Acad Sci U S A. 2014;111(20):7266–71. PMCID: PMC4034229
    Reference Link
  • 1.
    Webb C, Zakian V. Telomerase RNA is more than a DNA template. RNA Biol. 2016;13(8):683–9. PMCID: PMC4993324
    Reference Link
  • 1.
    Mahmoud A. New vaccines: challenges of discovery. Microb Biotechnol. 2016;9(5):549–52. PMCID: PMC4993171
    Reference Link
  • 1.
    Siu E, Ploss A. Modeling malaria in humanized mice: opportunities and challenges. Ann N Y Acad Sci. 2015;1342:29–36. PMID: 25678404
    Reference Link
  • 1.
    Ghersi D, Singh M. molBLOCKS: decomposing small molecule sets and uncovering enriched fragments. Bioinformatics. 2014;30(14):2081–3. PMCID: PMC4080744
    Reference Link
  • 1.
    Plotkin S, Mahmoud A, Farrar J. Establishing a Global Vaccine-Development Fund. N Engl J Med. 2015;373(4):297–300. PMID: 26200974
    Reference Link

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